Effect of Low-Dose Prednisone on Leukocyte Counts and Subpopulations in Patients With Rheumatoid Arthritis

Serra-Bonett, Natali; snih, Soham Al Snih al; Rodríguez, M.

doi:10.1097/rhu.0b013e3181a3ac2d

Cited by 10 publications

(6 citation statements)

References 5 publications

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“…The observed decreases in TNF-a release were dose-dependent. In addition, acute, dose-dependent changes in peripheral WBC count were observed following single and multiple doses of all prednisone doses studied, as shown previously (24,25,26). It is interesting to note that for both LPSstimulated TNF-a release and peripheral WBC count, prednisone-induced effects were near-complete within hours after a single dose, and subsequent doses did not result in additional changes in these biomarkers.…”

Section: Discussionsupporting

confidence: 81%

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals

Kauh

Mixson

Malice

et al. 2012

European Journal of Endocrinology

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Objective: Use of glucocorticoids for anti-inflammatory efficacy is limited by their side effects. This study examined, in the same individuals, prednisone's acute, dose-dependent effects on inflammation as well as biomarkers of glucose regulation and bone homeostasis. Design: In this randomized, double-blind, parallel-design trial of healthy adults demonstrating cutaneous allergen-induced hypersensitivity, patients received placebo or prednisone 10, 25 or 60 mg daily for 7 days. Methods: Effects on peripheral white blood cell (WBC) count, ex vivo whole blood lipopolysaccharide (LPS)-stimulated TNF-a release and response to cutaneous allergen challenge were assessed concurrently with biomarkers for glucose tolerance and bone turnover. Results: Differential peripheral WBC counts changed significantly within hours of prednisone administration. Ex vivo, LPS-stimulated TNF-a was significantly reduced by all prednisone doses on days 1 and 7. The late phase cutaneous allergen reaction was significantly reduced with prednisone 60 mg vs placebo on days 1 and 7. Oral glucose tolerance tests revealed significant increases in glycaemic excursion on days 1 and 7, whereas increases in insulin and C-peptide excursions were more notable on day 7 with all doses of prednisone. The bone formation markers osteocalcin, and procollagen I N-and C-terminal peptides decreased significantly on days 1 and 7 vs placebo. Conclusions: In healthy young adults after single doses as low as 10 mg, prednisone treatment has significant effects on glucose tolerance and bone formation markers within hours of treatment, in parallel with anti-inflammatory effects.

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Section: Discussionsupporting

confidence: 81%

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals

Kauh

Mixson

Malice

et al. 2012

European Journal of Endocrinology

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“…The AST elevation was likely from a skeletal muscle source [16]. The elevated white blood cells (WBCs) count may have been related to prednisone use [17].…”

Section: Discussionmentioning

confidence: 99%

Possible exercised-induced rhabdomyolysis associated with terbinafine

Bui

Gafni-Pappas

2019

Oxford Medical Case Reports

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Introduction. Terbinafine is reported to be associated with rhabdomyolysis. We present a patient taking terbinafine who may have developed exercise-induced rhabdomyolysis. Case Report. A healthy 40-year-old female developed onychomycosis of the right first toe for which she was taking terbinafine. After an increase in her exercise regimen, she began experiencing notable myalgias of the triceps. During outpatient evaluation, the patient was found to have elevated and worsening creatine kinase (CK) and aspartate transaminase. At evaluation in the emergency department, CK was <5000 IU/L and had decreased. She did not have electrolyte abnormalities, kidney injury or kidney failure. Discussion. Patients may be at risk for exercise-induced rhabdomyolysis while on terbinafine and may need to be cautioned regarding the intensity of exercise.

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“…In this case elevated liver enzymes and be explained as Flavipiravir and COVID 19 both can cause increase in liver enzymes 6 so this drug should be used with caution in patients with hepatic impairment. Oral thrush ,hyperglycemia ,leukocytosis in later part of the disease can be explained as administration of methylprednisolone 5 and hyperglycemia can complicate the disease process for that insulin or inulin analogue can be used for a fair to good glycemic control, local anti fungal can be used to minimize hepatic metabolism in hepatic enzyme impaired patients. Director General Health Services(DGHS),govt of Bangladesh data shows there is a tendency to be non-hospitalization in case of COVID 19 patients though number of prepared support team is fare quantitatively and qualitatively 1 .…”

Section: Discussionmentioning

confidence: 99%

A case report of COVID-19 with multiple comorbidities with a positive outcome in early days of COVID-19 outbreak in Bangladesh

Mohammed

Tasmin

et al. 2020

Birdem Med J

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We present a case of 68-year-old man with diabetes, heart failure, status post-coronary artery bypass grafs, cardiac resynchronization therapy defibrillator in situ, altered liver function, with corona virus disease 2019. He presented with cough and high grade fever with occasional dyspnea. He was treated at home with favipiravir, methyl prednisolone, enoxaparin and antibiotics and home oxygen therapy. He re-tested positive on 14th and 21st day and later on 31st day he was found RT-PCR negative for SARS-CoV-2. Patient came for a follow-up after 3 months in healthy state with normal D-dimer and other inflammatory markers. Birdem Med J 2020; 10, COVID Supplement: 131-134

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Effect of Low-Dose Prednisone on Leukocyte Counts and Subpopulations in Patients With Rheumatoid Arthritis

Cited by 10 publications

References 5 publications

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals

Possible exercised-induced rhabdomyolysis associated with terbinafine

A case report of COVID-19 with multiple comorbidities with a positive outcome in early days of COVID-19 outbreak in Bangladesh

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