Effect of low VEGF on lung development and function

Myint, May Zun Zaw; Jia, Jia; Adlat, Salah; Oo, Zin Mar; Htoo, Hsu; Hayel, Farooq; Chen, Yang; Bah, Fatoumata Binta; Sah, Rajiv Kumar; Chan, Mi Kaythi; Zhang, Luqing; Feng, Xuechao; Zheng, Yaowu

doi:10.1007/s11248-020-00223-w

Cited by 6 publications

(1 citation statement)

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“…VEGF exerts regulatory effects on the migration, survival, proliferation, and differentiation of pulmonary vascular endothelial cells. VEGFA is the primary structural component [ 17 ]. The expression levels of VEGFA are directly associated with the developmental state of pulmonary vasculature.…”

Section: Discussionmentioning

confidence: 99%

Role of regulatory T cells in mouse lung development

Jiang,

Lu,

Wang

et al. 2024

Exp. Biol. Med.

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Regulatory T cells (Tregs) constitute a specialized subset of T cells with dual immunoregulatory and modulatory functions. Recent studies have reported that Tregs mediate immune responses and regulate the development and repair processes in non-lymphoid tissues, including bone and cardiac muscle. Additionally, Tregs facilitate the repair and regeneration of damaged lung tissues. However, limited studies have examined the role of Tregs in pulmonary development. This study aimed to evaluate the role of Tregs in pulmonary development by investigating the dynamic alterations in Tregs and their hallmark cellular factor Forkhead box P3 (Foxp3) at various stages of murine lung development and establishing a murine model of anti-CD25 antibody-induced Treg depletion. During the early stages of murine lung development, especially the canalicular and saccular stages, the levels of Treg abundance and expression of Foxp3 and transforming growth factor-β (TGF-β) were upregulated. This coincided with the proliferation period of alveolar epithelial cells and vascular endothelial cells, indicating an adaptation to the dynamic lung developmental processes. Furthermore, the depletion of Tregs disrupted lung tissue morphology and downregulated lung development-related factors, such as surfactant protein C (SFTPC), vascular endothelial growth factor A (VEGFA) and platelet endothelial cell adhesion molecule-1 (PECAM1/CD31). These findings suggest that Tregs promote murine lung development.

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Section: Discussionmentioning

confidence: 99%