Effect of Manganese Exposure on the Reproductive Organs in Immature Female Rats

Kim, Soo In; Jang, Yeon Seok; Han, Seung Hee; Choi, Myeong Jin; Go, Eun Hye; Cheon, Yong-Pil; Lee, Jung Sick; Lee, Sungho

doi:10.12717/dr.2012.16.4.295

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…The impact of Mn on women’s reproductive health has been investigated in relation to pubertal development in prior work. Specifically, in animal studies using prepubertal female rats, a significant increase in serum LH levels was detected upon MnCl 2 treatment (17, 38) . Given that Mn is abundant in easily obtainable foods (e.g., teas, nuts, legumes, and whole grains), further investigation into the particular sources of dietary Mn and improved ovulatory function could be beneficial for reproductive age women.…”

Section: Discussionmentioning

confidence: 99%

Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

et al. 2018

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Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed up 259 regularly menstruating women aged 18-44 years who were not taking mineral supplements for two menstrual cycles. Intakes of ten selected minerals were assessed through 24-h dietary recalls at up to four times per cycle in each participant. Oestradiol, progesterone, luteinising hormone (LH), follicle-stimulating hormone (FSH), sex-hormone-binding globulin and testosterone were measured in serum up to eight times per cycle. We used weighted linear mixed models to evaluate associations between minerals and hormones and generalised linear models for risk of anovulation. Compared with Na intake ≥1500 mg, Na intake <1500 mg was associated with higher levels of FSH (21·3 %; 95 % CI 7·5, 36·9) and LH (36·8 %; 95 % CI 16·5, 60·5) and lower levels of progesterone (-36·9 %; 95 % CI -56·5, -8·5). Na intake <1500 mg (risk ratio (RR) 2·70; 95 % CI 1·00, 7·31) and Mn intake <1·8 mg (RR 2·00; 95 % CI 1·02, 3·94) were associated with an increased risk of anovulation, compared with higher intakes, respectively. Other measured dietary minerals were not associated with ovulatory function. As essential minerals are mostly obtained via diet, our results comparing insufficient levels with sufficient levels highlight the need for future research on dietary nutrients and their associations with ovulatory cycles.

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Section: Discussionmentioning

confidence: 99%

Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

et al. 2018

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“…Reproductive toxicity of high levels of Mn has been described in some animal experiments (Kim et al, 2012; Liu et al, 2013; Migliaccio et al, 2015). Nevertheless, few human studies summarized the relationship between Mn exposure and male reproductive hormones.…”

Section: Introductionmentioning

confidence: 99%

Occupational manganese exposure, reproductive hormones, and semen quality in male workers: A cross-sectional study

et al. 2018

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It has been found that exposure to manganese (Mn) could induce reproductive dysfunction, but its occupational risk in male workers is unclear. This study aims to assess the association of occupational Mn exposure with reproductive hormones and semen quality in a cross-sectional study. Urinary Mn, semen quality, and reproductive hormones were explored in 84 male workers occupationally exposed to Mn and 92 referents. Multiple linear regression analyses were used to assess the relationship. Urinary Mn levels in Mn-exposed workers ranged from 0.56 to 34.25 µg/L, and the average level was 15.92 ± 8.49 µg/L. Compared with the control group, gonadotropin-releasing hormone (GnRH) levels and luteinizing hormone (LH) levels increased significantly and the levels of testosterone (TSTO) decreased significantly in the Mn-exposed group. There was a significant positive linear association between urinary Mn and GnRH and LH, while the linear association between urinary Mn and TSTO was negative. Sperm progressive motility and total motility decreased significantly in the Mn-exposed group. There was a significantly negative linear association between urinary Mn and sperm progressive motility and total motility. In conclusion, occupational Mn exposure was inversely associated with reproductive health of male workers, resulting in the abnormality of hormones secretion and decrease of sperm motility.

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“…However, excessive exposure to it, besides causing negative impacts on the central nervous system (CNS), can still cause respiratory and reproductive problems [ 6 ]. It is known that exposure to this element is related to significant damage to growth and the reproductive system in studies with rats [ 7 , 8 , 9 ], suggesting that Mn plays a critical role in these processes. Mn stimulates the auto-oxidation of dopamine in dopaminergic neurons [ 10 ], which, in turn, is able to modulate prolactin concentrations (PRL) in the body, since it is an inhibitory regulator of this hormone [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant

Santos

Rodrigues

Bandeira

et al. 2022

IJERPH

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Manganese (Mn) and lead (Pb) have been associated with the deregulation of the neuroendocrine system, which could potentially favor the appearance of precocious puberty (PP) in environmentally exposed children. This study aims to evaluate the exposure to Mn and Pb and their potential effects in anticipating puberty in school-aged children living near a ferromanganese alloy plant in Bahia, Brazil. Toenail, occipital hair and blood samples were collected from 225 school-aged children. Tanner’s scale was used for pubertal staging. Mn in blood (MnB), toenail (MnTn) and hair (MnH) and blood lead (PbB) levels were measured by graphite furnace atomic absorption spectrometry. Puberty-related hormone concentrations were determined by chemiluminescence. The age at which girls’ breasts began to develop was inversely correlated with weight-for-age, height-for-age and BMI-for-age Z-scores (p < 0.05); pubarche also had similar results. Mn biomarker levels did not present differences among pubertal classification nor among children with potential PP or not. Furthermore, Mn exposure was not associated with the age of onset of sexual characteristics for either girls or boys. However, PbB levels were positively correlated with boys’ pubic hair stages (rho = 0.258; p = 0.009) and associated with the age of onset of girls’ pubarche (β = 0.299, 95%CI = 0.055–0.542; p = 0.017). Testosterone and LH concentrations were statistically higher in boys with an increased PbB (p = 0.09 and p = 0.02, respectively). Prospective studies are needed to better assess the association between exposure to Mn and Pb and the early onset of puberty.

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Effect of Manganese Exposure on the Reproductive Organs in Immature Female Rats

Cited by 13 publications

References 15 publications

Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

Occupational manganese exposure, reproductive hormones, and semen quality in male workers: A cross-sectional study

Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant

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