Effect of Magnesium Deficiency on Various Mineral Concentrations in Rat Liver

Kim, Ki‐Hyun; Ishizaki, Natsumi; Iguchi, Erika; Funaba, Masayuki; Matsui, Tohru

doi:10.1007/s12011-011-9042-9

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…Comprehensive analyses of the minerals were performed using an ICP-MS (Elan6000, Perkin Elmer, Norwalk, CT) in semi-quantification mode (TotalQuant III). 7 A total of 26 minerals was evaluated by this metallomic analysis. The results were visualized by a two-dimensional graphical representation of the mineral contents in red and green using Treeview.…”

Section: Metallomic Analyses and Quantification Of Mnmentioning

confidence: 99%

Reduction of liver manganese concentration in response to the ingestion of excess zinc: identification using metallomic analyses

et al. 2012

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To date, minerals of interest have been analyzed individually to understand mineral dynamics and metabolism. Our recent development of metallomic analyses enabled us to evaluate minerals in an unbiased and global manner. Here, we evaluated effects of the ingestion of excess zinc on the plasma and tissue concentrations of minerals in growing rats. A total of 26 minerals were simultaneously evaluated by the metallomic analyses using an inductively-coupled plasma-mass spectrometry in semi-quantification mode; the concentrations of several minerals exhibited consistent changes in response to the concentration of dietary zinc. The manganese concentrations in plasma and femur were increased, whereas those in the liver and pancreas were decreased with increasing dietary zinc concentrations. Because the interaction between zinc and manganese has not been known, we further focused our analysis on liver manganese. Quantitative analyses also indicated that the hepatic concentration of manganese decreased in response to the ingestion of diets containing excess zinc, a result that was partly explained by the decreased expression of hepatic Zip8, a manganese transporter. The present study reveals a mineral interaction using metallomic analyses and proposes a possible mechanism underlying the novel interaction.

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Section: Metallomic Analyses and Quantification Of Mnmentioning

confidence: 99%

Reduction of liver manganese concentration in response to the ingestion of excess zinc: identification using metallomic analyses

et al. 2012

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“…Lipid metabolism activity decline, impaired lipid metabolism regulation and signal transmission from adrenergic receptors leads to energy metabolism intensity decline and blood plasma lipid imbalance. In particular, hypomagnesaemia inevitably leads to the increase in the levels of plasma triglycerides (due to decreased activity of genes ACSM1, 2, 3, 4, 5 and 6; ACSL1, 2, 3, 4 and 5; LPIN2 and 3) and decrease in the levels of high-density lipoproteins (HDLs; decrease in the activity of LCAT, PPARA, B, C and D; PRKAA1 and 2); this is actually observed in the event of abdominal obesity and metabolic syndrome in children of all ages [20][21][22]. In girls this type of obesity is observed in case of ovarian scleropolycystosis and disturbs menstrual and reproductive functions.…”

Section: Magnesium Deficiency Causes Susceptibility To Arterial Hypermentioning

confidence: 99%

Magnesium Deficit as a Modern Nutritional Issue in Children and Adolescents

Громова¹

2014

Pediatr. farmakol.

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The review is dedicated to the issues of body magnesium deficit. The authors used data of the evidence-based trials. The authors consider pathologic conditions predisposed by magnesium deficit, i.e. excess weight and obesity, attention deficit and hyperactivity disorder, impaired glucose intolerance, arterial hypertension, gallstone disease and other conditions in detail. The authors dwell upon ways of magnesium deficit correction. The article shows that the most effective method is application of organic magnesium salts (lactate, pidolate, citrate).

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“…Our previous study clarified that magnesium (Mg) deficiency increased Mo concentration in the liver of rats [15]. We hypothesized that Mg deficiency disturbs the homeostatic mechanism of Mo and increases hepatic Mo concentration.…”

Section: Introductionmentioning

confidence: 98%

The Effects of Magnesium Deficiency on Molybdenum Metabolism in Rats

Kim

Funaba

Yoshida

et al. 2012

Biol Trace Elem Res

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Our previous report indicated that magnesium (Mg) deficiency increased molybdenum (Mo) concentration in the rat liver, suggesting the possibility that Mg deficiency affects Mo metabolism. Growing male rats were given a control diet or a Mg-deficient diet for 4 weeks. Urine and feces were collected during the second and fourth weeks of the feeding trial. The liver, kidney, spleen, skeletal muscle, and blood were collected at the end of the feeding trial. Mg deficiency did not affect the apparent absorption of Mo, but it reduced urinary excretion of Mo. The retention of Mo tended to be higher in the Mg-deficient group than in the control group. Hepatic Mo concentration was higher in the Mg-deficient group than in the control group, but Mg deficiency did not affect Mo concentration in other tissues and plasma. Mg deficiency downregulated the mRNA expression of Mo transporter 2 (MOT2) in the liver, but not in the kidney. These results suggest that Mg deficiency decreases urinary Mo excretion, which is too slight to affect plasma Mo concentration, and that Mg deficiency selectively disturbs the homeostatic mechanism of Mo in the liver, which is not related to the mRNA expression of MOT2 in the liver.

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Effect of Magnesium Deficiency on Various Mineral Concentrations in Rat Liver

Cited by 10 publications

References 18 publications

Reduction of liver manganese concentration in response to the ingestion of excess zinc: identification using metallomic analyses

Reduction of liver manganese concentration in response to the ingestion of excess zinc: identification using metallomic analyses

Magnesium Deficit as a Modern Nutritional Issue in Children and Adolescents

The Effects of Magnesium Deficiency on Molybdenum Metabolism in Rats

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