Effect of Low Doses of Alcohol on the Warm-Up Phenomenon in Patients With Stable Angina Pectoris

Marinaccio, Leonardo; Lanza, Gaetano Antonio; Niccoli, Giampaolo; Fabretti, Alessandro; Lamendola, Priscilla; Barone, Lucy; Monaco, Antonio Di; Clemente, Francesca Di; Crea, Filippo

doi:10.1016/j.amjcard.2008.03.025

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…Maximal ST segment depression during sequential stress tests. Seventeen studies assessed maximal STD for the FWOP 1,11,12,14,18,19,21,22,25,29,[33][34][35][36][37][38][39] (Table 1). The difference between the first and second stress test for maximal STP was À0.38 mm (95% CI: À0.66 to À0.10), p < 0.01 (Figure 2(b)) and the test for heterogeneity was nonsignificant, Q (df ¼ 21) ¼ 3.2, p ¼ 1.000.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…Rate pressure-product at 1 millimeter ST depression during sequential stress tests. Eighteen studies were included in the FWOP analysis regarding RPP at 1 mm STD 1,4,13,14,16,17,[19][20][21]23,[25][26][27][28][29][30]34,36 (Table 1). The difference between the first and the second stress test regarding the RPP at 1 mm STD was 1.80 Â 10 3 mm Hg (HR Â SBP) (95% CI: 1.20-2.41), p < 0.001 (Figure 3(a)) and the test for heterogeneity was nonsignificant, Q (df ¼ 23) ¼ 12.21, p ¼ 0.967.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…Peak rate pressure-product. Seventeen studies were included in the FWOP analysis 1,4,11,12,14,20,21,24,[26][27][28][29][33][34][35]39,41 (Table 1). The difference between the first and the second stress test for peak RPP was 1.65 Â 10 3 mm Hg (95% CI: 0.93-2.38), p < 0.001 and the test for heterogeneity was non-significant, Q (df ¼ 18) ¼ 5.03, p ¼ 0.999.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…31,32 Total exercise stress test time. Fifteen studies recorded total FWOP exercise time 1,[11][12][13][14][15]20,[22][23][24]26,27,[33][34][35] (Table 1). The difference between the first and the second stress test for the total exercise time was 50 s (95% CI: 36-64), p < 0.001 (Figure 3(b)).…”

Section: Results Of Meta-analysismentioning

confidence: 99%

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Exercise-induced ischemic preconditioning detected by sequential exercise stress tests: A meta-analysis

Lalonde

Poirier

Sylvestre

et al. 2013

Eur J Prev Cardiolog

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Exercise-induced ischemic preconditioning (IPC) can be assessed with the second exercise stress test during sequential testing. Exercise-induced IPC is defined as the time to 1 mm ST segment depression (STD), the rate-pressure product (RPP) at 1 mm STD, the maximal ST depression and the rate-pressure product at peak exercise. The purpose of this meta-analysis is to validate the parameters used to assess exercise-induced IPC in the scientific community. A literature search was performed using electronic database. The main key words were limited to human studies, which were (a) ischemic preconditioning, (b) warm-up phenomenon, and (c) exercise. Meta-analyses were performed on the study-specific mean difference between the clinical measures obtained in the two consecutive stress tests (second minus first test score). Random effect models were fitted with inverse variance weighting to provide greater weight to studies with larger sample size and more precise estimates. The search resulted in 309 articles of which 34 were included after revision (1053 patients). Results are: (a) time to 1 mm ST segment depression increased by 91 s (95% confidence interval (CI): 75-108), p < 0.001; (b) peak ST depression decreased by -0.38 mm (95% CI: -0.66 to -0.10), p < 0.01; and (c) rate-pressure product at 1 mm STD increased by 1.80 × 10(3)mmHg (95% CI: 1.0-2.0), p < 0.001. This is the first meta-analysis to set clinical parameters to assess the benefit of exercise-induced ischemic preconditioning in sequential stress testing. The results of this first meta-analysis on the sequential stress test confirm what is presented in the literature by independent studies on exercise-induced ischemic preconditioning. From now on, the results could be used in further research to set standardized parameters to assess the phenomenon.

