Effect of &lt;i&gt;Dihuang rougui&lt;/i&gt; decoction on ovariectomyinduced osteoporosis in rats

Du, Mingchang; Wu, Bei; Ma, Xu; Liu, Ye; Zhai, Liang-quan; Fu, Xun; Yang, Zhen

doi:10.4314/tjpr.v17i3.6

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…1,25 (OH) 2 D 3 is considered as the key regulator of Ca homeostasis in the body. Figure 8 showed the reduction of PTH due to the observed hypercalcemia in the osteoporosis group, which further reduced the formation of 1,25 (OH) 2 D 3 in the renal tissue 1,14) . A vitamin D deficiency is defined as a 25 ( OH) D level less than 25 nmol/L.…”

Section: Discussionmentioning

confidence: 92%

“…OC, a biomarker of bone formation which is synthesised by osteoblasts and directly corresponds to their specific functions 6,14) . Upregulated or boosted level of bone formation show the osteoporosis in postmenopausal or menopausal women and our findings coincide with this view 3, 28.…”

Section: Discussionmentioning

confidence: 99%

“…Calcium is the essential nutrient for the growth of bone and teeth. Calcium plays a significant role in the maintenance and expansion of bone health and around 99％ calcium is commonly present in the bones 2 14) . Some concentration of calcium is observed in the circulation, but the amount is low and stable.…”

Section: Discussionmentioning

confidence: 99%

“…Now, with the advancement of the science, there is an easy way to treat osteoporosis. Moreover, the recent treatments have limitations such as long-term safety and e f f i c a c y 1,14) . C u r r e n t l y, h o r m o n e s a n d e s t r o g e n replacement therapy have various nonskeletal effects, including stroke, breast cancer and heart disease.…”

Section: Introductionmentioning

confidence: 99%

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Anti-osteoporosis Effect of Fisetin against Ovariectomy Induced Osteoporosis in Rats: In silico, in vitro and in vivo Activity

2022

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Osteoporosis is a bone related disease that is characterised by bone loss that further increases the susceptibility to bone fractures and bone frailty due to disturbances in the micro-architecture of bone tissue. Fisetin (flavonoids) exhibited anti-inflammatory and antioxidative stress effects against various diseases. In this protocol, we make an effort to comfort the anti-osteoporosis effect of fisetin against ovariectomy (OVX) induced osteoporosis. A docking study of fisetin and alendronate on the estrogen (α and β) and vitamin D receptors was carried out. SaOS-2 (osteoblast like human) cells were used for the estimation of cell proliferation. The OVX induced OVX model was used and three doses of fisetin and alendronate was given to rats till 16 weeks. The hormone levels, bone turnover markers and biochemical parameters were estimated. Fisetin was docked into estrogen (α and β) and vitamin D receptors, resulting in stable complexes with lower binding scores. Fisetin significantly (p < 0.001) exhibited the induction of cell proliferation against the SaOS-2 cells. OVX induced osteoporosis rats exhibited a suppression of body weight and uterus index, after the Fisetin treatment. Fisetin treatment significantly (p < 0.001) improved the level of bone mineral content (BMC), bone mineral density (BMD) and biochemical parameters such as energy, maximum load, stiffness, young modules, maximum stress and reduced the level of 1,25(OH) 2 D 3 and E 2 . Fisetin treatment significantly (p < 0.001) declined the level of phosphorus (P), calcium (Ca) and boosted the level of VitD. Fisetin treatment significantly (p < 0.001) reduced the malonaldehyde (MDA) level and enhanced the glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) level in the bone, intestine and hepatic tissue. Fisetin treatment suppressed the cytokines, RANKL/OPG ratio, receptor activator of nuclear factor-κB ligand (RANKL) and improved the level of osteoprotegerin (OPG). The findings suggest that fisetin could be a beneficial phytoconstituent for the treatment and prevention of postmenopausal osteoporotic complications.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-osteoporosis Effect of Fisetin against Ovariectomy Induced Osteoporosis in Rats: In silico, in vitro and in vivo Activity

2022

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“…Ca is the crucial player in bone health maintenance and nearly 99% of Ca is found in the bone. 54 It is well known that sufficient consumption of Ca decreases the risks of osteoporosis. The changes in the levels of Ca, P, and Cr are often reported in osteoporosis, [55][56][57][58] which already been reported that the OVX rats demonstrated the altered levels of Ca, P, and Cr in the serum.…”

Section: Discussionmentioning

confidence: 99%

Anti-osteoporosis Effect of Cynaropicrin against Ovariectomy-induced Osteoporosis in Rats

Wang

2023

Pharmacognosy Magazine

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Background Osteoporosis is a progressive bone disease, which is characterized by high bone resorption, and low bone density and mass. Osteoporosis elevates the risk of bone fragility and fracture, which leads to significant morbidity and poor life quality. Objectives The current study focuses to explore the anti-osteoporosis activity of cynaropicrin against the ovariectomized (OVX)-induced osteoporosis in rats. Methodology The OVX method was performed on the female rats to induce osteoporosis and then treated with 10 and 20 mg/kg of cynaropicrin, respectively, for 16 weeks. The uterus and femur tissues were excised from rats after the sacrification. The biomechanical properties of femur bones were analyzed to detect the stiffness, maximum load, young modulus, and energy absorption. The levels of acid phosphatase (ACP), bone-gla-protein (BGP), and estradiol (E2) in the serum were analyzed. The status of TNF-α, IL-6, IL-1β, osteoprotegerin (OPG), and receptor activator of nuclear factor-κB ligand (RANKL) was analyzed in the serum samples of experimental rats. The femur tissues were examined by histopathological analysis. Results The cynaropicrin treatment effectively increased the uterine and femoral weight in the OVX rats. The stiffness, maximum load, young modulus, energy, and femoral length were effectively increased by the cynaropicrin treatment. Cynaropicrin decreased the levels of BGP and ACP and increased the E2 level. The Cr, Ca, and P levels were appreciably increased and TNF-α, IL-6 and IL-1β levels were decreased by cynaropicrin on the OVX rats. The cynaropicrin treatment also increased the OPG and reduced the RANKL in the OVX rats. The histological findings revealed that cynaropicrin improved the femur trabecular bone microarchitecture in the OVX rats. Conclusion Our findings revealed that cynaropicrin increased the femoral weight and length, restored bone turnover markers and mineral profiles, and decreased inflammatory markers.

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A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis

Su,

Xie,

Gao

et al. 2024

NPG Asia Mater

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Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures.

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Effect of <i>Dihuang rougui</i> decoction on ovariectomyinduced osteoporosis in rats

Cited by 4 publications

References 15 publications

Anti-osteoporosis Effect of Fisetin against Ovariectomy Induced Osteoporosis in Rats: <i>In silico</i>, <i>in vitro</i> and <i>in vivo</i> Activity

Anti-osteoporosis Effect of Fisetin against Ovariectomy Induced Osteoporosis in Rats: <i>In silico</i>, <i>in vitro</i> and <i>in vivo</i> Activity

Anti-osteoporosis Effect of Cynaropicrin against Ovariectomy-induced Osteoporosis in Rats

A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis

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