Effect of <dfn>Orostachys spinosa </dfn> dry extract on white rat behavior in tests with positive reinforcement

Abstract

The purpose of the study to determine the Orostachys spinosa dry extract effect on the white rats behavior in tests with positive reinforcement.&#x0D; Materials and methods. The experiments were carried out on Wistar rats. The O. spinosa dry extract effect at doses of 50, 100, and 200 mg/kg on animal behavior was assessed in the hypophagy and T-maze tests.&#x0D; Results. Against the background of the O. spinosa extract introductionat doses of 100 and 200 mg/kg, the number of animals fed in the hypophagy test was 1.6 and 1.8 times greater than in the control; the feed volume exceeded by 94 and 78%, respectively, the indicator in control group animals. On the 4th day of training, a conditioned reflex was formed in 100% of the animals treated with O. spinosa extract at a dose of 200 mg/kg. Against the background of the O. spinosa extract introduction at a dose of 100 mg/kg and the reference drug, a conditioned reflex was formed in 63 and 71% of the animals, respectively, which is 2.0 times higher than in the control.&#x0D; Conclusions. The O. spinosa dry extract in doses of 100 and 200 mg/kg has a positive effect on the removal of the anxiety level, promotes an increase in orienting-exploratory activity, and thereby accelerates a conditioned reflex development in white rats.