Effect of Malnutrition on K<sup>+</sup>Current in T Lymphocytes

Fernández, Rafael Godínez; Leehan, Joaquin Azpiroz; Pastrana, Reyna Fierro; Muñiz, Rocío Ortíz

doi:10.1128/cdli.12.7.808-813.2005

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…However, potassium may have had a pathogenic role. A lower level of potassium may cause abnormal immunity, since activation of the voltage-dependent potassium channel, which is inactivated by hypokalemia, has been shown to have pivotal role in the immune response of T lymphocytes (23).…”

Section: Discussionmentioning

confidence: 99%

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

et al. 2006

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A high plasma aldosterone concentration (PAC) is known to be associated with poor outcome in patients with cardiac disease. However, the prognostic value of PAC in chronic hemodialysis (HD) patients is unknown. In 1996 we examined 128 hypertensive patients treated with antihypertensive drugs, excluding angiotensin-converting enzyme inhibitors, who were undergoing chronic HD (ages 61.8 ± 13.8 years, 62% male), and for whom PAC (ng/dl) data were obtained. We followed up these patients until November 2003.

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Section: Discussionmentioning

confidence: 99%

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

et al. 2006

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“…Previous clinical studies have observed that PD patients with hypokalemia have a high prevalence of peritonitis [ 13 ]. The mechanisms for the increased risk of peritonitis caused by LK is speculated to be associated with malnutrition, impaired immune function and decreased intestinal motility [ 22 ]. Our results confirm that animals fed an LK diet have increased intestinal permeability and occurrence of BT.…”

Section: Discussionmentioning

confidence: 99%

Low potassium disrupt intestinal barrier and result in bacterial translocation

Huang

Fan

et al. 2022

J Transl Med

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Background Bacterial translocation was observed in critical illness and patients with chronic diseases such as liver cirrhosis and chronic kidney disease (CKD). Hypokalemia is a common complication in these diseases. Whether low potassium diet may increase intestinal permeability and result in bacterial translocation lack of evidence. The present study was aimed to investigate the potential effects of LK on intestinal permeability. Methods Grade 8-week-old male Bal B/C mice were randomly placed either on a normal potassium (NK) mouse chow or a low potassium (LK) diet for 28 days. Intestinal permeability and expression of tight junction proteins were compared between the two groups. Results Compared with the NK group, the mice in LK group had significantly lower serum potassium level, increased levels of plasmas endotoxin and plasma d-lactate. The bacterial translocation was higher and in occurred mainly in mesenteric lymph nodes (MLN), liver and spleen. The pathologic change of small intestine was obvious with thinner villus lamina propria, shorter crypt depth and thinner intestinal wall. Slight increases in the expression of proteins and mRNA levels of both claudin-1 and claudin-2 were observed in LK group. Conclusions Low potassium diet could increase intestinal permeability and thereby lead to bacterial translocation, which was suspected to result from impaired intestinal epithelial barrier and biological barrier.

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“…Despite many years of research, the exact mechanisms by which malnutrition affecting lymphocyte percentage and functions are still controversial. However, the diminution in the K + conductance by alteration of K (V) channels in severe malnutrition was proved to be one of the possible mechanisms that inhibit the activation of Tlymphocytes [31]. The decrease in lymphocyte ratio in PEM was proved to be due to reduction of serum leptin level, which inhibits thymocyte apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin levels among malnourished children with and without pneumonia

et al. 2016

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The aim was to evaluate the serum leptin level in children with protein-energy malnutrition (PEM) with and without pneumonia. The study included 60 children; 20 were controls, 20 had PEM without infection and 20 had PEM and pneumonia. They were subjected to nutritional assessments; serum leptin level, haemoglobin concentration, white-blood cell (WBC) count, CD4%, serum albumin, blood glucose, blood urea-nitrogen, and serum ferritin, and chest x-ray. Serum leptin levels were independently associated with pneumonia on multivariate analysis. In addition, serum leptin level and CD4% were significantly lower in the groups with PEM and pneumonia than in the group with PEM without pneumonia (p < 0.001). Low serum leptin levels were associated with pneumonia in children with protein energy malnutrition.

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Effect of Malnutrition on K⁺Current in T Lymphocytes

Cited by 9 publications

References 29 publications

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

Low potassium disrupt intestinal barrier and result in bacterial translocation

Serum leptin levels among malnourished children with and without pneumonia

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Effect of Malnutrition on K+Current in T Lymphocytes

Cited by 9 publications

References 29 publications

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

Plasma Aldosterone in Hypertensive Patients on Chronic Hemodialysis: Distribution, Determinants and Impact on Survival

Low potassium disrupt intestinal barrier and result in bacterial translocation

Serum leptin levels among malnourished children with and without pneumonia

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Effect of Malnutrition on K⁺Current in T Lymphocytes