Effect of low-sugar and High-dietary Fiber Noodles on Glycemic Response in Healthy Humans: A Cross-over Trial

Abstract

Background: Low-carbohydrate diets are popular nutritional therapeutics based on recommendations of the American Diabetes Association (2013). In previous reports, we suggested a new diet-intake restriction method using low-sugar, high-dietary fiber noodles containing okara and konjac and reported their effect on blood glucose levels in healthy animals and animal models of type 2 diabetes. This study aimed to compare the effect of low-sugar, high-dietary fiber noodles with that of normal wheat noodles on glycemic response in healthy adult men.Methods: The study was a randomized, cross-over design to investigate the effects of normal wheat noodles versus low-sugar, high-dietary fiber noodles on glucose and insulin responses at 120 min. Plasma glucose and insulin levels were measured at 0, 15, 30, 45, 60, and 120 min after intake of normal wheat noodles or low-sugar, high-dietary fiber noodles.Results: No abnormalities and side effects were observed in the low-sugar, high-dietary fiber noodles group. Additionally, in men who consumed low-sugar, high-dietary fiber noodles, the increase in postprandial blood glucose levels and insulin levels was significantly suppressed compared with that in men who consumed normal wheat noodles. Conclusions: To the best of our knowledge, this is the first report on the effectiveness of low-sugar, high-dietary fiber noodles on postprandial blood glucose levels in healthy humans; our findings also suggest that such type of noodles might be beneficial for patients with diabetes or celiac disease who consume noodles.Trial registration: UMIN000023986

Body Weight Management in Healthy Humans Using Low-Sugar and High-Dietary Fiber Noodles : A Single Group Pre-Post Trial

“…We investigated the impact of LS-HDFNs consumption on the glycemic response in healthy individuals in a crossover trial using a single meal test. We found that subjects who consumed LS-HDFNs had signifcant attenuation of the increase in postprandial blood glucose and insulin levels compared to subjects who consumed normal wheat noodles [16]. Our results are in line with those of our previous reports.…”

“…We demonstrated the impact of LS-HDFNs consumption on blood glucose levels in type 2 diabetes mouse and rat models in previous studies [15]. In addition to these reports, we described the impact of LS-HDFNs on glycemic response in healthy individuals in a crossover trial using a single meal test and reported that individuals who consumed LS-HDFNs had signifcantly reduced postprandial blood glucose and insulin levels than healthy individuals who consumed normal wheat noodles [16]. Nevertheless, there is no experimental evidence on the body weight of healthy humans who consume LS-HDFNs for 28 days.…”

“…A previous research explored the efects of LS-HDFNs on the glycemic response in healthy individuals using a single meal test as a crossover trial. Te study found that the postprandial blood glucose and insulin levels in the LS-HDFNs group remained stable for 120 min after the consumption of LS-HDFNs [16]. Te main predisposing factors of type 2 diabetes are overweight and obesity.…”

“…Healthy Noodles TM (Kibun Foods Inc., Japan). Te details of LS-HDFNs have been previously reported in [16]. Te LS-HDFNs (180 g) had energy (kcal), proteins (g), fats (g), and carbohydrates (g) of 35.0, 2.4, 1.4, and 11.3 (sugar: 0.0, dietary fber : 11.3), respectively.…”

Consumption of fish balls “tsumire” may help prevent liver function deterioration in aged rats

“…With this background, we had previously studied the effects of food and food products on human health (Kadokura et al, 2020(Kadokura et al, , 2021a and have noted the possible beneficial effects of fish paste products used in Japanese traditional foods. In this study, we examined the effect of consumption of fish paste products used in Japanese traditional foods on aged rats and extrapolate the implications of their consumption on human health.…”