Effect of Low Temperature Cultivation on the Phytochemical Profile and Bioactivity of Arctic Plants: A Case of Dracocephalum palmatum

Оленников, Д. Н.; Чирикова, Н. К.; Кащенко, Н. И.; Gornostai, T. G.; Selyutina, I. Yu.; Зилфикаров, И. Н.

doi:10.3390/ijms18122579

Cited by 58 publications

(32 citation statements)

References 103 publications

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“…Compound 52 was identified as kaempferol- O -malonyl- O -hexoside in accordance with UV and ESI-MS spectra and literature data. The negative mass spectrum displayed a deprotonated ion [M-H] - with m / z 533, as well as demalonated fragment with m / z 447, and the aglycone fragment with m / z 285 caused the removal of a hexose particle [ 69 ]. Astragalin ( 49 ) was revealed earlier in A. eupatoria [ 55 ], A. pilosa [ 56 ], A. procera [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

Кащенко

Оленников

2020

Foods

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Functional beverages constitute the rapidly increasing part of the functional food section and represent an area with a wide range of products including herbal-based beverages. We carried out screening investigations of the extracts of 85 Rosaceous tea plants. Among the extracts analyzed Agrimonia asiatica herb extract demonstrated the highest inhibitory activity against the enzyme α-glucosidase (20.29 µg/mL). As a result of chromato-mass-spectrometric profiling of A. asiatica herb with high-performance liquid chromatography with photodiode array and electrospray triple quadrupole mass-spectrometric detection (HPLC-PDA-ESI-tQ-MS) 60 compounds were identified, including catechins, ellagitannins, flavones, flavonols, gallotannins, hydroxycinnamates, procyanidins, most for the very first time. The analysis of the seasonal variation of metabolites in A. asiatica herb demonstrated that the phenolic content was highest in summer samples and lower in spring and autumn. HPLC activity-based profiling was utilized to identify compounds of A. asiatica herb with the maximal α-glucosidase inhibitory activity. The most pronounced inhibition of α-glucosidase was observed for agrimoniin, while less significant results of inhibition were revealed for ellagic acid and isoquercitrin. The evaluation of phenolic content in A. asiatica herbal teas with the subsequent determination of α-glucosidase inhibiting potential was discovered. Maximum inhibition of α-glucosidase was observed for hot infusion (75.33 µg/mL) and the minimum for 30 min decoction (159.14 µg/mL). Our study demonstrated that A. asiatica herbal tea is a prospective functional beverage in which dietary intake may help to reduce blood glucose.

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Section: Resultsmentioning

confidence: 99%

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

Кащенко

Оленников

2020

Foods

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“…Radical scavenging activity of Fragaria extracts against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and the 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical (ABTS) was studied using microplate spectrophotometric decoloration assays as described previously [71,72]. The value of the ferric reducing antioxidant power (FRAP) was measured by spectrophotometric assay based on the reduction of the Fe 3+ -2,4,6-tri(2-pyridyl)-1,3,5-triazine complex to the ferrous form at low pH [73].…”

Section: Antioxidant Activity: In Vitro Assaysmentioning

confidence: 99%

Fragaria viridis Fruit Metabolites: Variation of LC-MS Profile and Antioxidant Potential during Ripening and Storage

2020

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Fragaria viridis Weston or creamy strawberry is one of the less-known species of the Fragaria genus (Rosaceae family) with a wide distribution in Eurasia and is still in the shadow of more popular relatives F. ananassa (garden strawberry) or F. vesca (wild strawberry). Importantly, there is a lack of scientific knowledge on F. viridis compounds, their stability in the postharvest period, and bioactivity. In this study, metabolites of F. viridis fruits in three ripening stages were characterized with high-performance liquid chromatography with photodiode array and electrospray ionization triple quadrupole mass spectrometric detection (HPLC-PAD-ESI-tQ-MS). In total, 95 compounds of various groups including carbohydrates, organic acids, phenolics, and triterpenes, were identified for the first time. The quantitative content of the compounds varied differently during the ripening progress; some of them increased (anthocyanins, organic acids, and carbohydrates), while others demonstrated a decrease (ellagitannins, flavonols, etc.). The most abundant secondary metabolites of F. viridis fruits were ellagitannins (5.97–7.54 mg/g of fresh weight), with agrimoniin (1.41–2.63 mg/g) and lambertianin C (1.20–1.86 mg/g) as major components. Antioxidant properties estimated by in vitro assays (2,2-diphenyl-1-picrylhydrazyl radical (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical (ABTS), ferric reducing antioxidant power (FRAP), and oxygen radical absorbance capacity (ORAC)) showed good antioxidant potential in all ripening stages of F. viridis fruits. The pilot human experiment on the effect of F. viridis fruit consumption on the serum total antioxidant capacity confirmed the effectiveness of this kind of strawberry. Postharvest storage of ripe fruits at 4 °C and 20 °C lead to declining content in the majority of compounds particularly ascorbic acid, ellagitannins, and flavonols, with the most significant loss at room temperature storage. These results suggest that F. viridis fruits are a prospective source of numerous metabolites that have potential health benefits.

