Effect of luteolin on apoptosis, MAPK and JNK signaling pathways in guinea pig chondrocyte with osteoarthritis

Abstract

Osteoarthritis (OA) is a degenerative joint disease usually seen in the elderly, which incidence increases with age. Its pathogenesis and underlying mechanism are still unclear. The disease severely affects the physical health and life quality of patients, thereby constituting a huge economic burden to family and society. Luteolin (LUT) is a natural flavonoid with multiple pharmacological properties. Many plants containing LUT have been applied in the treatment of several inflammation-related diseases due the relatively strong anti-inflammatory effects of LUT. The present study investigated the influence of LUT on cell apoptosis and inflammatory reactions in cartilage of OA guinea pigs, and its underlying mechanism. It was found that LUT effectively inhibited proliferation of OA cartilage cells, down-regulated the expressions of JNK and p38MAPK in cartilage cells of OA, and downregulated NO, TNF-α and IL-6. Thus, it alleviated inflammatory reactions, protected cartilage cells, and delayed cartilage degeneration.

Mechanism of Salviae Miltiorrhizae Radix et Rhizoma in the treatment of knee osteoarthritis based on network pharmacology

“…Luteolin is a natural avonoid compound that exists in a variety of plants and has a various pharmacological activities, such as anti-in ammatory, anti-allergic, and uric acid activity. Studies have shown that luteolin can reduce in ammation, protect chondrocytes, and delay cartilage degradation, which may be achieved by inhibiting the proliferation of OA chondrocytes and downregulating the expression of JNK and p38 MAPK in OA chondrocytes [29]. Similarly, luteolin can reduce IL-1β-induced in ammatory factor production and inhibit IL-1β-induced NF-κB phosphorylation, as shown by reducing cartilage destruction in OA rats [30].…”

Olea europaea Suppresses Inflammation by Targeting TAK1-Mediated MAP Kinase Activation

“…QCN suppresses JNK/AP-1 signaling in a time-dependent manner in acetaminophen-induced liver damage [ 31 ]. Additionally, luteolin can effectively reduce proliferation of osteoarthritis cartilage cells, suppress the expression of JNK and p38 in cartilage cells, and inhibit the production of NO, TNF-α, and IL-6 [ 32 , 33 ]. Luteolin suppresses phosphorylation of ERK in the MAPK signaling pathway to induce apoptosis in the gastric cancer cell line BGC-823 [ 34 ].…”

“…Luteolin suppresses phosphorylation of ERK in the MAPK signaling pathway to induce apoptosis in the gastric cancer cell line BGC-823 [ 34 ]. Based on these reports [ 31 , 32 , 33 , 34 ], it is considerable that QCN, KFL, and luteolin could be major components in suppression of the MAPK pathway. In addition, we have also identified that oleuropein and hydroxytyrosol are included almost 50% and 4.3% of phenolic compounds in olive leaves [ 35 ].…”

Network pharmacology-based analysis of Zukamu granules for the treatment of COVID-19

“…Luteolin, a natural flavonoid, has a significant anti-inflammatory effect, and its mechanism is related to the MAPK signaling pathway. Besides, luteolin has a role in reducing lung injury and myocardial fibrosis [36] , [37] , [38] . Beta-sitosterol has anti-inflammatory effects by inhibiting the occurrence of inflammatory reactions [ 39 , 41 ].…”