Effect of &lt;i&gt;Viscum album&lt;/i&gt; (mistletoe) on some serum enzymes, weight and cytoarchitectue of the liver in high salt loaded rats

Ofem, OE; Ani, E. J.; Okongor, E Y; Okot-Asi, A; Eno, Ededet A.; Ibu, Julie

doi:10.4314/njhbs.v7i1.11653

Cited by 3 publications

(6 citation statements)

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“…Chronic consumption of salt -rich (sodium chloride) diet significantly increased serum total bilirubin, conjugated and unconjugated bilirubin concentrations. This is in line with reports by Ofem et al [27] that high salt diet increased serum bilirubin concentration. Apart from the fact that chronic consumption of sodium chloride is a risk factor for hypertension, it is evident from our study that chronic consumption of sodium chloride is also a risk factor for hyperbilirubinemia.…”

Section: Discussionsupporting

confidence: 94%

“…High levels of unconjugated bilirubin are also seen in severe haemolytic anaemia, when excessive unconjugated bilirubin overwhelms the liver's conjugating mechanisms. Increased serum conjugated bilirubin concentration on the other hand is indicative of possible biliary obstruction [27,28].…”

Section: Discussionmentioning

confidence: 99%

“…In the absence of liver damage, increased serum total bilirubin, conjugated bilirubin and unconjugated bilirubin concentration may be caused by increased rate of red blood cell formation (polycythemia), hemolysis; as seen in ineffective erythropoiesis, or from deficient bilirubin transport across the liver as presented in Gilbert's syndrome [28]. In a study conducted by Ofem et al [27], high salt-diet was associated with liver damage. He further reported that photomicrograph of a section of the liver in high salt fed group showed marked necrotic condition, pyknosis, karyorrhexis, numerous but deranged sinusoids, with many pockets of lipid deposits similar to that of alcoholic syndrome, signifying degeneration of the hepatocytes [27].…”

Section: Discussionmentioning

confidence: 99%

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Reduction in Serum Bilirubin Concentration Following Administration of Crude Leaf Extract of Viscum album (Mistletoe) in High Salt Fed Rats

Effiong

2014

BJPR

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Aims: This study was designed to determine the effect of a high salt diet on serum bilirubin concentration and to ascertain the impact of treatment with Viscum album on same. Methodology: Twenty male albino wistar rats weighing 150 -200g were used for this study. After seven days of habituation, the animals were randomly divided into four (4) groups of five rats each. Group 1 (NC) served as control and were fed with normal rat pellet and water; group 2(NT) served as the control treated group (administered 150 mg/kg Viscum album orally, in addition to rat pallet and water); group 3 (SF) served as the high salt diet fed group (without treatment), while group 4 (ST) served as the high salt diet fed group, treated orally with 150 mg/kg Viscum album. The feeding regimen lasted for six weeks, after which the animals were sacrificed and blood samples collected for analysis. Results: Mean serum total bilirubin concentration was significantly (p<0.001) higher in the SF group compared to control, NT and ST group. It was also significantly (p<0.001) lower

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reduction in Serum Bilirubin Concentration Following Administration of Crude Leaf Extract of Viscum album (Mistletoe) in High Salt Fed Rats

Effiong

2014

BJPR

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“…Previous studies have shown a negative impact of long-term consumption of HFD and HSD on hematological parameters [83, [113][114][115]. This study investigated whether short-term intake of HFD or HSD has a more detrimental effect on hematological parameters.…”

Section: Discussionmentioning

confidence: 97%

Assessing the short-term impact of a high-fat, high-salt diet on the gut bacteria and related pathophysiology in mice

Kumar,

Pandey,

Chang

et al. 2023

Preprint

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Current research shows that consuming high-fat and salt that are now the main ingredients of modern diets over a period of time can disrupt the gut ecosystem, leading to metabolic imbalances and metabolic diseases. However, which component of modern diets, such as high-fat and high-salt consumption for a short duration, is more harmful to health based on its impact on gut bacteria and associated health outcomes is still poorly explored. This study aimed to determine which of high fat or high salt is more detrimental to health by feeding mice HFD and HSD diets for a short period of 3 weeks. To address these wide knowledge gaps, we conducted a high-throughput sequencing study to see how gut microbiota profile changes in HFD or HSD-fed mice. Further, we also investigated whether high fat or high salt is more detrimental to health. In this study, the mice were fed a standard chow diet (CD), HFD and HSD for 3 weeks. Animals were euthanized and examined of haemato-biochemical and histopathological attributes. We also used 16S rRNA sequencing followed by bioinformatics analysis to evaluate the changes in gut microbiota ecology. Interestingly, this study found that HFD or HSD feeding for a short duration induces the pathophysiological attributes of a typical metabolic syndrome as indicated by serum biochemistry and significantly modifies gut microbiota in mice. We concluded that HSD causes significantly more changes in gut bacteria than HFD due to a diminution of beneficial gut bacteria and an enrichment of harmful gut bacteria. We found that HFD led to a more significant increase in plasma total cholesterol (TC), a known risk factor for heart disease, stroke, and atherosclerosis. While HSD is more detrimental to the kidneys, since an increase in creatinine levels indicates kidney disease. Furthermore, mice fed HFD or HSD for a short duration showed minimal and insignificant pathological changes in their hearts, livers, and kidneys.

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“…High salt intake has been reported as one of the causes of liver cirrhosis (Suki and Massry, 1990;Ofem et al, 2008). The increased level of globulin in the salt-fed rats would possibly be due to liver production of globulin sequel to cirrhosis from excessive salt loading.…”

Section: Parametersmentioning

confidence: 97%

Viscum album (mistletoe) extract prevents changes in levels of red blood cells, PCV, Hb, serum proteins and ESR in high salt-fed rats

Ofem

Eno

Nku

et al. 2009

Journal of Ethnopharmacology

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Effect of <i>Viscum album</i> (mistletoe) on some serum enzymes, weight and cytoarchitectue of the liver in high salt loaded rats

Cited by 3 publications

References 0 publications

Reduction in Serum Bilirubin Concentration Following Administration of Crude Leaf Extract of Viscum album (Mistletoe) in High Salt Fed Rats

Reduction in Serum Bilirubin Concentration Following Administration of Crude Leaf Extract of Viscum album (Mistletoe) in High Salt Fed Rats

Assessing the short-term impact of a high-fat, high-salt diet on the gut bacteria and related pathophysiology in mice

Viscum album (mistletoe) extract prevents changes in levels of red blood cells, PCV, Hb, serum proteins and ESR in high salt-fed rats

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