Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy – A pilot study

Anju, M.; Chacko, Lincy; Chettupalli, Yenoshan; Maiya, Arun G; Velladath, Saleena Ummer

doi:10.1016/j.dsx.2019.01.022

Cited by 22 publications

(17 citation statements)

References 28 publications

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“…We have also shown that treatment with high‐dose vitamin D results in a significant reduction in neuropathic symptoms 23 and improves the quality of life 24 in patients with painful diabetic neuropathy. More recently, a study using low‐level laser therapy in people with painful diabetic neuropathy raised 25(OH)D levels and there were improvements in neuropathic pain and quality of life 49 …”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency is associated with painful diabetic neuropathy

Alam

Petropoulos

Ponirakis

et al. 2020

Diabetes Metabolism Res

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BackgroundThe aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy.MethodsForty‐three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non‐diabetic healthy control subjects (C) underwent assessment of neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy, corneal confocal microscopy (CCM) and measurement of serum 25(OH)D.ResultsThere were no significant differences for age, BMI, HbA1c, lipids, neurological deficits, QST, electrophysiology, intra‐epidermal nerve fibre density (IENFD) and corneal nerve morphology between patients with DPN and PDN. Both positive (hyperalgesia and allodynia) and negative symptoms (paraesthesia and numbness) of diabetic neuropathy were greater in PDN compared with DPN (P = .009 and P = .02, respectively). Serum 25(OH)D levels were significantly lower in PDN (24.0 ± 14.1 ng/mL) compared with DPN (34.6 ± 15.0 ng/mL, P = .01) and controls (34.1 ± 8.6 ng/mL, P = .03). The odds ratio in favour of painful diabetic neuropathy was 9.8 [P = .003 (95% CI, 2.2–76.4)] for vitamin D deficiency (<20 ng/mL) and 4.4 [P = .03 (95% CI, 1.1‐19.8)] for vitamin D insufficiency (<30 ng/mL).ConclusionsThis study suggests that vitamin D deficiency and insufficiency are associated with painful diabetic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency is associated with painful diabetic neuropathy

Alam

Petropoulos

Ponirakis

et al. 2020

Diabetes Metabolism Res

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“…When nanoparticles including magnesium were administered to the experimental diabetic neuropathy rat model, the morphological abnormalities of dorsal root ganglion neurons and motor dysfunction improved [ 77 , 78 ]. In addition, low-level laser therapy resulted in good prognoses in diabetic peripheral neuropathy by increasing serum magnesium levels [ 79 ].…”

Section: Other Acute and Chronic Painmentioning

confidence: 99%

Magnesium and Pain

Shin

Hwan

2020

Nutrients

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In terms of antinociceptive action, the main mode of action of magnesium involves its antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central sensitization and attenuates preexisting pain hypersensitivity. Given the pivotal function of NMDA receptors in pain transduction, magnesium has been investigated in a variety of pain conditions. The oral and parenteral administration of magnesium via the intravenous, intrathecal, or epidural route may alleviate pain and perioperative anesthetic and analgesic requirements. These beneficial effects of magnesium therapy have also been reported in patients with neuropathic pain, such as malignancy-related neurologic symptoms, diabetic neuropathy, postherpetic neuralgia, and chemotherapy-induced peripheral neuropathy. In addition, magnesium treatment is reportedly able to alleviate fibromyalgia, dysmenorrhea, headaches, and acute migraine attacks. Although magnesium plays an evolving role in pain management, better understanding of the mechanism underlying its antinociceptive action and additional clinical studies is required to clarify its role as an adjuvant analgesic.

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“…Previous studies have described the different types of mechanical peripheral nerve injury and evaluations of neuropathic pain in human and animal models using the stimuli that give the degree of mechanical, chemical, and temperature-induced changes [ 17 , 25 , 26 ]. In the present study, we evaluated the neuropathic changes by 5.07 Monofilament (10 g) test, Hind paw withdrawal test for hot and cold stimulus where the neuropathy induced leg showed the delayed response.…”

Section: Discussionmentioning

confidence: 99%

“…Bertolini et al treated the animals’ sciatic nerve with low-level laser therapy (LLLT) of dosage 4, 6 J/cm 2, and 830 nm wavelength and found a significant change in paw-withdrawal time on the fifth day of therapy [ 30 ]. Anju et al suggest that low-level laser therapy of dosage 3.1 J/cm 2 significantly improved in painful diabetic neuropathy conditions [ 17 ]. PBMT can enhance the microcirculation of nerves, thereby improving the blood supply.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Photobiomodulation Therapy on Oxidative Stress Markers in Healing Dynamics of Diabetic Neuropathic Wounds in Wistar Rats

Karkada

Maiya

Arany

et al. 2021

Cell Biochem Biophys

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Background Prolonged and overlapping phases of wound healing in diabetes are mainly due to the redox imbalance resulting in the chronicity of the wound. Photobiomodulation therapy works on the principle of absorption of photon energy and its transduction into a biological response in the living tissue. It alleviates the cellular responses, thereby improving the mechanism of wound healing in diabetes. Objective To find out the effect of photobiomodulation therapy of dosage 4 J/cm2 in the healing dynamics of diabetic neuropathic wounds in Wistar rats and its relation with oxidative stress markers. Methodology Diabetes was induced using Streptozotocin of 60 mg/kg of body weight to eighteen female Wistar rats. Neuropathy was induced by the sciatic nerve crush injury followed by an excisional wound of 2 cm2 on the back of the animal. Experimental group animals were treated with dosage 4 J/cm2 of wavelength 655 and 808 nm, and control group animals were kept unirradiated. The biomechanical, histopathological, and biochemical changes were analysed in both groups. Results There was a reduction in mean wound healing time and an increased rate of wound contraction in the experimental group animals compared to its control group. The experimental group showed improved redox status, and histopathological findings revealed better proliferative cells, keratinisation, and epithelialization than un-irradiated controls. Conclusions Photobiomodulation therapy of dosage 4 J/cm2 enhanced the overall wound healing dynamics of the diabetes-induced neuropathic wound and optimised the oxidative status of the wound, thereby facilitating a faster healing process.

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Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy – A pilot study

Cited by 22 publications

References 28 publications

Vitamin D deficiency is associated with painful diabetic neuropathy

Vitamin D deficiency is associated with painful diabetic neuropathy

Magnesium and Pain

Effect of Photobiomodulation Therapy on Oxidative Stress Markers in Healing Dynamics of Diabetic Neuropathic Wounds in Wistar Rats

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