Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test

Ghafouri, Samireh; Fathollahi, Yaghoub; Javan, Mohammad; Shojaei, Amir; Asgari, Ali; Mirnajafi‐Zadeh, Javad

doi:10.1016/j.eplepsyres.2016.06.010

Cited by 67 publications

(41 citation statements)

References 70 publications

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“…However, further work would have to be carried out to determine to what extent, if any, alternations and repetitions are implicated in short term memory in the Y-maze. Here, we confirmed that both alternations and repetitions remain as a highly reliable behavioral pattern that is conserved across species (Ghafouri et al 2016; Lewis et al 2017; Pickering et al 2015).…”

Section: Discussionsupporting

confidence: 79%

“…Interestingly, decreases in pure alternations and increases in pure repetition behavior in lateralized animals was first described by Rodriguez et al (1992), who demonstrated that both stress and over-training decrease the alternation/repetition ratio through the promotion of an increase of biased responses. Overall, we confirmed that both alternations and repetitions remain as a highly reliable behavioral pattern that is conserved across species (Ghafouri et al 2016; Lewis et al 2017; Pickering et al 2015).…”

Section: Discussionsupporting

confidence: 78%

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Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

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6Once considered a uniquely human attribute, behavioral laterality has proven to be 3 7 ubiquitous among non human animals, being frequently associated with different 3 8 neurophenotypes in rodents and fish species. Zebrafish (Danio rerio) are a versatile vertebrate 3 9 model system that has been widely used in translational neuropsychiatric research due their 4 0 highly conserved genetic homology, well characterized physiological and extensive behavioral 4 1 repertoire. Although the spontaneous left-and right-bias responses and associated behavioral 4 2 domains (e.g. stress reactivity, aggression and learning) have previously been observed in other 4 3 teleost species, no information regarding how spontaneous motor left-right bias responses of 4 4 zebrafish predicts other behavioral domains has been described. Thus, we aimed to investigate 4 5 the existence and incidence of natural left-right bias of adult zebrafish in the Y-maze test and 4 6 explore any relationship of biasedness on the performance of different behavioral domains. This 4 7 included learning about threat-cues in the fear conditioning test and locomotion and anxiety-4 8related behavior in the novel tank diving test. In conclusion, we showed for the first time that 4 9 handling in a single day (see Fig. 1). During the pair-housing period, animals had shared

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 78%

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

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“…In this task, over the course of multiple arm entries, animals have a natural tendency to enter the recently visited arm less frequently, thus increasing the number of alternations across the test (Drew, Miller, & Baugh, 1973; Hughes, 2004; Kokkinidis & Anisman, 1976; Swonger & Rech, 1972). In general, various configurations of the Y-maze task have been used to study learning and processes in animal models, including rodents (Fu et al, 2017; Ghafouri et al, 2016; Luine, 2015) and fish (Aoki, Tsuboi, & Okamoto, 2015; Cleal & Parker, 2018; Cognato Gde et al, 2012). Both decreased alternations and increased repetitions are affected pharmacologically by muscarinic and NMDA-receptor antagonists, and additionally by β-amyloid peptides in rodents (Cunha et al, 2008; Hiramatsu & Inoue, 2000; Park et al, 2010; Walker & Gold, 1992).…”

Section: Discussionmentioning

confidence: 99%

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Fontana

Gibbon

Sudwarts

et al. 2020

Preprint

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5Early-life stress (ELS) is defined as a short or chronic period of trauma, environmental or 3 6 social deprivation, which can affect different neurochemical and behavioral patterns during 3 7 adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human 3 8 neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating 3 9systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young 4 0 animals (six weeks post-fertilization), for three consecutive days, to three stressors, and analyzing 4 1 the impact of this on adult zebrafish behavior (sixteen weeks post-fertilization). The ELS impact in 4 2 adults was assessed though analysis of performance on tests of unconditioned memory (free 4 3 movement pattern Y-maze test), exploratory and anxiety-related task (novel tank diving test) and 4 4 social cohesion (shoaling test). Here, we show for the first time that moderate ELS increases the 4 5 number of pure alternations compared to pure repetitions in the unconditioned Y-maze task, 4 6suggesting increased spatial short-term memory, but has no effect on shoal cohesion, locomotor 4 7 profile or anxiety-like behavior. Overall, our data suggest that moderate ELS may be linked to 4 8 adaptive flexibility which contributes to build 'resilience' in adult zebrafish by improving short-4 9 term spatial memory performance. 5 0 5 1

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“…Another research with nine patients with intractable epilepsy underwent by bilateral ANT-DBS suggested significant improvements in both verbal recall fluency tasks and oral information processing [30]. Application of LFS in kindling-induced seizure animal models improved cognitive impairment associated spontaneous alternation behavior in Y-maze test, concerning of the upregulation in calcineurin gene expression in the hippocampal area [96]. Further, application of LFS in kindle rats for a long-term could improve effect on spatial learning and memory, which show a dependence of the number of applied LFS [97].…”

Section: Mechanism Of Dbs For Epilepsy and Associated Comorbiditiesmentioning

confidence: 96%

Mechanisms of Deep Brain Stimulation for Epilepsy and Associated Comorbidities

Deng¹,

Luan²

2017

Neuropsychiatry

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Deep brain stimulation (DBS) is an important effective treatment for pharmacoresistant epilepsy, but its mechanism is still not clear. In clinical application, the possible effects and mechanisms DBS in treatment of epilepsy are different according to different stimulation parameters. We reviewed the mechanisms of DBS in different frequencies including high frequency and low frequency in the treatment of epilepsy, covering the inhibition or excitation of synaptic, pathological neuronal and network activity, pathological rhythms or oscillation and neurotransmitter systems. As the onset and progression of seizure, it's more frequent accompanied with cognitive and psychiatric comorbidities in patients with epilepsy. We review the possible mechanism of DBS in treating epilepsy associated comorbidities including cognitive and memory disorders. With the further development of clinical application and basic research of DBS, the processing of clinical individualized therapy of DBS in epilepsy and evaluation of effects of DBS in associated comorbidities may contribute to extend the understanding of the mechanisms of DBS for epilepsy and associated comorbidities.

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Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test

Cited by 67 publications

References 70 publications

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Mechanisms of Deep Brain Stimulation for Epilepsy and Associated Comorbidities

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