Effect of Malarial Treatments on Biochemical Parameters and Plasma pH of Mice 
 Infected with Plasmodium berghei

Olayemi, SO; Arikawe, AP; K.A, Akinyede; ., A.I. Oreagba; Awodele, Olufunsho

doi:10.3923/ijp.2012.549.554

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…In the current study, the nature of insulin resistance caused by malaria was investigated in type 2 diabetic and non-diabetic Sprague-Dawley rats, as a model for human malaria in type 2 diabetes patients and their non-diabetic counterpart. Compared with naïve uninfected animals, animals infected with P. berghei exhibited higher levels of plasma glucose and HOMAIR but a lower level of HOMAB in line with observations in human studies (2,3) but at variance with other studies in mice and rat which reported a lower level of glucose during P. berghei infection (19,20,21) . The elevated glucose level has been ascribed to increased gluconeogenesis (22) and reduced glucose utilization by uninfected red blood cells (23) , suggesting that circulating glucose level during Plasmodial infection depends on the degree of infection.…”

Section: Discussioncontrasting

confidence: 42%

“…The elevated glucose level has been ascribed to increased gluconeogenesis (22) and reduced glucose utilization by uninfected red blood cells (23) , suggesting that circulating glucose level during Plasmodial infection depends on the degree of infection. However, the difference between the current study and the earlier ones (19,20,21) could stem from differences in the type of the investigated malaria cases. Whereas the observation of reduced glucose level due to P. berghei infection by previous studies (19,20,21) mirrored the situation in severe cases of malaria, the current study is centered on mild malaria cases as normally observed in adult semi-immune human subjects.…”

Section: Discussioncontrasting

confidence: 41%

“…However, the difference between the current study and the earlier ones (19,20,21) could stem from differences in the type of the investigated malaria cases. Whereas the observation of reduced glucose level due to P. berghei infection by previous studies (19,20,21) mirrored the situation in severe cases of malaria, the current study is centered on mild malaria cases as normally observed in adult semi-immune human subjects. Insulin is an important hormone whose activity is critical to the circulating level of blood glucose.…”

Section: Discussioncontrasting

confidence: 41%

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Association of Insulin Resistance with Parasitaemia in Rat Malaria

Acquah

Ameyaw

Derkyi-Kwarteng

et al. 2017

IAM

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Background: Recent evidence implicates malaria as a likely risk factor for the development of type 2 diabetes mellitus (T2DM) through insulin resistance. However, the nature of malaria-induced insulin resistance and its relation to parasitaemia as well as the influence of multiple episodes on insulin resistance are unknown. As a result, the current work was designed to investigate the nature, the extent of infection and effects of episodes of malaria on insulin resistance in adult Sprague-Dawley rats. Methods: One hundred and forty rats were used for the experiments. Rats were grouped into naïve, malaria only, T2DM only and comorbidity of malaria and T2DM groups. Malaria was induced by Plasmodium berghei. Serum glucose and insulin levels were assessed before, during and after P. bergheiinduced malaria. Homeostatic models assessment of insulin resistance (HOMAIR) and beta cell function (HOMAB) were computed. After the first bout of infection, animals were treated and subjected to the second episode of P. berghei infection. Results: Compared to the naïve group, levels of glucose and HOMAIR in the various treatment groups increased (P <0.05) but that of HOMAB decreased during the first episode of P. berghei infection. After treatment, only HOMAIR level was comparable across groups with glucose and HOMAB levels being highest in T2DM only and P. berghei-infected only animals respectively. A similar trend was observed in the second episode of P. berghei infection except that increased HOMAIR was observed at a much lower (P = 0.045) parasitaemia of 6.45% compared to 9.13% in the first episode. Parasitaemia correlated positively with HOMAIR (R = +0.297; P = 0.028) irrespective of episode of infection. Hypoglycemic effect of metformin was attenuated in P. berghei infection. Conclusion: P. berghei infection increased HOMAIR levels in diabetic and non-diabetic rats even at a relatively reduced parasitaemia. This observation may have implications for the evolution of T2DM in malaria-endemic regions.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussioncontrasting

confidence: 41%

Section: Discussioncontrasting

confidence: 41%

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Association of Insulin Resistance with Parasitaemia in Rat Malaria

Acquah

Ameyaw

Derkyi-Kwarteng

et al. 2017

IAM

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“…also suggested a significantly increased lipid treatment peroxidation in pregnant and nonpregnant women with malaria who received treatment for malaria. Other studies also showed a significant reduction in total cholesterol in the brain of Wistar rats on AQ and a greater degree of lipid peroxidation in malaria infected mice on AS/AQ treatment . These changes were attributed to the alteration in enzymatic and nonenzymatic antioxidant defence systems which give rise to increased lipid peroxidation .…”

