Effect of Magnesium Sulfate in Attenuating Arterial Blood Pressure in Elective Laparoscopic Abdominal Surgeries

Abstract

BACKGROUNDA Prospective Randomised Control Trial was done to evaluate the effect of Magnesium Sulfate on haemodynamic parameters in patients undergoing elective laparoscopic abdominal surgeries. MATERIALS AND METHODS80 patients were divided into 2 groups of 40 each. Group A received Magnesium Sulfate 50 mg/kg and Group B received 50 mL Normal Saline. Statistical Analysis used-The statistical difference in age, weight, height of the subjects and haemodynamic parameters such as pulse rate, systolic blood pressure, diastolic blood pressure and sedation were compared. Quantitative data is summarised using mean and standard deviation. The difference in mean between quantitative variable was tested using student's 't' test. RESULTSThe baseline characteristics of the Intervention and Control groups were comparable and there was no significant difference between the groups. Systolic and Diastolic BP were higher in Control group than magnesium group. There was no significant difference in sedation levels in both groups. CONCLUSIONIn our study, we conclude that IV magnesium sulfate, when given before pneumoperitoneum attenuates arterial pressure increase during elective laparoscopic abdominal surgeries. This attenuation is apparently related to reductions in the release of catecholamine, vasopressin or both by magnesium sulfate. We also found that there is no adverse effect of magnesium like sedation or prolonged neuromuscular blockade at the dose we used.