Effect of magnetic nanoparticles coating on their electrochemical behaviour at a polarized liquid/liquid interface

Betancourt, Sara N. Moya; Cámara, Candelaria Inés; Juárez, Ana Valeria; López, Graciela; Riva, Julieta Soledad

doi:10.1016/j.jelechem.2022.116253

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…Additionally, for these figures, the area is given in terms of area per lipid molecule. The complete characterization of these MNPs was previously reported, where the size of both MNP types was shown to be around 12 nm [ 21 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The Fe 3 O 4 @CHI and Fe 3 O 4 @DEAED-D MNPs used in this study are Fe 3 O 4 MNPs with a core diameter of 12 nm and capped with CHI (Sigma Aldrich, low molecular weight) or DEAE-D (CarboMer, Inc. medium molecular weight). These MNPs were synthesized and characterized as previously reported [ 21 ]. Phospholipid DSPAs were purchased from Avanti Polar Lipids (Alabaster, Al).…”

Section: Methodsmentioning

confidence: 99%

“…Among the different MNPs, magnetite Fe 3 O 4 is the most widely proposed for use in biomedicine, as it appears to be the most biocompatible. MNPs are coated with organic materials to increase biocompatibility, prevent aggregation and also to be dispersible in aqueous media [ 20 , 21 , 22 ]. Carbohydrates are good candidates for coating MNPs, since they have been proposed in several articles [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

2023

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Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%