Section: Discussionmentioning

confidence: 87%

Assessment of the safety of non-fixed-dose combination of artesunate and amodiaquine for uncomplicated falciparum malaria in pregnancy: a nonrandomized open-label study

Iribhogbe

Igue

Odianosen

2017

J Pharm Health Serv Res

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Objectives The objectives of this study were to determine the safety of the use of nonfixed-dose combination of artesunate (AS) and amodiaquine (AQ) in the treatment of uncomplicated falciparum malaria in pregnancy. In this regard, the focus was on the possible effects of the combination on biochemical and haematological parameters as well as other adverse drug reactions associated with the use of the drugs. Methods Ninety subjects were recruited from pregnant women on antenatal care visit to a busy hospital in Esan West Local Government Area, Edo State Nigeria. Fifty met the criteria for the diagnosis of uncomplicated malaria. They were placed on treatment with standard doses of AS 4 mg/kg and AQ 10 mg/kg daily for 3 days. Forty apparently healthy pregnant women and 30 nonpregnant women were used as control. Patients on AS + AQ combination were monitored closely for 28 days. Key findings There was a significant reduction in high-density lipoprotein cholesterol-C: 24.60 AE 1.20 mg/dl) in the test group (P < 0.05) when compared with pregnant control (27.57 AE 0.89 mg/dl) and a nonsignificant reduction (P > 0.05) in low-density lipoprotein cholesterol-C: 83.55 AE 6.10 mg/dl) levels compared with control (87.82 AE 4.88 mg/dl). Additionally, there was a nonsignificant elevation (P > 0.05) of conjugated bilirubin in the test group (0.48 AE 0.06 mg/dl) when compared with pregnant control (0.40 AE 0.04 mg/dl). Changes in haemoglobin concentration (10.45 AE 0.23 g/dl) and packed cell volume (31.37 AE 0.70%) in patients treated with AS + AQ combination were not significant compared with pregnant control (10.18 AE 0.27 g/dl and 31.17 AE 0.55% respectively). Alkaline phosphatase (120.27 AE 7.81 IU/l) was not significantly elevated (P > 0.05) in patients treated with AS + AQ combination compared with pregnant control (117.81 AE 10.61 IU/l). Conclusion We conclude that the use of this combination is safe and well tolerated in pregnant women with uncomplicated falciparum malaria.

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“…Successful chemotherapy depends largely on the ability to exploit metabolic differences between pathogens and the host (Onyesom & Agho, 2011). The malaria parasite has developed resistance to drugs used in the therapy of malaria, except the artemisinins (Olayemi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials

Adisa

Sulaimon

2017

Acta Biochim Pol

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The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection. Six groups of five mice each categorized as healthy control (non-parasitized non-treated group), parasitized-non-treated (PnT), parasitized-chloroquine-treated (positive control), parasitized-Artecxin, -Lonart and -P-Alaxin-treated groups were used for the study. Hepatic antioxidant status was assessed with levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as activity of superoxide dismutase (SOD) and catalase (CAT) in the post mitochondrial and mitochondrial fractions. Mitochondrial membrane integrity was also evaluated with activity of succinate dehydrogenase and levels of phospholipids, cholesterol and proteins in the liver mitochondria. Results revealed that treatment of parasitized mice with the antimalarial drugs significantly (p<0.05) decreased hepatic malondialdehyde (MDA) and mitochondrial membrane phospholipids compared to parasitized untreated group. On the other hand, significantly (p<0.05) elevated succinate dehydrogenase (SDH) activity, mitochondrial membrane cholesterol level, GSH concentration, catalase (CAT) and superoxide dismutase (SOD) activity in the post mitochondrial fraction were obtained. Thus, antimalarial drugs distort mitochondrial membrane integrity and electron transfer but reduce the malaria-induced oxidative stress on the host.

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Effect of Malarial Treatments on Biochemical Parameters and Plasma pH of Mice Infected with Plasmodium berghei

Cited by 12 publications

References 16 publications

Association of Insulin Resistance with Parasitaemia in Rat Malaria

Association of Insulin Resistance with Parasitaemia in Rat Malaria

Assessment of the safety of non-fixed-dose combination of artesunate and amodiaquine for uncomplicated falciparum malaria in pregnancy: a nonrandomized open-label study

Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials

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