Effect of lubricating eyedrops on ocular light scattering as a measure of vision quality in patients with dry eye

Abstract

No author has a financial or proprietary interest in any material or method mentioned.

Longitudinal Assessment of Optical Quality and Intraocular Scattering Using the Double-Pass Instrument in Normal Eyes and Eyes with Short Tear Breakup Time

“…Diaz-Valle et al [16] reported that no significant differences were found in intraocular scattering over a 20-second period, which was consistent with our findings. To our knowledge, this is the first published study to assess the detailed optical quality parameters using the double-pass method, such as the MTF cutoff frequency and the Strehl ratio, which are considered to have a large impact on visual performance.…”

“…Our results are in line with those reported in dry eye patients by Diaz-Valle et al [16] It is suggested that an unstable tear film may play a role in enhancing ocular scattering in eyes with short TBUT, and that these change rates are potential indicators for differentiating short-TBUT eyes from normal eyes. A more detailed analysis should be performed to determine the exact role of the change rate of optical quality in eyes with short TBUT.…”

“…Further studies are required to determine optical quality parameters in the tear film dynamics under several pupil size conditions. Second, in our study using the double-pass technique, we measured optical quality at 5-second intervals over 10 seconds without blinking, whereas recent studies were performed every 0.5-second intervals over 20 seconds [15], [16]. However, in order to simply compare short TBUT subjects with normal subjects, we evaluated 3 measurement points (initial examination, 5, and 10 seconds after the blink).…”

“…The Optical Quality Analysis System (OQAS, Visiometrics, Terrassa, Spain) was designed for use in clinical practice to objectively determine the optical quality, including intraocular scattering, of the human eye using a double-pass technique. There have been only a few studies on tear film-related optical quality using this device in normal subjects or dry eye patients [14]–[16]. However, to our knowledge, there have so far been no clinical studies on detailed optical quality parameters, such as modulation transfer function (MTF) cutoff frequency and Strehl ratio, using the double-pass system.…”

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

“…[31][32][33][34][35][36][37][38][39][40][41][42] Moreover, the double-pass system is capable of monitoring postblink dynamic changes in optical quality associated with changes in the tear film. [43][44][45][46][47] Previous investigations using sequential HOA measurements showed that postblink dynamic changes in optical quality occur even in clinically normal subjects and revealed that such postblink changes in dry eyes can be classified into two patterns. 33,38,39 In dry eyes with a decreased tear film break-up time and dry eye symptoms without ocular surface damage and tear deficiency, the HOA pattern exhibited an upward curve after blinking that continued to increase.…”