Effect of manganese on neural endocrine hormones in serum of welders and smelters

Ou, Shi Yan; Luo, Hai Lan; Mailman, Richard B.; Zhang, Yu Wen; Mei, Cai; Huang, Xiao; Li, Shao Jun; Jiang, Yue

doi:10.1016/j.jtemb.2018.05.018

Cited by 17 publications

(8 citation statements)

References 56 publications

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“…Furthermore, low serum T4 and T3 levels have also been shown to be correlated with reproductive disorders [47]. It is worth noting that excessive metals exposure may adversely affect normal CNS development and the reproductive system via destroying the balance of thyroid hormones system, including Mn [15,48]. For example, an early study showed that Mn chloride (10 and 20 mg/kg) treatment for 24 hours markedly decreased thyroid hormone levels in serum, the percentages of iodinated thyronines, and the protein-bound iodide fraction in the thyroids of rats [49], which was confirmed by a subsequent study [50].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Hoseini et al [51] showed that Mn treatment increased the serum T3 and T4 levels, but has no effects on the thyroid T3 and T4 levels. Additionally, an epidemiologic study on occupational Mn-exposed workers demonstrated that excessive Mn exposure caused an imbalance in the thyroid hormones via decreasing the serum thyroid-stimulating hormone (TSH), testosterone (TST), prolactin (PRL), and follicle-stimulating hormone (FSH) concentrations [15]. The present study showed that Mn chloride treatment for 4 weeks interfered on the balance of thyroid hormones, as indicated by a decrease in the serum T4 and T3 levels, although the serum T3 and T4 levels showed a similar pattern in the present study, as T3 and T4 were decreased in all treatment groups (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…Further, other researchers reported that Mn treatment for 30, 60, and 90 days decreased the T3 and T4 levels in the serum of cocks but induced no changes in serum TSH levels [14]. Additionally, an epidemiology study reported that there was a negative relationship between the elevated Mn levels and thyroid hormone levels in serum [15]. Similarly, studies from other labs found that environmental exposure to high airborne Mn levels induced hypothyroidism in residents via decreasing serum thyroid hormone levels, including T3 and T4 [16].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Chen

Sun

et al. 2019

IJERPH

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Excessive manganese (Mn) exposure may adversely affect the central nervous system, and cause an extrapyramidal disorder known as manganism. The glutamine (Gln)/glutamate (Glu)–γ-aminobutyric acid (GABA) cycle and thyroid hormone system may be involved in Mn-induced neurotoxicity. However, the effect of Mn on the Gln/Glu–GABA cycle in the serum has not been reported. Herein, the present study aimed to investigate the effects of sub-acute Mn exposure on the Gln/Glu–GABA cycle and thyroid hormones levels in the serum of rats, as well as their relationship. The results showed that sub-acute Mn exposure increased serum Mn levels with a correlation coefficient of 0.733. Furthermore, interruption of the Glu/Gln–GABA cycle in serum was found in Mn-exposed rats, as well as thyroid hormone disorder in the serum via increasing serum Glu levels, and decreasing serum Gln, GABA, triiodothyronine (T3) and thyroxine (T4) levels. Additionally, results of partial correlation showed that there was a close relationship between serum Mn levels and the detected indicators accompanied with a positive association between GABA and T3 levels, as well as Gln and T4 levels in the serum of Mn-exposed rats. Unexpectedly, there was no significant correlation between serum Glu and the serum T3 and T4 levels. In conclusion, the results demonstrated that both the Glu/Gln–GABA cycle and thyroid hormone system in the serum may play a potential role in Mn-induced neurotoxicity in rats. Thyroid hormone levels, T3 and T4, have a closer relationship with GABA and Gln levels, respectively, in the serum of rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Chen

Sun

et al. 2019

IJERPH

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“…Despite signifi cant clinical similarities between manganism and Idiopathic Parkinson's Disease (IPD), cumulative evidence shows that manganism primarily affects the globus pallidus and striatum of basal ganglia, whereas IPD mainly targets the substantia nigra [22]. Additionally, some studies have reported a link between occupational exposure to Mn and disorders of seminal functioning and hormone secretion [23,24]. Lead (Pb), a toxic metal with no identifi ed biological function, has been the cause of widespread occupational and environmental contamination and therefore, lead exposure has become a major public health issue.…”

mentioning

confidence: 99%

Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers

Öztan¹,

Türksoy²,

Daltaban³

et al. 2019

Int J Immunother Cancer Res

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Constitutive neurogenesis affects both children and adults and is known to correlate closely with neurocognitive functions such as learning and memory [1]. Infl ammation is a systemic reaction. However, the brain reacts to infl ammation differently than peripheral tissues. Under normal conditions, the Blood-Brain Barrier (BBB) is selectively permeable and allows only the passage of T-cells, macrophages, and dendritic cells [2]. However, infl ammation of the brain initiates the secretion of anti-and pro-infl ammatory cytokines by resident microglia, astrocytes, infi ltrating peripheral macrophages, and lymphocytes. This activity both stimulates the migration of leukocytes to the region and promotes astrogliosis [3]. Pathologically, Parkinson's Disease (PD) is characterized by the massive degeneration and loss of nigrostriatal dopaminergic neurons. Many studies of PD have also emphasized the

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“…One reason for that might be the use of oral contraceptives that increase oxidative stress and CRP levels compared to naturally cycling women, which might have implications even on workload [14]. In addition, metalworkers were associated with adverse neurobehavioral effects right up to the disruption of the endocrine system, such as low testosterone and follicle-stimulating hormone levels upon high-levels of manganese [15].…”

Section: Introductionmentioning

confidence: 99%

Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers

et al. 2022

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Physical workload adversely impacts inflammation, oxidative stress and mood in heavy workers. We compared these risk parameters between metalworkers (n = 20) and office workers (n = 30), including gender differences. Blood samples were analyzed with thirty parameters to overview endocrinology, inflammation, and psychological and oxidative stress. Despite an adequate antioxidative supply, oxidative stress occurred in metalworkers, as indicated by significantly increased peroxide and homocysteine (Hcy) levels. Moreover, increased concentrations were observed in this group regarding psychological stress and diet-related parameters. Sex-specific differences were determined for physical dimensions, dehydroepiandrosterone sulfate (DHEAS), Hcy, uric acid, triglycerides, osmolality, anti-Mullerian hormone (AMH) and testosterone. Age-associated differences were observed for DHEAS, glycosylated hemoglobin, adrenaline, AMH and testosterone. In male office workers, the body mass index was associated with increased LDL-HDL, cholesterol-HDL and homeostatic model assessment of insulin resistance (HOMA-IR). In conclusion, these results indicate increased oxidative stress and psychological stress in heavy workers independently of adequate antioxidant sustenance. The sedentary occupation of office workers, in turn, favored diseases of affluence. This might be particularly relevant for long-term occupied persons and older workers due to a hormonal shift coming along, given the risk for oxidative stress-related diseases such as cardiovascular disease, particularly in the case of males, based on their lifestyle habits.

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Effect of manganese on neural endocrine hormones in serum of welders and smelters

Cited by 17 publications

References 56 publications

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers

Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers

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