Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine,<scp>d</scp>-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan

Iezhitsa, Igor Nikolayevich; Spasov, A. A.; Kharitonova, Maria; Kravchenko, M. S.

doi:10.1179/174313211x12966635733277

Cited by 33 publications

(25 citation statements)

References 48 publications

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“…However, the two groups had no difference in regard to cardiopulmonary bypass items, surgical variables, or anesthetic parameters; this indicated that the underlying clinical situations for the study were largely identical in the two groups. Magnesium may 'modulate cellular inflammation' while 'suppressing the inflammatory role of inflammatory cells and cytokines' (34, 35) through the 'activation of N-methyl-d-aspartate (NMDA) receptors', 'phosphoinositide 3-kinase/Akt pathway' and suppression of inflammatory neuromediators through the activation of 'neuro-endocrinological pathways' as the main mechanisms; since, magnesium is a natural antagonist of calcium ion (3-6, 30, 35-37, 42). The inflammatory response after CBP is one of the most significant side effects of this surgical intervention, and a number of compensatory mechanisms and approaches have been proposed, though many remain equivocal (1, 2, 10, 12, 27, 45-49).…”

Section: Discussionmentioning

confidence: 99%

“…Since, magnesium is a natural antagonist of calcium ion and MgSO4, which acts through inhibition of 'N-methyl-D-aspartate dependent cellular pathways'(3-6, 30, 35, 36). On the other hand, it has been demonstrated that decreased plasma levels of magnesium can activate inflammatory neuromediators via the activation of 'neuroendocrinological pathways (37). At the same time, other studies have demonstrated that NF-kappaB activation with simultaneous suppression ofendotoxin, induces an increase in inflammatory mediators due to magnesium infusion in animals; furthermore, these mechanisms possibly work in a similar way in coronary artery bypass graft (CABG) patients (3-6, 34, 38-43).…”

Section: Objectivesmentioning

confidence: 99%

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Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass

et al. 2014

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Background:Cardiovascular problems are among the most common health issues. A considerable number of cardiac patients undergo cardiac surgery, and coronary artery disease patients constitute about two-thirds of all these surgeries. The application of cardiopulmonary bypass (CBP) usually results in some untoward effects.Objectives:Studies have suggested magnesium sulfate (MgSO4) as an anti-inflammatory agent in a coronary artery bypass graft (CABG). This study aimed to assess the effect of an IV MgSO4 infusion during elective CABG (with CBP) on the blood levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α).Materials and Methods:During a 12 month period, after review board approval and based on inclusion and exclusion criteria, 90 patients were selected and entered randomly into one of the two study groups (MgSO4 or placebo). Anesthesia, surgery and CBP were performed in exactly the same way, except for the use of MgSO4 or a placebo. Both preoperative and postoperative plasma levels of IL-6 and TNF-α were checked and compared between the two groups using an ELISA.Results:There was no difference found between the two groups with regard to; gender, basic variables, Ejection Fraction (EF), CBP time and aortic cross-clamp time. The preoperative levels of IL-6 and TNF-α were not different; however, their postoperative levels were significantly higher in the placebo group (P value = 0.01 for IL-6 and 0.005 for TNF-α).Conclusions:This study showed that MgSO4 infusion could suppress part of the inflammatory response after CABG with CBP. This was demonstrated by decreased levels of interleukin-6 and TNF-α in postoperative serum levels in elective CABG with CBP.

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Section: Discussionmentioning

confidence: 99%

Section: Objectivesmentioning

confidence: 99%

Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass

et al. 2014

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“…To evaluate the Mg concentration, a two ml sample of heparinized venous blood was collected every week from the sublingual vein while the rats were under isoflurane anaesthesia [42]. RBC and plasma Mg levels were measured via a previously described colorimetric assay method in which Mg is stained using thiazole yellow [43]. After Mg concentration in rats fed the low Mg diet had decreased, the animals were treated with one of the following supplementations: Mg L-aspartate, Mg N-acetyltaurate, Mg chloride or Mg sulphate (50 mg of elementary Mg per kg body weight for 14 days).…”

Section: Oxidative Stress and Magnesium Deficiencymentioning

confidence: 99%

Magnesium deficiency and oxidative stress: an update

Желтова¹,

Kharitonova²,

Iezhitsa³

et al. 2016

BioMed

167

102

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Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened antioxidant defence. Different mechanisms associated with MgD are involved in the development and maintenance of OS. These mechanisms include systemic reactions such as inflammation and endothelial dysfunction, as well as changes at the cellular level, such as mitochondrial dysfunction and excessive fatty acid production.

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“…Blood plasma and brain Mg levels are also significantly correlated with anxiety-related behavioral responses in rodents [44]. Supplementing Mg levels in mice has been demonstrated to reduce the expression of anxiety-related behavior [30,45]. …”

Section: Introductionmentioning

confidence: 99%

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

2017

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Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.

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Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine,d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan

Abstract: Combination of Mg salts and pyridoxine hydrochloride can be effective at treating some behavior form of primary Mg deficiency.

Cited by 33 publications

References 48 publications

Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass

Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass

Magnesium deficiency and oxidative stress: an update

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

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