Effect of magnesium on plasma cholinesterase activity

Kambam, J. R.; Perry, S. M.; Entman, Stephen S.; Smith, Bradley E.

doi:10.1016/s0002-9378(88)80073-5

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…While others have reported that there is no difference in plasma cholinesterase activity between preeclamptic and normal pregnancy. 15,[20][21][22] The decreased activity of cholinesterase levels in preeclamptic mothers may be attributed to hemodilution and hypoalbuminemia. Preeclampsia induced hepatic dysfunction may be another cause for this decline of cholinesterase activity.…”

Section: Resultsmentioning

confidence: 99%

Cholinesterase Levels in Cord Blood in Preeclamptics

Kharb¹,

Panjeta²,

Vikas³

et al. 2019

JCDR

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Objective: Human placenta, a non-neural tissue, contains cholinergic system and high affinity muscarinic receptors. Role of Cholinesterases (CE) in trophoblast function and pregnancy is not clear. The present study was planned to analyse cholinesterase (CE) levels in cord blood in preeclamptic women. Materials and Methods: Cholinesterase levels were analyzed in maternal and cord blood in women with preeclampsia (n=25) and compared with those of normotensive pregnant women (n=25) and normal, healthy controls (n=25) by kinetic method (new DGKC method) using auto analyzer. Results: Cholinesterase levels were lower in maternal blood of preeclamptics as compared to normotensive controls. Cord blood cholinesterase levels were lowered in babies of normotensives and cord blood CE levels were 88.65% of the maternal levels. Cord cholinesterase levels were significantly lowered in preeclamptic as compared to normotensive pregnant. On comparing CE levels with normal control (Group III) it was observed that CE levels were significantly raised both in normotensive as well as preeclamptic women. Conclusion: Findings of the present study indicate that decrease in cholinesterase levels in preeclampsia via loss of muscarinic cholinergic receptors occurring in preeclampsia.

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Section: Resultsmentioning

confidence: 99%

Cholinesterase Levels in Cord Blood in Preeclamptics

Kharb¹,

Panjeta²,

Vikas³

et al. 2019

JCDR

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“…Further, ChE deficiency adversely affects the response of the patient to certain local anesthetics (e.g., procaine) and general anesthetics (e.g., propanidid) [45,46]. It should be stressed here that BChE decreases in activity during normal pregnancy [14,16] and an added burden is exerted if the patient suffers from PE as manifested by further reductions in the enzyme activity [17,24,[37][38][39]. Such a condition during pregnancy with or without PE has also toxicological implications upon exposure to ChE-inhibiting pesticides [47], as well as therapeutic considerations with neuromuscular blocking agents when needed during cesarean section delivery [13,18].…”

Section: Discussionmentioning

confidence: 98%

“…The reason for the reduced BChE activity is not clear at present. As pregnancy and PE were reported to be associated with oxidative stress and/or reduced BChE activity [14][15][16][17]38], it was suggested that this enzyme is associated with the pathogenesis of PE through complex pathways involving lipid and lipoprotein metabolism and the occurrence of oxidative stress [38]. This condition has also therapeutic considerations with antioxidants, antiChE agents, and anesthetics which could be used during pregnancy complicated with PE [40,[44][45][46].…”

Section: Discussionmentioning

confidence: 99%

“…Figure 1 depicts all the studies screened and then selected for the present meta-analysis according to PRISMA guidelines [28]. Fifteen studies were selected [11,17,23,24,29,[31][32][33][34][35][36][37][38][39][40], comprising 20 records of BChE activity in preeclamptic women in comparison with healthy pregnant controls.…”

Section: Data Extraction and Handlingmentioning

confidence: 99%

“…3.1.1.8), also called butyrylcholinesterase (BChE), is found in the plasma, serum, or whole blood, and it was reported among other blood biochemical determinants such as oxidative stress, to undergo considerable alterations in the last trimester of pregnancy [11,[14][15][16]. Hence, an additional reduction in BChE activity could be a risk factor associated with PE, especially when applying neuromuscular blocking agents in case anesthesia is needed for cesarean section delivery, stressing the fact that several studies have cautioned from the consequences of reduced BChE activity in pregnant women with PE [16][17][18][19][20][21][22]. However, discrepancies have emerged regarding the status of BChE activity in preeclamptic pregnant women.…”

Section: Introductionmentioning

confidence: 99%

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Association of Reduced Maternal Plasma Cholinesterase Activity With Preeclampsia: A Meta-Analysis

Mohammad,

Mohammed,

Garmavy

et al. 2023

Cureus

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Blood butyrylcholinesterase (BChE) activity has been found to decrease during pregnancy and reportedly decrease even more in preeclampsia (PE). The purpose of the present meta-analysis was to answer a specific question of whether BChE activity (in the plasma, serum, or whole blood) is reduced in pregnant women suffering from PE compared to those with normal pregnancy. The meta-analysis included 15 studies with 20 records of BChE activity in 608 women compared to 569 healthy pregnant (control) ones. The studies were subjected to quality assessment using the Newcastle-Ottawa Scale (NOS). Using the Meta-Essentials software program 1.5, the one-group random effects model and forest plot revealed that the percentage of BChE activity in pregnant women with PE was 84.84% of the control value, with a standard error of 4.09 and 95% C.I. of 76.28, 93.41, indicating a significant 15.16% reduction in BChE activity in comparison to healthy pregnancy. No significant heterogeneity was seen in the analyzed data and the funnel plot did show publication bias. Subgroup (mild, severe, and unclassified PE) forest plot analysis revealed that the % BChE activities in PE compared to respective healthy pregnancies were 96.28%, 97.08%, and 76.62%, respectively with no heterogeneity. The median NOS score of the 15 studies included in the meta-analysis was 7, ranging from 5 to 8 (medium to high quality), and the forest plot showed an effect size of 0.735. This meta-analysis shows that BChE activity is reduced in PE compared with normal pregnancy and its value as a biomarker warrants further clinical studies.

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Muscle relaxants during pregnancy and the puerperium

Backus

1995

Seminars in Anesthesia, Perioperative Medicine and Pain

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Effect of magnesium on plasma cholinesterase activity

Cited by 15 publications

References 8 publications

Cholinesterase Levels in Cord Blood in Preeclamptics

Cholinesterase Levels in Cord Blood in Preeclamptics

Association of Reduced Maternal Plasma Cholinesterase Activity With Preeclampsia: A Meta-Analysis

Muscle relaxants during pregnancy and the puerperium

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