Effect of Manganese Exposure on MPTP Neurotoxicities

Baek, Sun‐Yong; Lee, Myong-Jong; Jung, Hyun-Sil; Kim, Hyun-Ju; Lee, Choong-Ryeol; Yoo, Cheol-In; Lee, Ji Ho; Lee, Hun; Yoon, Chung Sik; Kim, Young Hoon; Park, Jungsun; Kim, Jae-Woo; Jeon, Beom S.; Kim, Yangho

doi:10.1016/s0161-813x(03)00033-0

Cited by 31 publications

(37 citation statements)

References 28 publications

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“…The present findings were compatible with some human pathologic findings [19][20][21][22][23] , animal pathologic finding 24) , and animal biochemical findings 25,26) . The present finding was also in accordance with our recent brain MRI studies on humans showing that Mn frequently deposits in midbrain as well as globus pallidus 27,28) and the hypertrophy of astrocytes by Mn intoxication in mouse brain finally 7) . However, the present findings do not necessarily mean that Mn also damage dopaminergic pathway.…”

Section: Discussionsupporting

confidence: 93%

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cDNA Array Analysis of Gene Expression Profiles in Brain of Mice Exposed to Manganese

Baek¹,

Cho²,

Kim³

et al. 2004

INDUSTRIAL HEALTH

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This study is performed to detect changes of gene expression in substantia nigra (SN) and striatum in manganese (Mn)-exposed mice brain. The cDNA array is a recently developed molecular biological method that can detect the differential expression of several hundreds of genes simultaneously and is therefore advantageous in the study of trace metal intoxication effect at the genetic level. Using this technology, we discovered 5 genes in the mouse striatum and 9 genes in SN changed by more than 50% following Mn exposure. Depression were observed in two genes (neural cell adhesion protein BIG2, heavy neurofilament subunit genes) in striatum and three genes (light neurofilament subunit, brain acyl-CoA synthetase II, heavy neurofilament subunit genes) in the SN. However three genes (N-acetylglucosaminyltransferase I, S100β β β β β, and synaptonemal complex protein I genes) in striatum and six genes (noggin, striatin, Ost oncogene, S100β β β β β, calcium/calmodulindependent protein kinase kinase beta, and N-acetylglucosaminyltransferase I genes) in SN were elevated following Mn exposure. Immunohistochemical study revealed that protein levels of S100β β β β β also increased following Mn treatment. Activated astrocytes overexpressing S100β β β β β are invariably and intimately associated with decreased expression of heavy and light neurofilament subunits which is a distinguishing feature of neurodegeneration by Mn exposure. All our findings suggested that neuronal degenerations occur in SN as well as striatum of mice exposed to Mn.

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Section: Discussionsupporting

confidence: 93%

“…These experiments were carried out using a previously reported regimen of Mn exposure 7) . Male C57BL/6 mice (10 wk old, body weight 25-30 g) were caged in an airconditioned room maintained at 22 ± 2°C, relative humidity 50 ± 10%, with a 12/12 h light/dark cycle.…”

Section: Animalsmentioning

confidence: 99%

cDNA Array Analysis of Gene Expression Profiles in Brain of Mice Exposed to Manganese

Baek¹,

Cho²,

Kim³

et al. 2004

INDUSTRIAL HEALTH

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“…Mn has been shown to primarily target the nigrostriatal system, including the globus pallidus and substantia nigra (Baek et al, 2003). Mn exposure varies from moderate, as occurs via drinking water and food sources, to high level exposure from occupational and industrial settings such as mining, welding, and steel manufacturing (Woolf et al, 2002;Roth and Garrick, 2003;Dobson et al, 2004;Olanow, 2004).…”

Section: Discussionmentioning

confidence: 99%

Protein Kinase Cδ Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells

Latchoumycandane¹,

Anantharam²,

Kitazawa³

et al. 2005

The Journal of Pharmacology and Experimental Therapeutics

153

170

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“…However, excessive Mn is also toxic to the brain and can produce an irreversible syndrome resembling Parkinson's disease (Donaldson 1987;Baek et al 2003Baek et al , 2004Olanow 2006). This neurologic syndrome, known as "manganism" (Latchoumycandane et al 2005;Wasserman et al 2006) is thus characterized by a Parkinson-like condition with weakness, anorexia, apathy, slowed speech, emotionless facial expression, and slow movement of the limbs.…”

Section: Inorganic Nutrientsmentioning

confidence: 99%

Assessment of dry season surface, ground, and treated water quality in the Cape Coast municipality of Ghana

Quagraine

Adokoh

2009

Environ Monit Assess

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This aim of this monitoring was to assess water quality in a dry season for the Cape Coast municipality in Ghana, which has been experiencing chronic water shortages. Fifteen different sampling stations--four surface, five ground, and six tap water samples--were analyzed for physicochemical and microbiological parameters during January to April 2005. Levels or trends in water quality that may be deleterious to sensitive water uses, including drinking, irrigation, and livestock watering have been noted with reference to well-established guidelines. Exceedances to some health-based drinking water guidelines included positive coliform for various water samples; pH for all groundwater samples (pH 5.9+/-0.3); conductivity for 50% groundwater; color for about a third of groundwater and tap water; Mn for 44% tap water, 67% groundwater, and 50% surface water samples. The World Health Organization laundry staining Fe guideline of 0.3 mg/l was exceeded by 75% of surface water, 44% tap water, and 53% groundwater samples. The corresponding Mn guideline of 0.1 mg/l was exceeded by all the water samples. Respectively, all surface water samples and also 75% of the surface water exceeded some known Cu and Zn guideline for the protection of aquatic life. Compared to some historic data for Fosu Lagoon, the current study shows a lowering of approximately 1 pH unit, increase of approximately 65% NH3, one to two orders of magnitude increase in PO4(3-), and more than two orders of magnitude increase in NO3-. In several instances, tap water samples collected at the consumers' end of the distribution system did not reflect on the true quality of the treated water. Mn, SO4(2-), PO4(3-), Cu, and Zn were among the chemical contaminations observed to occur in the distribution system.

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Effect of Manganese Exposure on MPTP Neurotoxicities

Cited by 31 publications

References 28 publications

cDNA Array Analysis of Gene Expression Profiles in Brain of Mice Exposed to Manganese

cDNA Array Analysis of Gene Expression Profiles in Brain of Mice Exposed to Manganese

Protein Kinase Cδ Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells

Assessment of dry season surface, ground, and treated water quality in the Cape Coast municipality of Ghana

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