Effect of macrophages on <i>in vitro</i> corrosion behavior of magnesium alloy

Zhang, Jian; Hiromoto, Sachiko; Yamazaki, Tomohiko; Niu, Jialin; Huang, Hua; Jia, Gaozhi; Li, Haiyan; Ding, Wei; Yuan, Guangyin

doi:10.1002/jbm.a.35788

Cited by 34 publications

(19 citation statements)

References 38 publications

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“…These results confirm the model of cell‐accelerated corrosion proposed by Gilbert et al suggesting that macrophages release reactive oxygen species under inflammatory conditions and thus promote corrosion . One of the potential reactive oxygen species occurring in vivo is H 2 O 2 .…”

Section: Discussionsupporting

confidence: 90%

In Vitro Evidence for Cell‐Accelerated Corrosion Within Modular Junctions of Total Hip Replacements

Bijukumar

Salunkhe

Morris

et al. 2019

Journal Orthopaedic Research

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Corrosion at modular junctions of total hip replacement (THR) remains a major concern today. Multiple types of damage modes have been identified at modular junctions, correlated with different corrosion characteristics that may eventually lead to implant failure. Recently, within the head-taper region of the CoCrMo retrieval implants, cell-like features and trails of etching patterns were observed that could potentially be linked to the involvement of cells of the periprosthetic region. However, there is no experimental evidence to corroborate this phenomenon. Therefore, we aimed to study the potential role of periprosthetic cell types on corrosion of CoCrMo alloy under different culture conditions, including the presence of CoCrMo wear debris. Cells were incubated with and without CoCrMo wear debris (obtained from a hip simulator) with an average particle size of 119 ± 138 nm. Electrochemical impedance spectroscopy (EIS) was used to evaluate the corrosion tendency, corrosion rate, and corrosion kinetics using the media after 24 h of cell culture as the electrolyte. Results of the study showed that there was lower corrosion resistance (p < 0.02) and higher capacitance (p < 0.05) within cell media from macrophages challenged with particles when compared with the other media conditions studied. The potentiodynamic results were also in agreement with the EIS values, showing significantly higher corrosion tendency (low E corr ) (p < 0.0001) and high I corr (p < 0.05) in media from challenged macrophages compared with media with H 2 O 2 solution. Overall, the study provides in vitro experimental evidence for the possible role of macrophages in altering the chemical environment within the crevice and thereby accelerating corrosion of CoCrMo alloy.

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Section: Discussionsupporting

confidence: 90%

In Vitro Evidence for Cell‐Accelerated Corrosion Within Modular Junctions of Total Hip Replacements

Bijukumar

Salunkhe

Morris

et al. 2019

Journal Orthopaedic Research

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“…Rolling (hot/cold), extrusion, equal-channel angular pressing (ECAP), high pressure torsion (HPT), drawing, forging are the most commonly-used process methods for BMs' properties enhancement. It has been reported that these severe plastic deformation methods have dramatically improved the mechanical strength [82][83][84][85], elongation [82,83,85], vickers' hardness [86][87][88], corrosion behavior [86,[89][90][91], biocompatibility [92] of BMs. Clearly these are adoptable and promising techniques for Zn-based BMs in the future.…”

Section: Hot/cold Workingmentioning

confidence: 99%

Progress of biodegradable metals

Zheng

Qin

2014

Progress in Natural Science: Materials International

359

160

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Biodegradable metals (BMs) are metals and alloys expected to corrode gradually in vivo, with an appropriate host response elicited by released corrosion products, then dissolve completely upon fulfilling the mission to assist with tissue healing with no implant residues. In the present review article, three classes of BMs have been systematically reviewed, including Mg-based, Fe-based and Zn-based BMs. Among the three BM systems, Mg-based BMs, which now have several systems reported the successful of clinical trial results, are considered the vanguards and main force. Fe-based BMs, with pure iron and Fe-Mn based alloys as the most promising, are still on the animal test stage. Zn-based BMs, supposed to have the degradation rate between the fast Mg-based BMs and the slow Fe-based BMs, are a rising star with only several reports and need much further research. The future research and development direction for the BMs are proposed, based on the clinical requirements on controllable degradation rate, prolonged mechanical stability and excellent biocompatibility, by optimization of alloy composition design, regulation on microstructure and mechanical properties, and following surface modification.

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“…Zhang et al [97] studied the influence of macrophages on the biocorrosion of Mg-2.1Nd-0.2Zn-0.5Zr (abbreviated as JDBM). Macrophages were found to substantially increase the corrosion rate of this alloy, owning to the deposition of ROS onto the samples' surface.…”

Section: Macrophagesmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Effect of macrophages on in vitro corrosion behavior of magnesium alloy

Cited by 34 publications

References 38 publications

In Vitro Evidence for Cell‐Accelerated Corrosion Within Modular Junctions of Total Hip Replacements

In Vitro Evidence for Cell‐Accelerated Corrosion Within Modular Junctions of Total Hip Replacements

Progress of biodegradable metals

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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