Effect of macronutrient and micronutrient manipulation on avian blood glucose concentration: A systematic review

Basile, Anthony J.; Singh, Kavita C.; Watson, Deborah F.; Sweazea, Karen L.

doi:10.1016/j.cbpa.2022.111279

Cited by 8 publications

(3 citation statements)

References 61 publications

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“…Additionally, intraspecific data indicates that changes in diet composition hardly affects glycaemia in birds [75]. Together, these studies suggest that glycaemia is tightly regulated independently of dietary composition.…”

Section: Terrestrial Carnivores Show a Paradoxically Increased Albumi...mentioning

confidence: 70%

“…Nevertheless, this aligns with results previously reported by [13] for Passeriformes or by [52] for 160 species of vertebrates among which 48 were birds. Additionally, intraspecific data indicates that changes in diet composition hardly affects glycaemia in birds [75]. Together, these studies suggest that glycaemia is tightly regulated independently of dietary composition.…”

Section: Discussionmentioning

confidence: 99%

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Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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The pace of life hypothesis (POL) suggests that organisms’ life history, physiological and behavioural traits should co-evolve. In this context, glycaemia (i.e., blood glucose levels) and its consequences to ageing through its reaction with proteins and other compounds (i.e. glycation) constitute physiological traits which remain under-investigated in an evolutionary comparative framework, notably in relation to life history traits and ecological factors. Although their blood glucose levels are twice as high as in mammals, birds live longer when accounting for their body mass. We thus performed a comparative analysis on glucose and albumin glycation rates on 87 bird species from 22 orders, in relation to life history traits (body mass, clutch mass, maximum lifespan and developmental time) and diet. Glucose levels correlated positively with albumin glycation rates in a non-linear fashion, suggesting resistance to glycation in species with higher glucose levels. Plasma glucose levels decreased with increasing body mass and increased with maximum lifespan before reaching a plateau. Finally, terrestrial carnivores showed higher albumin glycation compared to omnivores. Our results open an important new avenue of research to help us to better understand the striking condition of hyperglycaemic yet long-lived birds.

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Section: Terrestrial Carnivores Show a Paradoxically Increased Albumi...mentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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show abstract

“…Therefore, we believe that MDA mostly derives from cell membrane lipids rather than from dietary triglycerides in our samples. Finally, a recent review found that diet macro- and micronutrient manipulations generally have no effect on blood glucose levels in birds (Basile et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Songbirds avoid the oxidative stress costs of high blood glucose levels

Vágási

Vincze

Adámková

et al. 2023

Preprint

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Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided at the macroevolutionary scale by adaptations in oxidative physiology. However, this hypothesis remains unexplored. Here we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species. We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no or weak evidence for blood glucose concentration coevolving with either antioxidant or lipid damage levels. The only exceptions were the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings essentially support the hypothesis that birds evolved adaptations preventing the putative (glyc)oxidative costs of high blood glucose. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds, and possibly the paradoxical combination of long lifespan and high blood glucose levels in birds relative to mammals.Summary statementHigh blood glucose levels can harm organisms by causing oxidative stress. We show that birds defy this expectation. Avian physiology could provide solutions for diabetes treatment.

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Acute metformin induces hyperglycemia in healthy adult mourning doves, Zenaida macroura

Basile,

Kreisler,

Hassen

et al. 2024

Comparative Biochemistry and Physiology Part A: Molecular &

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Effect of macronutrient and micronutrient manipulation on avian blood glucose concentration: A systematic review

Cited by 8 publications

References 61 publications

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Songbirds avoid the oxidative stress costs of high blood glucose levels

Acute metformin induces hyperglycemia in healthy adult mourning doves, Zenaida macroura

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