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Section: Results Of Meta-analysismentioning

confidence: 99%

Section: Results Of Meta-analysismentioning

confidence: 99%

Section: Results Of Meta-analysismentioning

confidence: 99%

Section: Results Of Meta-analysismentioning

confidence: 99%

See 2 more Smart Citations

Exercise-induced ischemic preconditioning detected by sequential exercise stress tests: A meta-analysis

Lalonde

Poirier

Sylvestre

et al. 2013

Eur J Prev Cardiolog

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“…Acute RW consumption, in comparison with gin, had a greater downregulatory effect on genes related to atherosclerosis progression in men with high CVD risk, probably due to the higher phenolic content [96]. In patients with stable angina pectoris, the acute intake of low doses of RW did not significantly affect ischemic pre-conditioning (IPC) during exercise stress testing [57]. Acute RW and DRW consumption did not improve coronary epicardial diameters or flow rate, even though both beverages reduced vasoconstrictive peptide endothelin-1 levels [64].…”

Section: Cardiovascular Functionmentioning

confidence: 94%

Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate

Lombardo¹,

Feraco

Camajani

et al. 2023

Nutrients

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A strong controversy persists regarding the effect of red wine (RW) consumption and health. Guidelines for the prevention of cardiovascular diseases (CVD) and cancers discourage alcohol consumption in any form, but several studies have demonstrated that low RW intake may have positive effects on CVD risk. This review evaluated randomised controlled trials (RCTs), examining the recent literature on the correlations between acute and chronic RW consumption and health. All RCTs published in English on PubMed from 1 January 2000 to 28 February 2023 were evaluated. Ninety-one RCTs were included in this review, seven of which had a duration of more than six months. We assessed the effect of RW on: (1) antioxidant status, (2) cardiovascular function, (3) coagulation pathway and platelet function, (4) endothelial function and arterial stiffness, (5) hypertension, (6) immune function and inflammation status, (7) lipid profile and homocysteine levels, (8) body composition, type 2 diabetes and glucose metabolism, and (9) gut microbiota and the gastrointestinal tract. RW consumption mostly results in improvements in antioxidant status, thrombosis and inflammation markers, lipid profile, and gut microbiota, with conflicting results on hypertension and cardiac function. Notably, beneficial effects were observed on oxidative stress, inflammation, and nephropathy markers, with a modest decrease in CVD risk in five out of seven studies that evaluated the effect of RW consumption. These studies were conducted mainly in patients with type 2 diabetes mellitus, and had a duration between six months and two years. Additional long-term RCTs are needed to confirm these benefits, and assess the potential risks associated with RW consumption.

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Exercise-Induced Ischemic Preconditioning and the Potential Application to Cardiac Rehabilitation

Lalonde

Poirier

Arvisais

et al. 2015

Journal of Cardiopulmonary Rehabilitation and Prevention

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Exercise-induced ischemic preconditioning (IPC) can be assessed by the results of the second of sequential exercise tests. Exercise-induced IPC is quantified by using the time to 1-mm ST-segment depression, the rate-pressure product at 1-mm ST-segment depression, the maximal ST-segment depression, and the rate-pressure product at the peak of exercise. Few studies reported whether exercise-induced IPC could be used in cardiovascular rehabilitation. A systematic review of the literature limited to human studies was performed using electronic databases, and the main key words were ischemic preconditioning, warm-up phenomenon, and exercise. After careful review, 38 articles were included in the systematic review. This review summarizes the molecular pathways of IPC and describes the first window of protection induced by sequential exercise tests, as well as the effect of medication on exercise-induced IPC. A section on the exercise protocol, mode of exercise, and intensity provides understanding as to what is needed for clinicians to induce IPC with sequential stress tests. The final section of the review is a discussion of the potential use of exercise-induced IPC in a cardiovascular rehabilitation setting. Even if exercise-induced IPC is a well-documented phenomenon, additional studies are needed in order to more fully understand its use in rehabilitation.

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Effect of Low Doses of Alcohol on the Warm-Up Phenomenon in Patients With Stable Angina Pectoris

Cited by 4 publications

References 13 publications

Exercise-induced ischemic preconditioning detected by sequential exercise stress tests: A meta-analysis

Exercise-induced ischemic preconditioning detected by sequential exercise stress tests: A meta-analysis

Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate

Exercise-Induced Ischemic Preconditioning and the Potential Application to Cardiac Rehabilitation

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