Effect of magnesium ion incorporation on the thermal stability, dissolution behavior and bioactivity in Bioglass-derived glasses

Souza, Marina Trevelin; Crovace, Murilo C.; Schröder, Cornelia; Eckert, Hellmut; Peitl, Oscar; Zanotto, Edgar Dutra

doi:10.1016/j.jnoncrysol.2013.10.001

Cited by 59 publications

(44 citation statements)

References 42 publications

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“…As for direct CaP precipitation, many studies have sought to unveil the in vitro HCA formation processes from silicate-based BGs [ 2 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], as well as their relationship to the glass composition and structure [ 2 , 3 , 29 , 40 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Here the glass is typically immersed in an acellular simulated body fluid ( SBF ) solution that matches the concentrations of inorganic species in human plasma [ 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

“…Notably, much of the literature on apatite formation from BGs is overall vague as to the details of this amorphous “CaO–P

-rich film” [ 2 ], whose precise chemical/structural nature is challenging to characterize experimentally. Yet, recent solid-state

P NMR studies [ 36 , 37 , 38 , 39 , 40 , 44 ] of the amorphous portion of the in vitro-formed CaP surface layer (a.k.a. the “CaO–P

-rich film”) reveal very similar NMR parameters with those reported from ACP precipitated from calcium phosphate solutions [ 20 , 21 , 22 , 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…the “CaO–P

-rich film”) reveal very similar NMR parameters with those reported from ACP precipitated from calcium phosphate solutions [ 20 , 21 , 22 , 59 , 60 ]. Notwithstanding that many researchers in the BG community do identify the “CaO–P

-rich film” with “ACP” [ 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 61 ], this salient feature appears not to be widely recognized.…”

Section: Introductionmentioning

confidence: 99%

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Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

2018

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Body-fluid-exposed bioactive glasses (BGs) integrate with living tissues due to the formation of a biomimetic surface layer of calcium hydroxy-carbonate apatite (HCA) with a close composition to bone mineral. Vast efforts have been spent to understand the mechanisms underlying in vitro apatite mineralization, as either formed by direct precipitation from supersaturated solutions, or from BG substrates in a simulated body fluid (SBF). Formally, these two scenarios are distinct and have hitherto been discussed as such. Herein, we contrast them and identify several shared features. We monitored the formation of amorphous calcium phosphate (ACP) and its crystallization into HCA from a Na2O–CaO–SiO2–P2O5 glass exposed to SBF for variable periods out to 28 days. The HCA growth was assessed semi-quantitatively by Fourier transform infrared spectroscopy and powder X-ray diffraction, with the evolution of the relative apatite content for increasing SBF-exposure periods evaluated against trends in Ca and P concentrations in the accompanying solutions. This revealed a sigmoidal apatite growth behavior, well-known to apply to spontaneously precipitated apatite. The results are discussed in relation to the prevailing mechanism proposed for in vitro HCA formation from silicate-based BGs, where we highlight largely simultaneous growth processes of ACP and HCA.

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Section: Introductionmentioning

confidence: 99%

“…Notably, much of the literature on apatite formation from BGs is overall vague as to the details of this amorphous “CaO–P

-rich film” [ 2 ], whose precise chemical/structural nature is challenging to characterize experimentally. Yet, recent solid-state

P NMR studies [ 36 , 37 , 38 , 39 , 40 , 44 ] of the amorphous portion of the in vitro-formed CaP surface layer (a.k.a. the “CaO–P

-rich film”) reveal very similar NMR parameters with those reported from ACP precipitated from calcium phosphate solutions [ 20 , 21 , 22 , 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…the “CaO–P

-rich film” with “ACP” [ 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 61 ], this salient feature appears not to be widely recognized.…”

Section: Introductionmentioning

confidence: 99%

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Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

2018

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“…While both the sol-gel/EISA routes yield porous structures associated with large surface areas, the EISA-derived mesoporous bioactive glasses (MBGs) 5-8 feature ordered mesoporous networks that is believed to accelerate the HCA formation rate, i.e., the "bioactivity" of the material. [18][19][20][21][22][23][24] Such studies are often complemented by measuring the concentrations of Ca, P, and Si in the solution after the SBF-exposure of the (M)BG; this typically reveals an initial elevation of the Ca and P concentrations (stemming from the (M)BG dissolution), followed by their reduction during the subsequent ACP/HCA formation processes. [11][12][13] The "in vitro bioactivity" of a given (M)BG specimen is normally evaluated by monitoring the onset of HCA formation, and qualitatively assessing the amount thereof when the biomaterial is immersed in a simulated body fluid (SBF) for progressively increased intervals.…”