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“…The cold climate of the northern territories promotes the accumulation of compounds such as acetylated iridoids, phenylethanoid glycosides, caffeoylquinic acids, and acylated flavone glycosides in G. bifida plants, while warm climates result in high concentrations of the non-acetylated iridoid glycosides and non-acylated flavone glucuronides. This early comparative data regarding the chemical composition of plants collected from the various regions of Siberia demonstrate greater storage ability in the northern plant populations for flavonoids [53,56,96], simple phenolics [97], ellagitannins [98], iridoids [99], caffeoylquinic acids [100], sesquiterpenes [101], and coumarins [102].…”

Section: Two Siberian Chemotypes Of G Bifidamentioning

confidence: 78%

“…Microplate spectrophotometric assays were used to study the scavenging activity of G. bifida extracts against the 2,2-diphenyl-1-picrylhydrazyl radical and the 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical, as described earlier [53,95] and the superoxide radicals scavenging capacity was determined using pyrogallol auto-oxidation assay [109]. Ferric reducing antioxidant power was determined by spectrophotometrical assay and used the reduction of the Fe 3+ -2,4,6-tri(2-pyridyl)-1,3,5-triazine complex to the Fe 2+ at low pH [110].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of Galeopsis bifida (Lamiaceae)

Оленников

2020

Plants

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Hemp nettle (Galeopsis bifida Boenn.) is a synanthropic species of the Lamiaceae family that is widely distributed across Europe, Asia, and Siberia. Galeopsis bifida is deeply embedded in the ethnomedical tradition of Asian healers; however, this plant is still poorly characterized, both chemically and pharmacologically. To study Siberian populations of G. bifida, we used high-performance liquid chromatography with photodiode array and electrospray triple quadrupole mass detection for metabolic profiling. Ninety compounds were identified, including iridoid glycosides, phenylethanoid glycosides, hydroxycinnamates, and flavone glycosides, most of which were identified in G. bifida for the first time, while some phenolics were found to have potential chemotaxonomic significance in the Lamiaceae family and Galeopsis genus. An unequal quantitative distribution of the selected metabolites was observed within separate organs of the G. bifida plant, characterized by high accumulation of most compounds within the aerial part of the plant (leaves, flowers). Analysis of the content of specific chosen compounds within the leaves of different populations of G. bifida from Eastern Siberia revealed the existence of two chemical types based on metabolic specifics: the southern type accumulates flavone glucuronides, while the northern type tends to accumulate high levels of phenylpropanoids and acylated flavone glucosides. The first study of the bioactivity of G. bifida extract demonstrated that the herb has low toxicity in acute experiments and expresses antioxidant potential against free radicals in the form of DPPH˙, ABTS˙+, and superoxide radical, as well as high ferric reducing antioxidant power, oxygen radical absorbance capacity, and protective action in the carotene bleaching assay. In general, our results suggest the herb of G. bifida as a new, prospective synanthropic plant for medical application.

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Effect of Low Temperature Cultivation on the Phytochemical Profile and Bioactivity of Arctic Plants: A Case of Dracocephalum palmatum

Cited by 58 publications

References 103 publications

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

Fragaria viridis Fruit Metabolites: Variation of LC-MS Profile and Antioxidant Potential during Ripening and Storage

Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of Galeopsis bifida (Lamiaceae)

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