Effect of low-dose lidocaine on MEPs in patients undergoing intracranial tumor resection with propofol anesthesia: A randomized controlled trial

Liu, Meijuan; Wang, Ning; Wang, Dong; Liu, Juan; Zhou, Xi‐Lang; Jin, Wenjie

doi:10.1097/md.0000000000029965

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…In an open-label, assessor-blinded RCT, 40 patients undergoing craniotomy for tumor resection were randomized to receive either lidocaine 1 mg/kg bolus followed by 1 mg/kg/h infusion or normal saline. 33 In addition, all patients received propofol, remifentanil, and cisatracurium infusions for the maintenance of anesthesia. The authors reported no statistically significant difference in TcMEP amplitudes or latencies at 35 min and 50 min post-induction of anesthesia between the 2 treatment groups.…”

Section: Lidocainementioning

confidence: 99%

“…The authors reported no statistically significant difference in TcMEP threshold voltages or in SSEP amplitudes by within-patient analysis. In an open-label, assessor-blinded RCT, 40 patients undergoing craniotomy for tumor resection were randomized to receive either lidocaine 1 mg/kg bolus followed by 1 mg/kg/h infusion or normal saline 33. In addition, all patients received propofol, remifentanil, and cisatracurium infusions for the maintenance of anesthesia.…”

Section: Current Evidencementioning

confidence: 99%

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Multimodal Analgesia and Intraoperative Neuromonitoring

Bebawy

Hemmer

2023

Journal of Neurosurgical Anesthesiology

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Intraoperative neuromonitoring has been a valuable tool for ensuring the functional integrity of vital neural structures by providing real-time feedback to the operative team during procedures where neurological structures are at risk. Commonly used intravenous and inhaled anesthetic drugs are known to affect waveform parameters measured with various intraoperative neuromonitoring modalities. While the concept of opioid-sparing multimodal analgesia has gained popularity in recent years, the impact of such a strategy on intraoperative neuromonitoring remains poorly characterized, in contrast to the more well-established concepts and literature regarding the effects of other hypnotic agents on neuromonitoring quality. The purpose of this focused review is to provide an overview of the clinical evidence pertaining to the pharmacological interaction of certain multimodal analgesics with routine intraoperative neuromonitoring modalities.

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Section: Lidocainementioning

confidence: 99%

Section: Current Evidencementioning

confidence: 99%

Multimodal Analgesia and Intraoperative Neuromonitoring

Bebawy

Hemmer

2023

Journal of Neurosurgical Anesthesiology

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Intraoperative somatosensory evoked potential (SEP) monitoring: an updated position statement by the American Society of Neurophysiological Monitoring

Toleikis,

Pace,

Jahangiri

et al. 2024

J Clin Monit Comput

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Somatosensory evoked potentials (SEPs) are used to assess the functional status of somatosensory pathways during surgical procedures and can help protect patients’ neurological integrity intraoperatively. This is a position statement on intraoperative SEP monitoring from the American Society of Neurophysiological Monitoring (ASNM) and updates prior ASNM position statements on SEPs from the years 2005 and 2010. This position statement is endorsed by ASNM and serves as an educational service to the neurophysiological community on the recommended use of SEPs as a neurophysiological monitoring tool. It presents the rationale for SEP utilization and its clinical applications. It also covers the relevant anatomy, technical methodology for setup and signal acquisition, signal interpretation, anesthesia and physiological considerations, and documentation and credentialing requirements to optimize SEP monitoring to aid in protecting the nervous system during surgery.

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Intravenous lidocaine infusion therapy and intraoperative neurophysiological monitoring in adolescents undergoing idiopathic scoliosis correction: A retrospective study

Bates,

Cave,

West

et al. 2024

Pediatric Anesthesia

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BackgroundPosterior spinal instrumentation and fusion is an established surgical procedure for the correction of adolescent idiopathic scoliosis. Intraoperative neurophysiological monitoring is standard practice for this procedure. Anesthetic agents can have different, but significant, effects on neurophysiological monitoring outcomes.AimTo determine if intravenous lidocaine infusion therapy has an impact on the intraoperative neurophysiological monitoring during posterior spinal instrumentation and fusion for adolescent idiopathic scoliosis.MethodsFollowing ethical approval, we conducted a retrospective review of charts and the archived intraoperative neurophysiological data of adolescents undergoing posterior spinal instrumentation and fusion for adolescent idiopathic scoliosis. Intraoperative neurophysiological monitoring data included the amplitude of motor evoked potentials and the amplitude and latency of somatosensory evoked potentials. A cohort who received intraoperative lidocaine infusion were compared to those who did not.ResultsEighty‐one patients were included in this analysis, who had surgery between February 4, 2016 and April 22, 2021: 39 had intraoperative intravenous lidocaine infusion and 42 did not. Based on hourly snapshot data, there was no evidence that lidocaine infusion had a detrimental effect on the measured change from baseline for MEP amplitudes in either lower (mean difference 41.9; 95% confidence interval −304.5 to 388.3; p = .182) or upper limbs (MD −279.0; 95% CI −562.5 to 4.4; p = .054). There was also no evidence of any effect on the measured change from baseline for SSEP amplitudes in either lower (MD 16.4; 95% CI −17.7 to 50.5; p = .345) or upper limbs (MD −2.4; 95% CI −14.5 to 9.8; p = .701). Finally, there was no evidence of a difference in time to first reportable neurophysiological event (hazard ratio 1.13; 95% CI 0.61 to 2.09; p = .680).ConclusionsData from these two cohorts provide preliminary evidence that intravenous lidocaine infusion has no negative impact on intraoperative neurophysiological monitoring during PSIF for adolescent idiopathic scoliosis.

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Effect of low-dose lidocaine on MEPs in patients undergoing intracranial tumor resection with propofol anesthesia: A randomized controlled trial

Cited by 3 publications

References 14 publications

Multimodal Analgesia and Intraoperative Neuromonitoring

Multimodal Analgesia and Intraoperative Neuromonitoring

Intraoperative somatosensory evoked potential (SEP) monitoring: an updated position statement by the American Society of Neurophysiological Monitoring

Intravenous lidocaine infusion therapy and intraoperative neurophysiological monitoring in adolescents undergoing idiopathic scoliosis correction: A retrospective study

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