Effect of macrocyclic lactones on nontarget coprophilic organisms: a review

Junco, Milagros; Iglesias, Lucía; Sagüés, María Federica; Guerrero, Inés; Zegbi, Sara; Saumell, Carlos

doi:10.1007/s00436-021-07064-4

Cited by 24 publications

(22 citation statements)

References 56 publications

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“…The emergence of both Coleoptera and Diptera was significantly lower from mesocosms spread with the ivermectin‐treated manure than control manure. This suggests that the negative effects of ivermectin residues in cattle dung from animals treated with veterinary parasiticides (reviewed by Floate et al ., 2005 and Junco et al ., 2021) remain concerning even in manure aged in the field. However, the concentrations of ivermectin used in this study were at the upper limit of those reported in the literature for naturally excreted cattle faeces, and further studies with a range of concentrations would be useful to examine impacts across the excretion profile (Herd et al ., 1996; Sommer et al ., 1992; Lumaret et al ., 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The impacts of veterinary parasiticide residues in dung on important decomposer insect communities such as dung beetles and flies are well studied (Floate et al ., 2005; Finch et al ., 2020; Junco et al ., 2021). The macrocyclic lactone ivermectin has been shown to be excreted in dung at concentrations that are toxic to insects for 28, 35 and at least 49 days after treatment with pour‐on, injectable and sustained release bolus formulations, respectively (Herd et al ., 1996).…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of ivermectin residues in aged farmyard manure to terrestrial and freshwater invertebrates

Sands

Noll

2021

Insect Conserv Diversity

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1. Farmyard manure is often stored, aged and spread on fields as fertiliser; however, dung may be contaminated with residues of veterinary endectocides used to treat livestock for parasites. The persistence of these chemicals during storage and impact on invertebrate biodiversity after spreading are not well understood.2. This study considered whether residues in aged cattle manure could have impacts on terrestrial and freshwater invertebrate biodiversity and ecosystem function.3. Fresh cattle dung was spiked with known concentrations of the endectocide ivermectin or an excipient only (control) and aged in the field for 4 months between February and May 2020. Each month rainwater run-off was collected and used to examine toxicity using the freshwater invertebrate Daphnia magna. In June 2020, manure was spread on mesocosms containing topsoil, and above-ground insect emergence, soil fauna feeding rate, earthworm abundance and pasture productivity (perennial ryegrass growth), were measured over 10 weeks.4. Rainwater-runoff from manure contaminated with ivermectin was highly toxic (60-100% mortality) to D. magna for the entire 4 months of storage. Coleoptera and Diptera emergence was lower from mesocosms spread with ivermectin-contaminated manure compared with control manure. Pasture productivity was significantly lower (18-20%) in mesocosms spread with ivermectin-contaminated manure.5. The results indicate that ivermectin residues aged manure have the potential to retain toxic effects on terrestrial and freshwater invertebrates for at least 4 months of storage, could reduce pasture productivity, and may have pervasive impacts on invertebrate biodiversity in agricultural systems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicity of ivermectin residues in aged farmyard manure to terrestrial and freshwater invertebrates

Sands

Noll

2021

Insect Conserv Diversity

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“…Thus, approximately 2500-7700 μg of Ivermectin kg À1 of dry dung are excreted during the first 7 days after treatment (Wohde et al, 2016), an amount high enough to harm non-target organisms involved in pasture functioning (Junco et al, 2021;Lumaret et al, 2012;Verdú et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore it is excreted in its active form in dung (Campbell, 1989), where its chemical structure and pesticide activity can remain stable after 60 days (Iwasa et al, 2005; Jochmann & Blanckenhorn, 2016). Thus, approximately 2500–7700 μg of Ivermectin kg −1 of dry dung are excreted during the first 7 days after treatment (Wohde et al, 2016), an amount high enough to harm non‐target organisms involved in pasture functioning (Junco et al, 2021; Lumaret et al, 2012; Verdú et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ivermectin impacts on dung beetle diversity and their ecological functions in two distinct Brazilian ecosystems

