Effect of LPS treatment on tyrosine hydroxylase expression and Parkinson-like behaviors

Girard-Joyal, Olivier; Ismail, Nafissa

doi:10.1016/j.yhbeh.2016.12.009

Cited by 22 publications

(15 citation statements)

References 79 publications

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“…Pubertal males could be expressing increased cytokine mRNA expression earlier due to stronger deficits in BBB functioning since their immune system has not fully matured relative to their adult counterparts. The implications of BBB deficit and increased central cytokine expression are present in Parkinson‐ and schizophrenia‐like behaviour, as these types of behaviours are observed following LPS challenge during critical periods of development and particularly impact males (Girard‐Joyal and Ismail, 2017; Kohman et al, 2008; Wischhof et al, 2015). To add, the lack of heightened cytokine mRNA expression in the PFC of either pubertal or adult females suggests that female gonadal hormones play a role on the integrity of the BBB.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to shipping stress, pubertal female mice exposed to the bacterial endotoxin, lipopolysaccharide (LPS), at 6 weeks of age, display reduced sexual receptivity and behavioural responsiveness to estradiol and progesterone treatments in adulthood (Laroche et al, 2009b). The effects of pubertal LPS exposure also extend to non‐reproductive behaviors such as decreased performance on object and social recognition tests (Ismail and Blaustein, 2013), reduced open‐arm activity in the elevated plus maze (Olesen et al, 2011), and shorter latency to fall on the rotarod and reversed grid hang tests (Girard‐Joyal and Ismail, 2017), which exemplify depression‐, anxiety‐, and Parkinson‐like behaviours. The mechanisms underlying these long‐term changes remain unknown, but the results suggest that the effects are limited to the stress‐sensitive pubertal period (six weeks of age), as they are not seen in younger or older mice treated with LPS (Ismail et al, 2011; Laroche et al, 2009a,b).…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD‐1 mice

Sharma

Rooke

Kolmogorova

et al. 2018

Intl J of Devlp Neuroscience

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Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. The results showed that LPS treatment increased serum cytokine levels and sickness symptoms in all mice. Pubertal males displayed increased IL-1β concentrations at 2 h and increased IL-6 concentrations at 8 h post-treatment whereas increased concentrations of TNFα, IL-10, IL-12, IL-1β, IFNγ, and IL-6 persisted at 8 and 24 h in adult females. Consistent with peripheral cytokines, pubertal males displayed greater IL-1β, TNFα, and IL-6 mRNA expression in the prefrontal cortex at 2 h, whereas adult males expressed more of the aforementioned cytokines at 8 h compared to saline controls. Adult males also displayed greater IL-1β mRNA expression compared to their female counterparts, and adult females displayed greater TNFα mRNA expression compared to their male counterparts. These results not only provide a better understanding of the age and sex differences in acute immune response, but also show important region- and time-specific differences in the response to an immune challenge, and that the peripheral immune response differs from the central response. This highlights the need to examine immune markers in both the periphery and the central nervous system for an accurate depiction of acute immune response following an immune challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD‐1 mice

Sharma

Rooke

Kolmogorova

et al. 2018

Intl J of Devlp Neuroscience

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“…In addition, a recent study has shown that female mice were spared from the same neurodegenerative effects [58]. Microglia in mice pre-primed with LPS in vivo also caused more significant DA neuron loss, as assessed by immunohistochemistry (IHQ), following an insult by an environmental toxin.…”

