Effect of mancozeb on ovarian compensatory hypertrophy and biochemical constituents in hemicastrated albino rat⋆

Mahadevaswami, M.P.; Jadaramkunti, Umadevi C.; Hiremath, Murigendra B; Kaliwal, B.B.

doi:10.1016/s0890-6238(00)00064-2

Cited by 50 publications

(26 citation statements)

References 32 publications

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“…Proteins are the building blocks, carbohydrates are the immediate source of energy and lipids are reservoirs of energy. The data obtained in the present study has revealed that the levels of protein in the ovary and uterus was significantly decreased Recently similar results have been reported that the levels of protein in ovary and uterus decreases with mancozeb treatment in hemicastrated albino rats 38) . The acute treatment with monocrotophos showed tissue specific inhibition of microsomal Cyt P-450 in hepatic and extra hepatic tissues resulted in the loss of haemoprotein in rats 39) .…”

Section: Discussionsupporting

confidence: 90%

Induction of Gonadal Toxicity to Female Rats after Chronic Exposure to Mancozeb.

Baligar

Kaliwal

2001

INDUSTRIAL HEALTH

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Mancozeb, a fungicide of ethylenebisdithiocarbamate group was orally administered at doses of 500, 600, 700 and 800 mg/kg body weight/day to normal virgin rats of Wistar strain for 30 days. The vaginal smear and body weight of the rats were recorded daily and rats were sacrificed on 31st day. Estrous cycle was effected by showing a significant decrease in the number of estrous cycle, duration of proestrus, estrus and metestrus with concomitant significant increase in the duration of diestrus in all the mancozeb treated groups when compared with controls. There were a significant decrease in the number of healthy follicles and a significant increase in the number of atretic follicles in all the mancozeb treated groups when compared with controls. The histologic observation of the ovary revealed the presence of less number of corpora lutea and the size of the ovary was also reduced in high doses of mancozeb treated rats. There was a significant increase in the thyroid weight in all the mancozeb treated rats except in 500 mg/kg/d. In rats treated with 500 mg/kg/d showed a significant increase in the level of total lipids in the liver. In rats treated with 600 mg/kg/d mancozeb showed a significant decrease in the levels of glycogen and total lipids in the uterus and total lipids in the liver. In rats treated with 700 mg/kg/d showed a significant decrease in the levels of protein in ovary, glycogen, total lipids, phospholipids and neutral lipids in the uterus and a significant increase in the levels of phospholipids, neutral lipids in the ovary and total lipids, phospholipids and neutral lipids in the liver. In rats treated with 800 mg/kg/d showed a significant decrease in the levels of protein and glycogen in the ovary and protein , glycogen, total lipids, phospholipids and neutral lipids in the uterus and a significant increase in the levels of total lipids, phospholipids and neutral lipids in the ovary and liver when compared with controls. These observed effect of mancozeb on the estrous cycle, follicles and biochemical constituents may be due to imbalance in the hormone or toxic effect.

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Section: Discussionsupporting

confidence: 90%

Induction of Gonadal Toxicity to Female Rats after Chronic Exposure to Mancozeb.

Baligar

Kaliwal

2001

INDUSTRIAL HEALTH

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“…Diestrus index was also increased dose dependently in all the groups following the administration of carbofuran. Recently, similar results have been reported that the rats treated with a carbamate fungicide mancozeb causes a significant decrease in the number of estrous cycle and the duration of proestrus, estrus, and metestrus with a concomitant significant increase in diestrus phase 7,19) . Similar results have also been reported with other organophosphate pesticides treated animals [20][21][22][23][24][25] .…”

Section: Discussionsupporting

confidence: 77%

Reproductive Toxicity of Carbofuran to the Female Mice: Effects on Estrous Cycle and Follicles.

Baligar

Kaliwal

2002

INDUSTRIAL HEALTH

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“…Collectively, the decrease in the erythrocyte count and haemoglobin content recorded in the present work indicated that metalaxyl-treated mice were anaemic. According to [19], this anaemia is due to (a) increased blood as a result of the accelerated red cell destruction by haemolytic agents or rapid cell removal from an abnormality of cell shape or over-activity of the spleen (b) a quantitative decrease in blood formation as a result of a quantitative decrease in red marrow from aplasia or a quantitative decrease in marrow activity from a deficiency in the substances necessary for normal bone marrow activity. The results in figures 1 and 2 revealed that total proteins and albumin decreased in metalaxyl-treated animals.…”

Section: Resultsmentioning

confidence: 99%

Haematological and Biochemical Effects of Metalaxyl Fungicide on Albino Mice

Al-Amoudi¹

2012

AJB

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Metalaxyl is a benzenoid fungicide used to control fungal diseases. The aim of this work is to investigate the effect of metalaxyl on haematological and biochemical parameters in male albino mice. In this study, animals were divided into two groups. The animals in the first group (20 mice) were given metalaxyl orally through a stomach tube at a dosage of 1/10 of the LD50 (which was equivalent to 130 mg/kg body weight) at a rate of three times per week for 4 continuous weeks. The second group was treated as a control in which the animals (20 mice) were given water orally. Treating mice with metalaxyl for 2 and 4 weeks induced a significant decrease in the RBC count (5.2±0.24), haemoglobin content (11.5±2.3) and the number of blood platelets (543±15.3). In contrast, metalaxyl treatment induced a significant increase in the WBC count (5.8±0.4). Serum triglyceride and cholesterol levels also increased while total protein and albumin levels decreased in the treated animals. Additionally, metalaxyl treatment resulted in a significant increase in the levels of transaminases, ALT and AST enzymes. The data also revealed a significant increase in serum creatinine in response to metalaxyl toxicity, which might be due to impaired kidney function resulting from fungicide exposure. It was concluded that these metalaxyl effects could be attributed to fungicide-induced oxidative stress, which in turn leads to signs of toxicity. This result was confirmed by other authors who obtained similar results by observing the effects of some fungicides. The premise of this study was that fungicides must be examined for their possible adverse effects on animals and humans before their application to agricultural fields.

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Effect of mancozeb on ovarian compensatory hypertrophy and biochemical constituents in hemicastrated albino rat⋆

Cited by 50 publications

References 32 publications

Induction of Gonadal Toxicity to Female Rats after Chronic Exposure to Mancozeb.

Induction of Gonadal Toxicity to Female Rats after Chronic Exposure to Mancozeb.

Reproductive Toxicity of Carbofuran to the Female Mice: Effects on Estrous Cycle and Follicles.

Haematological and Biochemical Effects of Metalaxyl Fungicide on Albino Mice

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