Effect of Magnesium as Biomaterial in Biodegrdation

Abraham, Adarsh Mathew; Sathesh, Venkatesan

doi:10.1016/j.matpr.2023.05.424

Cited by 2 publications

(1 citation statement)

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“…Material degradation significantly impacts the successful performance of magnesium materials [ 3 , 13 ]. Rapid degradation can lead to excessive hydrogen (H 2 ) evolution, potentially harming surrounding tissues [ 284 , 320 ]. The design and clinical application of magnesium implants must carefully take gas cavity formation into account.…”

Section: The Use Of Magnesium In Biomaterialsmentioning

confidence: 99%

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan,

Krieg,

Kopp

et al. 2024

IJMS

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Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models.

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