Effect of Low Dose Atorvastatin Therapy on Baroreflex Sensitivity in Hypertensives

Celovska, Denisa; Kružliak, Peter; Rodrigo, Luı́s; Gonsorčík, J; Sabaka, Peter; Gáspár, Péter; Delev, Delian; Petrovič, Daniel; Dukát, Andrej; Gašpar, Ľudovít

doi:10.1007/s40292-016-0154-3

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In this present study, in Table 1, we showed baroreflex sensitivity has been decreased in hypertensive subjects, which was consistent with the established literature. [16–19] Blunt peripheral pressure sensors passivation and central cardiovascular regulatory dysfunction could be responsible for the attenuated baroreflex sensitivity. Stiffening and thickening of the aortic wall and of the carotid sinus wall is likely to reduce the baroreceptor afferent impulses, leading to decreasing the sensitivity of aortic and carotid baroreceptors.…”

Section: Discussionmentioning

confidence: 99%

Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension

Chang²,

Jia³

et al. 2018

Medicine

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This study is to investigate the effects of slow breathing on heart rate variability (HRV) and arterial baroreflex sensitivity in essential hypertension.We studied 60 patients with essential hypertension and 60 healthy controls. All subjects underwent controlled breathing at 8 and 16 breaths per minute. Electrocardiogram, respiratory, and blood pressure signals were recorded simultaneously. We studied effects of slow breathing on heart rate, blood pressure and respiratory peak, high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio of HRV with traditional and corrected spectral analysis. Besides, we tested whether slow breathing was capable of modifying baroreflex sensitivity in hypertensive subjects.Slow breathing, compared with 16 breaths per minute, decreased the heart rate and blood pressure (all P < .05), and shifted respiratory peak toward left (P < .05). Compared to 16 breaths/minute, traditional spectral analysis showed increased LF power and LF/HF ratio, decreased HF power of HRV at 8 breaths per minute (P < .05). As breathing rate decreased, corrected spectral analysis showed increased HF power, decreased LF power, LF/HF ratio of HRV (P < .05). Compared to controls, resting baroreflex sensitivity decreased in hypertensive subjects. Slow breathing increased baroreflex sensitivity in hypertensive subjects (from 59.48 ± 6.39 to 78.93 ± 5.04 ms/mm Hg, P < .05) and controls (from 88.49 ± 6.01 to 112.91 ± 7.29 ms/mm Hg, P < .05).Slow breathing can increase HF power and decrease LF power and LF/HF ratio in essential hypertension. Besides, slow breathing increased baroreflex sensitivity in hypertensive subjects. These demonstrate slow breathing is indeed capable of shifting sympatho-vagal balance toward vagal activities and increasing baroreflex sensitivity, suggesting a safe, therapeutic approach for essential hypertension.

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Section: Discussionmentioning

confidence: 99%

Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension

Chang²,

Jia³

et al. 2018

Medicine

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“…18) In nonobese patients with T2DM and dyslipidemia, low doses of atorvastatin improved BRS; 19) other studies also showed that statin increased BRS. 19,20) As a large percentage of patients with T2DM develop dyslipidemia, proper control of both blood glucose levels and lipid metabolism variables is important to prevent a reduction in BRS. Obesity, insulin resistance, hyperinsulinemia, and hypoadiponectinemia: BRS was reported to be decreased markedly in an obese group compared to a control group, indicating that obesity was a factor in sympathovagal imbalance (increased sympathetic nerve activity and decreased parasympathetic nerve activity).…”

Section: Clinical Features Of Reduced Baroreflex Sensitivitymentioning

confidence: 99%

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Sakamoto

Matsutani

Kayama³

2019

Int. Heart J.

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The evaluation of baroreflex sensitivity (BRS), which maintains systemic circulatory homeostasis, is an established tool to assess cardiovascular autonomic neuropathy in type 2 diabetes mellitus (T2DM). As BRS plays an important function in blood pressure regulation, reduced BRS leads to an increase in blood pressure variability, which further leads to reduced BRS. This sequence of events becomes a vicious cycle. The major risk factors for reduced BRS are T2DM and essential hypertension, but many other risk factors have been reported to influence BRS. In recent years, reports have indicated that glycemic variability (GV), such as short-and longterm GV that are considered important risk factors for macrovascular and microvascular complications, is involved in reductions in BRS independently of blood glucose levels. In this review, we discuss reduced BRS in T2DM, its features, and the potential for its reversal.(Int Heart J 2019; 60: 241-246)

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“…Hypercholesterolemia is a well-known risk factor for the development of atherosclerosis and atherosclerotic changes of the carotid arteries are associated with decreased BRS (Kwiterovich 2002;Nasr et al 2005). Improvement of BRS has also been observed in the statin-treated subjects (Patterson et al 2002;Celovska et al 2016). Additionally, despite role of repeated sympathetic activation in change of BRS and following chronic sympathetic overactivation was supposed (Cortelli et al 2012), this role still remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction

Šiarnik

Penesová

Rádiková

et al. 2021

Endocrine Regulations

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Objectives. Although multiple mechanisms, including autonomic dysfunction, seem to link sleep-disordered breathing (SDB) with dyslipidemia in animal studies, the data in clinical studies are limited. The aim of this study was to explore the association of lipoprotein levels with SDB measures in healthy habitual snorers. We supposed that autonomic dysfunction is the linking mechanism. Methods. We enrolled 110 previously healthy subjects with complaints of habitual snoring. To assess SDB, polysomnography was performed. Blood samples for the analysis of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were obtained in a fasting condition after the polysomnography. Baroreflex sensitivity (BRS) was used to assess the autonomic dysfunction. Results. In stepwise multiple linear regression analysis, minimal nocturnal blood oxygen saturation (beta=–0.240, p=0.020) and neck circumference (beta=0.224, p=0.03) were the only significant contributors in model predicting TG. SDB measures were not identified as significant contributors in models predicting TC, LDL, and HDL. We failed to find any significant difference in BRS in SDB subjects when compared according to the presence or absence of hypercholesterolemia/ hypertriglyceridemia. In SDB subjects, the area under the curve in a receiver operating curve to predict hypercholesterolemia and hypertriglyceridemia by BRS was 0.468 (95% CI: 0.328–0.608) and 0.425 (95% CI: 0.304–0.546), respectively. Conclusions. Our results suggest that minimal nocturnal blood oxygen saturation is significant contributor in model predicting TG. No significant decrease in BRS was found in SDB subjects with hypercholesterolemia and hypertriglyceridemia. In SDB subjects, the role of autonomic dys-function in the development of dyslipidemia remains controversial.

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Effect of Low Dose Atorvastatin Therapy on Baroreflex Sensitivity in Hypertensives

Abstract: An inverse correlation between blood pressure and BRS is present in hypertensives. BRS and BRSf is higher in low dose statin-treated patients with essential hypertension.

Cited by 5 publications

References 28 publications

Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension

Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction

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