Effect of low-level laser therapy on bone repair: a randomized controlled experimental study

Sella, Valéria R. G.; Bomfim, Fernando Russo Costa do; Machado, Paula Carolina Dias; Morsoleto, Maria José Misael da Silva; Chohfi, Milton; Plapler, Hélio

doi:10.1007/s10103-015-1710-0

Cited by 63 publications

(55 citation statements)

References 29 publications

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“…The laser also has a positive effect on the release of cytokines and growth factors found during the various stages of bone healing [37]. The laser therapy activates osteogenic factors such as RUNX-2 and BMP-9 on bone defects [38] and increases the expression of osteocalcin [39].…”

Section: Discussionmentioning

confidence: 99%

Low-level laser therapy improves bone formation: stereology findings for osteoporosis in rat model

et al. 2015

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Low-level laser therapy (LLLT) benefits bone metabolism, but its use needs to be standardized. We evaluated the effects of LLLT on bone defects in calvaria of ovariectomized rats. Stereology was used to calculate tissue repair volume (V tr ), density of trabecular bone volume (Vv t ), total volume of newly formed trabecular bone (Vtot), and the area occupied by collagen fibers (A C ). Fifty-four Wistar rats were submitted to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups (n = 6), and 24 h after defects, the treatment started with a 780-nm low-intensity GaAlAs laser: G1, G2, and G3 received 3 sessions of 0, 20, and 30 J/cm(2) respectively; G4, G5, and G6 received 6 sessions of 0, 20, and 30 J/cm(2), respectively; and G7, G8, and G9 received 12 sessions of 0, 20, and 30 J/cm(2), respectively. A normal distribution was found for all of the data. The test used to verify the normality was the Kolmogorov-Smirnov (KS, p > 0.05). The one-way ANOVA followed by Tukey's post hoc test was used for data processing. A difference of p < 0.05 was considered statistically significant. Groups G2 and G1 showed significance for V tr , Vv t , Vtot, and (A C ). Results were significant for (Vv t ) and (Vtot) between G3 and G1. There were no significant results between G5 and G4 as well as between G8 and G7. Groups G6 and G4 results showed statistical difference for V tr , Vv t , Vtot, and (A C ). Groups G9 and G7 showed significance for V tr , Vv t , Vtot, and (A C ). In conclusion, there was new bone formation in the groups that received 20 and 30 J/cm(2) when compared to control groups, but over time, the dose of 30 J/cm(2) showed better stereological parameters when compared to 20 J/cm(2).

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Section: Discussionmentioning

confidence: 99%

Low-level laser therapy improves bone formation: stereology findings for osteoporosis in rat model

et al. 2015

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“…In fact, some studies showed that LLLT appears to stimulate mineralization in the process of new bone formation in surgically created bone defects, likely related to earlier and longer-term expression of osteocalcin and osteopontin, two proteins associated with extracellular matrix formation and osteoblast activity 24 , which is consonant with our data concerning serum levels of ALK-P. The significance of the LLLT-induced improvement in bone mineralization lies in the fact that these matrix factors contribute to the growth, shape, and size of the newly formed bone matrix 29 .…”

Section: Discussionmentioning

confidence: 99%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

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Brazil. Design of the study, histological examinations, manuscript writing, supervised all phases of the study. ABSTRACT PURPOSE:To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS:Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS:Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05). CONCLUSION:Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxaninduced diabetic rats.

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“…In addition, LLLT seems to be able to stimulate the bone mineralization and production [72][73][74][75][76]. The efficiency of the use of LD-LLLT for the treatment of MRONJ has already been investigated in six prospective studies (Table 5).…”

Section: Lllt For the Treatment Of Mronjmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Effect of low-level laser therapy on bone repair: a randomized controlled experimental study

Cited by 63 publications

References 29 publications

Low-level laser therapy improves bone formation: stereology findings for osteoporosis in rat model

Low-level laser therapy improves bone formation: stereology findings for osteoporosis in rat model

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

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