Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients

Bailey, A R; Burchett, K

doi:10.1093/bja/78.1.97

Cited by 41 publications

(20 citation statements)

References 6 publications

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“…We observed no difference in the need for renal support therapy in our study between dopamine-treated patients and other patients. Fourth, dopamine administration can reduce the release of a number of hormones from the anterior pituitary gland, including prolactin (17,18), which can have important immunoprotective effects. The tendency toward a higher incidence of ICU-acquired infection in dopamine-treated patients in our study may favor this mechanism.…”

Section: Discussionmentioning

confidence: 99%

Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*

Sakr

Reinhart

Vincent

et al. 2006

Critical Care Medicine

351

203

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Section: Discussionmentioning

confidence: 99%

Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*

Sakr

Reinhart

Vincent

et al. 2006

Critical Care Medicine

351

203

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“…Recent studies have shown that dopamine may alter the inflammatory response in septic shock by decreasing the release of a number of hormones, including prolactin (41). Other potentially harmful endocrine effects have been demonstrated in trauma patients (42)(43)(44)(45).…”

Section: Rationalementioning

confidence: 99%

Vasopressor and inotropic support in septic shock: An evidence-based review

Beale

Hollenberg²,

Vincent³

et al. 2004

Critical Care Medicine

226

112

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An arterial catheter should be placed as soon as possible in patients with septic shock. Vasopressors are indicated to maintain mean arterial pressure of <65 mm Hg, both during and following adequate fluid resuscitation. Norepinephrine or dopamine are the vasopressors of choice in the treatment of septic shock. Norepinephrine may be combined with dobutamine when cardiac output is being measured. Epinephrine, phenylephrine, and vasopressin are not recommended as first-line agents in the treatment of septic shock. Vasopressin may be considered for salvage therapy. Low-dose dopamine is not recommended for the purpose of renal protection. Dobutamine is recommended as the agent of choice to increase cardiac output but should not be used for the purpose of increasing cardiac output above physiologic levels.

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“…Dopamine-induced PRL suppression was widely documented over the past 20 years in adults, children and neonates [32,80,202,208,[260][261][262][263]. As far as now, few evidences exist for preterm newborns, especially for VLBW infants, and only recently the eventual PRL suppression in this population assumed broadening relevance [80].…”

Section: B Dopamine Treatment and Prl Secretion In Neonates And Vlbwmentioning

confidence: 99%

Dopamine Administration in Very Low Birth Weight Preterm Infants:Emerging Issues on Endocrine Effects

Filippi¹,

Poggi²,

Pezzati

2007

CPR

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Preterm newborns weighing less than 1500 g (very low birth weight infants, VLBW) represent a critical population with high prevalence of morbidities, often requiring hemodynamic stabilization. Dopamine is a natural cathecolamine widely used for this purpose because it exerts pleiotropic anti-shock effects on cardiovascular, renal and endocrine systems, acting on adrenergic and dopaminergic receptors. Dopamine is a first choice drug in VLBW infants for inotropic support and optimisation of renal and splanchnic perfusion, mostly indicated for the treatment of hypotension, symptomatic patent ductus arteriosus and renal failure.Dopamine reversibly suppresses pituitary functions in adults but its effects on endocrine balance have been poorly studied in VLBW infants. Recent studies showed a dose-dependant reduction of TSH and T4 plasmatic levels in dopamine-treated VLBW infants and a positive correlation between dopamine infusion and incidence of transient hypothyroxinemia of prematurity.Further studies demonstrated that dopamine infusion also reduces PRL secretion in VLBW infants. TSH, T4 and PRL suppression rapidly reverses after dopamine withdrawal, when a significant hormonal rebound is observed. Therefore, such iatrogenic suppression probably cannot involve long-term injuries and T4 substitutive administration appears unecessary during short course dopamine treatment.Recent observations suggest that dopamine infusion can prevent early diagnosis of congenital hypothyroidism (CH) when screening programs are merely based on TSH plasmatic levels. Considering the severe neurodevelopmental outcome of undiagnosed CH, other screening strategies should be considered in treated neonates, such as simultaneous T4 and TSH testing and hormonal re-evaluation after dopamine discontinuation.A final issue of this review regards a possibile role of dobutamine as an alternative safer inotropic drug. PART 1. DOPAMINE AND DOBUTAMINE ADMINI-STRATION IN PRETERM INFANTS Clinical BackgroundPreterm infants weighing at birth less than 1500 g are referred to as very low birth weight (VLBW) infants and presently account for about 1-3 % of all neonates [1, 2]. However, they represent a widening subset of neonates with major vulnerability among the whole neonatal population. In fact, VLBW infants show a high incidence of morbitidies and systemic hypotension affects approximately one third of these infants [3]. Therefore, they often require early and careful hemodinamic stabilisation and, as a matter of fact, from 4% to 39% of VLBW infants receive inotropic support [3].Even if at present there are no clear evidences that the treatment of systemic hypotension is beneficial [4,5], such condition is widely and aggressively treated in VLBW infants in order to preserve a proper organ perfusion and an adequate cerebral blood flow [3,4,[6][7][8][9][10][11][12] since hypotension results associated with increased risk of intraventricular haemorrhage and unfavourable neurodevelopmental outcome [13][14][15][16]. Impaired cerebral autoregulation has been dem...

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Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients

Cited by 41 publications

References 6 publications

Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*

Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*

Vasopressor and inotropic support in septic shock: An evidence-based review

Dopamine Administration in Very Low Birth Weight Preterm Infants:Emerging Issues on Endocrine Effects

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