Effect of Magnesium on Plasma Cholinesterase Activity

Kambam, J. R.; Perry, S. M.; Entman, Stephen S.; Smith, Bradley E.

doi:10.1097/00132586-198906000-00009

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“…Structurally it is a substituted benzamide, and a derivative of procainamide. Some benzamides, including procainamide, and local anaesthetic agents, have been shown to inhibit plasma cholinesterase in vitro [1][2][3][4][5]. The nature of such inhibition has been reported to be non-competitive in nature [5].…”

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confidence: 99%

The characteristics of the inhibition of serum cholinesterase by metoclopramide

Graham

Crossley

1995

Eur J Clin Pharmacol

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The inhibition of serum cholinesterase by metoclopramide has been previously characterised in vitro at high dilution of the enzyme. We examined the effect of varying enzyme dilution over a range of 1000 fold dilution, and assay temperature at 25 degrees C and 37 degrees C on the fractional inhibition of enzyme activity by metoclopramide. Neither enzyme concentration nor reaction temperature affected this fractional inhibition. Concentrations of metoclopramide producing 50% inhibition of enzyme activity were in the range 1.0-1.9 x 10(-6) M. Lineweaver-Burk analysis of the enzyme reaction suggests that the pattern of this inhibition is competitive.

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confidence: 99%

The characteristics of the inhibition of serum cholinesterase by metoclopramide

Graham

Crossley

1995

Eur J Clin Pharmacol

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“…Data produced by several investigators show that plasma cholinesterase activity declines during normal pregnancy (15)(16)(17), while others have reported that there is no change in plasma cholinesterase activity between preeclamptic and normal pregnancy (13,(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%