Effect of Low Fluence Diode Laser Irradiation on the Hydraulic Conductivity of Perfused Trabecular Meshwork Endothelial Cell Monolayers

Roberts, Cynthia J.; Rivera, Brian K.; Grzybowski, Deborah M.; Mahmoud, Ashraf M.; Weber, Paul A.

doi:10.1080/02713680701486394

Cited by 5 publications

(3 citation statements)

References 60 publications

(69 reference statements)

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“…After 10 min, the outflow of the aqueous humor increases sharply. 18 LLLT seems to inhibit the sympathetic nervous system, while the parasympathetic nervous system is stimulated. In addition, the macrophages activated by laser irradiation phagocytose the cellular debris, and the aqueous humor drainage pathways are cleared and kept free.…”

Section: Discussionmentioning

confidence: 94%

Methods, Therapeutic Applications, and Effects of Low-Level Laser Therapy in Ophthalmology

Ivandić

2024

Nat Cell Sci

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Despite considerable progress in ophthalmological therapy, a few ocular diseases without satisfying therapeutic options remain, often leading to progressive and irreversible loss of vision. A noninvasive, yet simple novel therapeutic approach is low-level laser therapy (LLLT). In this review, its method, therapeutic applications, and effects are described. Ocular tissues are irradiated for 30 s by applying a dose of 300 mW/cm 2 using a low-power, non-focused diode laser with a peak power of 10 mW at a wavelength of 780 nm and a frequency of 292 Hz. Treatments are given daily during the acute phase and further continued once or twice a week to treat chronic disease conditions. The applied dose is very low; there are no thermal effects and no pain, nor adverse events. Therefore, LLLT can be used for children and repeated as necessary. This therapy has resulted in positive results for the treatment of amblyopia, glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, and uveitis. LLLT enhances physiological processes. It can be considered a stimulus of regeneration and a regulator at the cellular level. LLLT is an effective therapeutic approach to maintain vision, to revitalize tissue, and to recover lost physiological cell functions. This treatment is simple, without side effects, and may even reduce therapeutic and social costs and burden of disease. LLLT should be investigated further to confirm its promising results.

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Section: Discussionmentioning

confidence: 94%

Methods, Therapeutic Applications, and Effects of Low-Level Laser Therapy in Ophthalmology

Ivandić

2024

Nat Cell Sci

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“…Previous experimental work suggests that the trabecular meshwork and the endothelial cell lining of the inner wall of Schlemm's canal are the primary sites of outflow resistance. [25][26][27] Bypassing this resistance through laser-created channels in the trabecular meshwork may be a viable procedure for increasing outflow and lowering intraocular pressure. Other potential clinical applications include transection and removal of fibrocellular and fibrovascular membranes and dissection of the vascular sheath at arteriole/venule crossing points in various vitreoretinal diseases.…”

Section: Discussionmentioning

confidence: 99%

Ablation of Intraocular Tissue with Fiber-optic Probe–Delivered 266-nm and 213-nm Laser Energy

Miller

Yu³

et al. 2009

Invest. Ophthalmol. Vis. Sci.

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“…Trabeculectomy, the most widely used incisional glaucoma surgery, can lower IOP more effectively, but is associated with a higher risk of severe complications and substantial long term failure 6,9,10. Laser Trabeculoplasty (LT), though widely utilized using various laser sources, has modest success rates that diminish over time 10–13. As a result of these therapeutic limitations, there continues to be demand for improved glaucoma treatments.…”

Section: Introductionmentioning

confidence: 99%

In vivo femtosecond laser subsurface scleral treatment in rabbit eyes

et al. 2010

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Background and Objectives-The progression of glaucoma can be reduced or delayed by reducing intraocular pressure (IOP). The properties of femtosecond laser surgery, such as markedly reduced collateral tissue damage, coupled with the ability to achieve isolated subsurface surgical effects in the sclera, make this technology a promising candidate in glaucoma management. In this pilot study we demonstrate the in vivo creation of partial thickness subsurface drainage channels with the femtosecond laser in the sclera of rabbit eyes in order to increase aqueous humor (AH) outflow.

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Effect of Low Fluence Diode Laser Irradiation on the Hydraulic Conductivity of Perfused Trabecular Meshwork Endothelial Cell Monolayers

Abstract: Low-fluence diode laser irradiation increases hydraulic conductivity in viable perfused TM cell monolayers when compared to baseline values or simultaneous nonirradiated controls while decreasing hydraulic conductivity in nonviable monolayers.

Cited by 5 publications

References 60 publications

Methods, Therapeutic Applications, and Effects of Low-Level Laser Therapy in Ophthalmology

Methods, Therapeutic Applications, and Effects of Low-Level Laser Therapy in Ophthalmology

Ablation of Intraocular Tissue with Fiber-optic Probe–Delivered 266-nm and 213-nm Laser Energy

In vivo femtosecond laser subsurface scleral treatment in rabbit eyes

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