Effect of Low Frequency Noise on Fundic Mucosa of Adult Male Albino Rats and the Role of Vitamin E Supplementation (Histological and Immunohistochemical Study)

Ahmed, Sabah M.; Abdelrahman, Shaimaa A; Hassan, Ebtehal Z.

doi:10.4172/2161-0681.1000256

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Earlier noise animal studies reported fibrous thickening of gastric lesions and media, massive collagen deposition, rupture of the inner elastic lamina ( 4 ), massive death of epithelial cells and cell degeneration without inflammation ( 40 ), cell shedding, pyknotic nuclei and separated basal lamina in mucosal cells, thickened mucosa, mononuclear cell infiltrates, vacuolated cytoplasm in parietal cells, and increased percentage of collagen fibres in fundic mucosa ( 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…We know today that noise can affect health beyond loss of hearing ( 1 ). Exposure to noise can disturb physiological processes and affect systems such as cardiovascular ( 2 ), digestive ( 3 , 4 ), immune ( 5 , 6 , 7 ), endocrine ( 8 ), and nervous ( 9 ). We also know that toluene – used as solvent in many products and industries ( 10 , 11 , 12 , 13 , 14 ), including vehicle fuel ( 15 ) – can at high concentrations cause nervous system disorders ( 16 , 17 ), cardiovascular changes ( 18 ), and respiratory problems ( 19 ).…”

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confidence: 99%

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Toxicopathological changes induced by combined exposure to noise and toluene in New Zealand White rabbits

Abouee-Mehrizi

Rasoulzadeh

Kazemi

et al. 2022

Archives of Industrial Hygiene and Toxicology

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Noise and toluene can have significant adverse effects on different systems in the human body, but little is known about their combination. The aim of this study was to see how their combined action reflects on serum levels of inflammatory cytokines tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), body weight, and pathological changes in the heart, lung, stomach, and spleen tissues. To do that we exposed New Zealand rabbits to 1000 mg/L toluene and 100 dB of white noise in a chamber specifically designed for the purpose over two consecutive weeks. Serum levels of TNF-α and IL-1β were measured with the enzyme-linked immunosorbent assay (ELISA), whereas Bax and Bcl-2 expressions in tissues were determined with real-time polymerase chain reaction (PCR). Noise and toluene changed TNF-α and IL-1β serum levels on different days following the end of exposure and significantly increased the Bax/Bcl-2 ratio in the lung and spleen. In addition, they induced different pathological changes in the heart, lung, spleen, and stomach tissues. This study has confirmed that exposure to noise and toluene can induce a range of toxicopathological changes, probably by inducing inflammatory pathways and apoptosis, but their combined effects look weaker than those of its components, although histopathological findings suggest the opposite.

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Section: Resultsmentioning

confidence: 99%