Section: Introductionmentioning

confidence: 99%

Composition-dependent in vitro apatite formation at mesoporous bioactive glass-surfaces quantified by solid-state NMR and powder XRD

et al. 2015

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Silicate-based bioactive glasses exhibit bone-bonding properties due to the formation of a hydroxy-carbonate apatite (HCA) layer at the glass surface on its contact with living tissues.This bone-healing process is triggered by ionic exchange between the glass and the surrounding fluids and thereby depends on the glass composition. In this work, the HCA formation from three mesoporous bioactive glasses (MBGs) of different compositions immersed in a simulated body fluid (SBF) was monitored for variable time intervals between 15 minutes to 30 days. By utilizing two independent assessment techniques, solid-state 31 P NMR spectroscopy and powder X-ray diffraction (PXRD), we report the first quantitative assessment of the HCA growth (i.e., "in vitro bioactivity") from a bioactive glass: both techniques allow for monitoring the crystallization of the amorphous calcium phosphate (ACP) precursor into HCA, i.e., a profile of the relative ACP/HCA fractions of the biomimetic phosphate layer formed at each MBG surface and SBF-exposure period. The amount of HCA present in each solid specimen after the SBF treatment, as well as the composition of the remaining cation-depleted MBG phase, was determined from PXRD data in conjunction with measured concentrations of Ca, Si and P in the solution. In contrast with previous findings from in vitro bioactivity assessments of the same MBG compositions, the HCA formation is herein observed to increase concurrently with the Ca and P contents of the MBG; these apparently different composition-bioactivity observations stem from a significantly lower MBG-loading in the SBF solution utilized herein. The results are discussed in relation to the general task of performing bioactivity testing in SBF, where we highlight the importance of adapting the concentration of the biomaterial to its composition to avoid perturbing the HCA crystallization and thereby altering the outcome of the test.2 An EISA procedure 4 was employed to prepare three MBG specimens of nominal molar compositions 10CaO-90SiO 2 , 10CaO-85SiO 2 -5P 2 O 5 , and 37CaO-58SiO 2 -5P 2 O 5 (see Table 1). Each of Si, P, and Ca was incorporated by using precursors of tetraethyl orthosilicate (TEOS), triethyl phosphate (TEP) and Ca(NO 3 ) 2 ·4H 2 O, respectively. non ionic P123 triblock copolymer as structure-directing agent and other conditions as described in detail in ref. 7 The resulting homogeneous membranes were heated at 700 • C for 6 h to remove organic species and nitrate ions. In Vitro Studies and Composition AnalysesAn SBF solution was prepared according to Kokubo et al. 27 by dissolving NaCl, KCl, NaHCO 3 , K 2 HPO 4 ·3H 2 O, MgCl 2 ·6H 2 O, CaCl 2 , and Na 2 SO 4 into distilled water. It was buffered at pH=7.38 by using tris(hydroxymethyl)-aminomethane/HCl (TRIS/HCl) and subsequently passed through 0.22 µm Millipore filters to avoid bacterial contamination. 600 mg of each pristine MBG sample in the form of a fine powder (<20 µm particles) was immersed in 1.000 L of SBF in a sealed polyethylene container placed in an Ecotron ...

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“…These experiments were performed in pure water, water enriched in elements from the glass (Luckscheiter and Nesovic, 2004;Thien et al, 2012) and in salt solutions (Godon et al, 1988;Abdelouas et al, 1993). The stability and dissolution behavior of bioglass, designed to form chemical bonds with living tissues (Souza et al, 2013), is of interest to the medical field. Glass alteration is also a crucial issue in the field of cultural heritage, especially with respect to the restoration and conservation of stained glass windows (see, for example Silvestri et al, 2005;Warkinson et al, 2005;Cagno et al, 2011;Gentaz, 2011;Schalm et al, 2010;Sterpenich, 2011;Lombardo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Impact of iron chelators on short-term dissolution of basaltic glass

Pérez¹,

Rossano²,

Trcera

et al. 2015

Geochimica et Cosmochimica Acta

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Effect of magnesium ion incorporation on the thermal stability, dissolution behavior and bioactivity in Bioglass-derived glasses

Cited by 59 publications

References 42 publications

Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

Composition-dependent in vitro apatite formation at mesoporous bioactive glass-surfaces quantified by solid-state NMR and powder XRD

Impact of iron chelators on short-term dissolution of basaltic glass

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