Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling

Carvalho, Roney Rick; Pellizzon, Cláudia Helena; Justulin, Luis Antônio; Felisbino, Sérgio Luís; Vilegas, Wagner; Bruni, Fernanda Miriane; Lopes-Ferreira, Mônica; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.cbi.2008.10.041

Cited by 43 publications

(34 citation statements)

References 41 publications

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“…The increased MMP-9 expression indicated the increase in the capacity of degradation of extracellular matrix and basement membrane components and further promotion of the tumor cell metastasis [7]. In addition, in the late-stage process of tumor metastasis, MMP-9 could induce tumor angiogenesis [8]. Thus, MMP-9 was closely related to the tumor cell metastasis, and its expression level was positively correlated with malignant degree and metastasis ability of tumor cells [9].…”

Section: Discussionmentioning

confidence: 96%

Influence of lymphatic endothelial cells on proliferation and invasiveness of esophageal carcinoma cells in vitro and lymphangiogenesis in vivo

Nana

Sun

et al. 2015

Med Oncol

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The aim of the study was to investigate the interaction between esophageal carcinoma cells with different differentiation degree and esophageal carcinoma-related lymphatic endothelial cells. Different lymphatic endothelial cell conditioned mediums were used to cultivate well-differentiated esophageal carcinoma EC9706 cells and poorly differentiated esophageal carcinoma KYSE150 cells, and immunocytochemistry and Western blot analyses were applied to detect the expression of MMP-9 protein and TIMP-2 protein in each group; in situ hybridization and RT-PCR methods were used to detect the expression of MMP-9 and TIMP-2 mRNA in each group; CCK-8 method was used to detect cell proliferation in each group; and transwell method was utilized to detect cell invasiveness in each group. Through constructing the transplanted tumor model of esophageal carcinoma of nude mice, the D2-40 and LYVE-1 immunohistochemical staining was performed on transplanted tumors and surrounding tissues, lymphatic microvessels were marked, and lymphatic microvessel density (LMVD) was measured. The expression of MMP-9 protein and mRNA in experimental group was significantly higher than that in control groups (P < 0.05); TIMP-2 protein and mRNA expression in experimental group was significantly lower than that in control groups (P < 0.05); cell proliferation ability and invasiveness ability in experimental group were significantly higher than those in control groups (P < 0.05); LMVD-marked D2-40 and LMVD-marked LYVE-1 of transplanted tumor tissue in the experimental group were significantly higher than those in control groups (P < 0.05). The esophageal squamous carcinoma-related lymphatic microvessel could promote the proliferation and invasive ability of esophageal squamous carcinoma cells in vitro. It had different effects on esophageal carcinoma cells with different differentiation degree and had more obvious influence on poorly differentiated esophageal carcinoma cells, which may be related to the up-regulated MMP-2 expression and down-regulated TIMP-2 expression of esophageal carcinoma cells. The esophageal squamous carcinoma-related lymphatic microvessel endothelial cells could promote the growth of esophageal carcinoma-transplanted tumor of nude mice and lymphangiogenesis.

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Section: Discussionmentioning

confidence: 96%

Influence of lymphatic endothelial cells on proliferation and invasiveness of esophageal carcinoma cells in vitro and lymphangiogenesis in vivo

Nana

Sun

et al. 2015

Med Oncol

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“…Quercetin has been shown to have antioxidant, antimicrobial, antitumor, antihypertensive, antiatherosclerosis and antiinflammatory effects. Mangiferin has antioxidant, antitumor, immunomodulatory, antiinflammatory and antiviral effects (Guha et al, 1996;Lai et al, 2003;Sarkar et al, 2004;Dar et al, 2005;Carvalho et al, 2009;Noratto et al, 2010;Hiraganahalli et al, 2012). Mangiferin also exhibits antidiabetic properties (Muruganandan et al, 2005, Daud et al, 2010Kumar et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Exploration of Mango Fruits (Mangifera indica) as α-Glucosidase Inhibitors

et al. 2017

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Mango fruit (Mangifera indica L.) is the tropical fruit that grows easily in Indonesia with plenty varieties. This study aimed to determine the varieties of mango fruit and the most potent part of mango as antidiabetic agent through α-glucosidase inhibitory activities. Four types of mango fruit (indramayu, manalagi, harum manis, and budiraja) were used in this study. Each part of the mango fruit:peel, flesh, endosperm, and endocarp were extracted by maceration process with three different solvents (n-hexane, ethyl acetate (EtOAc), and ethanol (EtOH)). An ability of all 46 extracts in inhibiting the α-glucosidase at a concentration of 500 ppm were determined. Then 11 extracts with the high inhibition value were determined their IC50 (concentration to inhibit 50% activity) values. EtOAc extract of manalagi, indramayu, and budi raja endosperm had the lowest IC50 value which was not statistically significantly different (at 95%) with EtOAc extract of budi raja peel. The bioautographic Thin Layer Chromatogram showed that the most active band is characterized by white luminescence under UV 366 nm, yellow color under UV 254 and visible light. The band with Rf 0.93 from EtOAc endosperm extract of indramayu and manalagi and Rf 0.73 from EtOAc budi raja peel extract are the most active band which predicted as a flavonoid. The result adds the value of the peel and seed of mango, as well as an alternative in blood sugar control, which is easy to obtain, relatively cheap, and liked by the community. used were different. Cahyanto (2017) has conducted a study of characterization of mango characteristics based on peel anatomy and morphology in Subang, Indonesia against 21 mango varieties that showed different results for each variety. Differences in morphology and anatomy of each mango fruit varieties are expected to be associated with the active component compound content. Therefore, this study aimed to determine the varieties, namely manalagi, harum manis, budi raja, and indramayu and parts of the most potent mangoes as antidiabetic agent through inhibiting the activity of the α-glucosidase enzyme. The result of this study can add the value of all parts of the mango, especially the peel and seed, as well as an alternative in blood sugar control, which is easy to obtain, relatively cheap, and was liked by the community. In addition, the results of this study can be a reference for further research related to antidiabetic activity on mango fruit. How to Cite METHODSFour varieties of mango fruit (manalagi, harum manis, budi raja, and indramayu) were used in this research. All sample were determined in LIPI Cibinong. Each mango fruit was separated into four parts (peels, flesh, endocarp, and endosperm), then dried to dry perfectly at 60 ° C in the oven. After perfectly dried, all sample were grinded into powder.All sample were extracted by maceration methods ranging from n-hexane, EtOAc, and EtOH. The extraction was performed with a sample and solvent ratio of 1: 5 and 1:10 adjusted to the sample condition. The extract ob...