Section: Pathological Hallmarks Of Pd and The Role Of Inflammationmentioning

confidence: 98%

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy

et al. 2020

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Neuroinflammation is a crucial process associated with the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Several pieces of evidence suggest an active role of lipid mediators, especially epoxy-fatty acids (EpFAs), in the genesis and control of neuroinflammation; 14,15-epoxyeicosatrienoic acid (14,15-EET) is one of the most commonly studied EpFAs, with anti-inflammatory properties. Soluble epoxide hydrolase (sEH) is implicated in the hydrolysis of 14,15-EET to its corresponding diol, which lacks anti-inflammatory properties. Preventing EET degradation thus increases its concentration in the brain through sEH inhibition, which represents a novel pharmacological approach to foster the reduction of neuroinflammation and by end neurodegeneration. Recently, it has been shown that sEH levels increase in brains of PD patients. Moreover, the pharmacological inhibition of the hydrolase domain of the enzyme or the use of sEH knockout mice reduced the deleterious effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. This paper overviews the knowledge of sEH and EETs in PD and the importance of blocking its hydrolytic activity, degrading EETs in PD physiopathology. We focus on imperative neuroinflammation participation in the neurodegenerative process in PD and the putative therapeutic role for sEH inhibitors. In this review, we also describe highlights in the general knowledge of the role of sEH in the central nervous system (CNS) and its participation in neurodegeneration. We conclude that sEH is one of the most promising therapeutic strategies for PD and other neurodegenerative diseases with chronic inflammation process, providing new insights into the crucial role of sEH in PD pathophysiology as well as a singular opportunity for drug development.

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“…with either a sterile 0.9% saline solution (control condition) or LPS (experimental condition) at a dose of 1.5 mg/kg at 6 wk old (during the stress-sensitive pubertal period) or at 10 wk old (in adulthood). This dose of LPS treatment has been found to only cause mild sickness lasting up to 48 h (7, 30) but to induce enduring changes in sexual, depression-like, anxiety-like, and Parkinson-like behaviors (8)(9)(10)(11)(12). Four weeks later, all mice were treated with LPS (1.5 mg/kg) to examine the programming effects of the adult immune response induced by pubertal immune challenge.…”

Section: Animalsmentioning

confidence: 99%

“…Exposure to an immune challenge, like the bacterial endotoxin LPS, during puberty, can cause enduring alterations in behavior, such as reduced sexual receptivity and behavioral responsiveness to estradiol and progesterone treatments in adulthood (6,7). The behavioral alterations following LPS also extend to a number of nonreproductive behaviors, like cognitive functioning (8), and depression-like (9), anxiety-like (10), and Parkinson-like (11) behaviors. These effects are limited to the stress-sensitive pubertal period (6 wk of age) (6,7,12).…”

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confidence: 99%

Programming Effects of Pubertal Lipopolysaccharide Treatment in Male and Female CD-1 Mice

Sharma

Mil

Melanson

et al. 2019

The Journal of Immunology

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Puberty is a critical period of development marked by sexual, immune, and neural maturation. Exposure to stress during this period can lead to enduring changes in brain functioning and in behavior; however, the underlying mechanisms and the programming effects of stress during puberty remain unknown. Therefore, the objective of this study was to investigate the programming effects of pubertal immune challenge in response to a homotypic stressor later in life in CD-1 mice. Age and sex differences in the peripheral and central cytokine levels, along with sickness behavior and telemetry data, were analyzed following the secondary treatment. The results showed that pretreatment with LPS attenuated the immune response to a second homotypic challenge. Males pretreated with LPS during puberty and in early adulthood displayed an attenuated hypothermic response following the second LPS treatment compared with saline-pretreated controls, which is consistent with the attenuated peripheral IL-6 and IFN-g concentrations. Females pretreated with LPS during puberty displayed lower IL-1b, TNF-a, and IL-6 mRNA expression in the prefrontal cortex following the secondary immune challenge compared with saline controls. The results of this study show that exposure to LPS during puberty programs the peripheral and central immune responses, resulting in an attenuated immune response following a subsequent homotypic stressor. Thus, exposure to an immune challenge during puberty affects immune function later in life, which could permanently affect brain function and have implications on mental health.

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Effect of LPS treatment on tyrosine hydroxylase expression and Parkinson-like behaviors

Cited by 22 publications

References 79 publications

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD‐1 mice

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD‐1 mice

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy

Programming Effects of Pubertal Lipopolysaccharide Treatment in Male and Female CD-1 Mice

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