Effect of low levels of hydrotropes on micellization of phenothiazine drug

Physicochemical parameters and modes of interaction associated with the micelle formation of a mixture of tetradecyltrimethylammonium bromide and cefixime trihydrate: effects of hydrotropes and temperature

“…In the literature, several studies have revealed the mode of interaction of surfactants and HTs, emphasizing the widespread applications in antibacterial medicines. [18][19][20][21][22][23][40][41][42][43][44][45][46][47] The technological and physiological benets of mixed micelles, instead of individual surfactant systems, have shown ample scientic, commercial, and pharmacological utilizations and alternative surfactants and HTs mixtures can be developed for drug administration. 40 The surfactant's chemical composition, as well as the gel/surfactant ratio, kind of solvent, and test temperature, all had an impact on the interaction's strength and nature.…”

“…48 It was further demonstrated that the solution characteristics of the drug (ibuprofen)-surfactant mixes (sodium octyl sulfosuccinate), as well as the interactions between the drug and the surfactant were affected by the presence of both simple and hydrotropic electrolyte (aggregation parameters, interfacial properties, and thermodynamics of aggregate formation). 43 Alfai et al 41 investigated the interactions of hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) with phenothiazine drug promethazine hydrochloride (PMH) at different temperatures.…”

Effects of various media on micellization, adsorption and thermodynamic behaviour of imipramine hydrochloride and antimicrobial surfactant mixtures

“…Consequently, the cmc is also important for examining the interactions between drugs and surfactant molecules. Similar to surfactants, several amphiphilic drugs (including tricyclic antidepressants, phenothiazines and tranquillizers) also have the potential to selfassociate into micellar forms [27][28][29]. These amphiphilic drugs are classified based on their different functional groups, for example, hydrophilic and hydrophobic groups, as these groups are possibly the main reason for the therapeutic properties of the drug.…”