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“…Similarly, beneficial effect has been also reported for different polyphenols [80][81][82][83][84]87 , as well as CoQ 99 but they only have been tested in animals, although for many their in vivo antioxidant effects seems due to iNOS expression or activity modulation and not to free radical scavenging. Unfortunately, at the moment, experimental interventions in humans have been reduced to vitamin C 54-57 but also for E 76 or Zinc 78 , where vitamin E have result the most interesting although it were used after mechanical treatment.…”

Section: Coenzyme Qmentioning

confidence: 99%

“…The additon of several specific polyphenols to the diet have been tested in rodents models of periodontitis. In rat models of ligatureinduced periodontitis oral administration of resveratrol (trans-3,4ʹ,-5-trihydroxystilbene) 80,81 , mangiferin (C2-b-dglucopyranosyl-1,3,6,7-tetrahydroxyxanthone) 82 , baicalin (7-glucuronic acid, 5,6-dihydroxy-flavone) 83 , verbascoside (4,5-hydroxyphenylethanol bound to a b-(d)-glucopyranoside) and quercetin (3,5,7,3ʹ,4ʹ-pentahydroxyflavone) 84 have…”

Section: Polyphenolsmentioning

confidence: 99%

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

et al. 2015

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LICENSE 3.0 UNPORTED. RESUMENObjetivos. Dada la relación existente entre periodontitis crónica y altos niveles de estrés oxidativo, esta revisión pretende clarificar qué papel puede desempeñar la ingesta de los diferentes antioxidantes de la dieta en el mantenimiento de un periodonto saludable y en la reducción del riesgo de padecer periodontitis crónica, así como el posible uso de terapias dietéticas basadas en estos para el tratamiento de dicha enfermedad.Métodos. Se utilizó la base de datos de la National Library of Medicine, Washington, DC (MEDLINE: PubMed) y todos los estudios en animales y humanos tratando el tema de interés en escritos Inglés disponibles online desde la creación de la base de datos hasta Mayo de 2015 fueron recopilados.Resultados. Los antioxidantes analizados a este respecto incluyen a la vitamina C, la vitamina A, algunos carotenoides y polifenoles, y el coenzima Q; así como los minerales, hierro, cobre y zinc que forman parte de enzimas antioxidantes. Aun así hay una escasez generalizada de estudios con pocos estudios en humanos, la mayoría de tipo observacional. Entre los diferentes antioxidantes, la vitamina E y los polifenoles parecen ser los que más evidencias a favor de su efecto beneficioso suman, pero en general los estudios son insuficientes para descartar o establecer qué antioxidantes son útiles y cuáles no.Conclusiones. En general, los datos presentados indicarían que los antioxidantes de la dieta resultan beneficiosos para la salud periodontal, al menos bajo ciertas circunstancias. Sin embargo se necesitan más estudios para establecer la relación entre la periodontitis crónica y cada antioxidante concreto así como para diseñar intervenciones dietéticas útiles en la gestión de esta enfermedad. Methods. The database of the National Library of Medicine, Washington, DC (MEDLINE PubMed) was used and all the studies in animals and humans are on the subject of interest in English writing online available from inception of the database until May 2015 were collected.Results. Antioxidants analyzed in this regard include vitamin C, vitamin A, carotenoids and some polyphenols, and coenzyme Q; as well as minerals iron, copper and zinc that are constituents of antioxidant enzymes. Still, there is a paucity of studies with few human studies, mostly observational. Among the various antioxidants, vitamin E and polyphenols seem to have more evidence for its beneficial effect, but Artículo de revisión Review Article Correspondencia CorrespondenceJosé Luis Quiles Morales, Centro de Investigación Biomédica (CIBM), Lab. 250. Universidad de Granada, Avda. del Conocimiento s.n., 18100 Armilla, Granada, España. E-Mail: jlquiles@ugr. es; Tel.: +34958241000 (ext. 20316). Financiación FundingsTrabajo realizado sin financiación. Conflicto de interés Competing interest No hay conflicto de intereses Agradecimientos AcknowledgementsLos autores agradecen a la Junta de Andalucía y a la Universidad de Granada por el continuo soporte al grupo de investigación. Alfonso Varela López es contratado FPU del Ministe...

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Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling

Cited by 43 publications

References 41 publications

Influence of lymphatic endothelial cells on proliferation and invasiveness of esophageal carcinoma cells in vitro and lymphangiogenesis in vivo

Influence of lymphatic endothelial cells on proliferation and invasiveness of esophageal carcinoma cells in vitro and lymphangiogenesis in vivo

Exploration of Mango Fruits (Mangifera indica) as α-Glucosidase Inhibitors

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

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