Effect of low-dose hydrocortisone on the expression of glucocorticoid receptor alpha of the septic kidney in rats and its protective effect on kidney injury

Wu, DW; Guo, HP

doi:10.1186/cc10763

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 130 Hydrocortisone can protect the kidneys and inhibit the activity of NF-κB by increasing the expression of GRα in the kidneys of rats with sepsis. 131 In addition, GR blockers were capable of restoring the renal antioxidant barrier by inhibiting the activities of adenosine deaminase and xanthine oxidase, implicating the involvements of GR in renal dysfunctions caused by combined oral contraceptive via disrupted glutathione antioxidative barrier.…”

Section: Glucocorticoid Receptor (Gr)mentioning

confidence: 99%

Nuclear receptors in renal health and disease

et al. 2022

View full text Add to dashboard Cite

Summary As a major social and economic burden for the healthcare system, kidney diseases contribute to the constant increase of worldwide deaths. A deeper understanding of the underlying mechanisms governing the etiology, development and progression of kidney diseases may help to identify potential therapeutic targets. As a superfamily of ligand-dependent transcription factors, nuclear receptors (NRs) are critical for the maintenance of normal renal function and their dysfunction is associated with a variety of kidney diseases. Increasing evidence suggests that ligands for NRs protect patients from renal ischemia/reperfusion (I/R) injury, drug-induced acute kidney injury (AKI), diabetic nephropathy (DN), renal fibrosis and kidney cancers. In the past decade, some breakthroughs have been made for the translation of NR ligands into clinical use. This review summarizes the current understanding of several important NRs in renal physiology and pathophysiology and discusses recent findings and applications of NR ligands in the management of kidney diseases.

show abstract

Section: Glucocorticoid Receptor (Gr)mentioning

confidence: 99%