Correa

Ferreira

Abot

et al. 2022

Ecological Entomology

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The indiscriminate use of Ivermectin is becoming a frequent scenario in Brazil, one of the largest beef cattle herds in the world, and the second‐highest commercial production, despite this product having harmful effects on non‐target organisms. Among these organisms, dung beetles are essential for the maintenance of ecosystem functioning in introduced pastures. This study evaluated the effects of Ivermectin on dung beetle assemblage attributes (species richness, abundance, species composition, functional groups and indicator species) as well as their ecological functions (dung removal and soil bioturbation) in introduced pastures with different priorities for livestock intensification in Brazil; Amazon (high) and Pantanal (low). We found a negative response of dung beetle assemblages to Ivermectin in both Brazilian ecosystems, where these negative effects were more pronounced in the Pantanal. Tunneler beetles are the functional group most negatively affected in both ecosystems. Finally, the Ivermectin reduces the ecological functions performed by dung beetles, with a dung removal reduction of ca. 50% and 70% in the Amazon and Pantanal, respectively. The most negative impacts in the Brazilian Pantanal reflect the long‐term consequences due to a long history of Ivermectin use than in the Amazon. However, these results also indicate a drastic future for dung beetles in Amazonian pastures. Thus, a sustainable cattle production system reducing Ivermectin use will be important for conserving dung beetles on introduced Brazilian pastures and the ecological functions that these insects provide in livestock‐dominated landscapes.

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“…Extensive reviews by Liebig et al [ 33 ], Lumaret et al [ 41 ], Finch et al [ 42 ], and Junco et al [ 43 ] summarize environmental risks accompanying the unintentional release of macrocyclic lactones and are cause for concern. Acute and chronic effects are observed especially for coprophagous species.…”

Section: Introductionmentioning

confidence: 99%

Sorption of selected antiparasitics in soils and sediments

et al. 2021

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Background Veterinary pharmaceuticals can enter the environment when excreted after application and burden terrestrial and aquatic ecosystems. However, knowledge about the basic process of sorption in soils and sediments is limited, complicating regulatory decisions. Therefore, batch equilibrium studies were conducted for the widely used antiparasitics abamectin, doramectin, ivermectin, and moxidectin to add to the assessment of their environmental fate. Results We examined 20 soil samples and six sediments from Germany and Morocco. Analysis was based on HPLC-fluorescence detection after derivatization. For soils, this resulted in distribution coefficients KD of 38–642 mL/g for abamectin, doramectin, and ivermectin. Moxidectin displayed KD between 166 and 3123 mL/g. Normalized to soil organic carbon, log KOC coefficients were 3.63, 3.93, 4.12, and 4.74 mL/g, respectively, revealing high affinity to organic matter of soils and sediments. Within sediments, distribution resulted in higher log KOC of 4.03, 4.13, 4.61, and 4.97 mL/g for the four substances. This emphasizes the diverse nature of organic matter in both environmental media. The results also confirm a newly reported log KOW for ivermectin which is higher than longstanding assumptions. Linear sorption models facilitate comparison with other studies and help establish universal distribution coefficients for the environmental risk assessment of veterinary antiparasitics. Conclusions Since environmental exposure affects soils and sediments, future sorption studies should aim to include both matrices to review these essential pharmaceuticals and mitigate environmental risks from their use. The addition of soils and sediments from the African continent (Morocco) touches upon possible broader applications of ivermectin for human use. Especially for ivermectin and moxidectin, strong sorption further indicates high hydrophobicity and provides initial concern for potential aquatic or terrestrial ecotoxicological effects such as bioaccumulation. Our derived KOW estimates also urge to re-assess this important regulatory parameter with contemporary techniques for all four substances. Graphic abstract

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Effect of macrocyclic lactones on nontarget coprophilic organisms: a review

Cited by 24 publications

References 56 publications

Toxicity of ivermectin residues in aged farmyard manure to terrestrial and freshwater invertebrates

Toxicity of ivermectin residues in aged farmyard manure to terrestrial and freshwater invertebrates

Ivermectin impacts on dung beetle diversity and their ecological functions in two distinct Brazilian ecosystems

Sorption of selected antiparasitics in soils and sediments

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