Effect of Mannan-rich fraction supplementation on commercial broiler intestinum tenue and cecum microbiota

Leigh, Robert J.; Corrigan, A.; Murphy, Richard A.; Walsh, Fiona

doi:10.1186/s42523-022-00208-6

Cited by 5 publications

(8 citation statements)

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“…While this trend may seem counterintuitive, all these species (with the exception of Megamonas funiformis ) are relatively rare (η% < 1%). Interestingly, Proteobacteria were not significantly lower with MRF-supplementation (as is often observed in broiler studies [ 18 , 22 , 53 , 98 , 100 ]. Proteobacteria in both control and MRF-supplemented birds were rare (η% < 1%) which may indicate population stability at this timepoint in the layer lifecycle.…”

Section: Discussionmentioning

confidence: 65%

“…Chickens lack the capacity to digest fibre ( e.g. arabinoxylan and (1,3;1,4)-β-glucan) and rely on complex cecal microbiota to extract energy and nutrients from these sources [ 9 , 41 , 53 ]. An indicator of increased cecal fibre digestion is an increase in SCFA producer species [ 86 , 94 ].…”

Section: Discussionmentioning

confidence: 99%

“…Microbiota alteration and microbiome augmentation has been particularly successful in promoting flock health in both broilers and laying hens [ 19 , 22 , 53 , 69 ]. As the hen gut microbiome responds well to dietary factors, this provides a manipulation susceptible and cost-effective avenue for more sustainable meat and egg production [ 2 , 13 , 90 ].…”

Section: Introductionmentioning

confidence: 99%

“…increases in Clostridium spp.) yielding decreased performance [ 30 , 53 , 78 ]. As the microbiome, and constituent microbiota, modulate against animal and human pathogens, produce vitamins, aid in energy acquisition, and aid in host immune system maturation, maintenance of an optimal and uniform microbiome is of utmost importance in sustainable agriculture [ 61 , 103 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mannan rich fraction (MRF), derived from the Saccharomyces cerevisiae cell wall, is a prebiotic that has been shown to successfully lower pathogen bioburden by binding type-1 fimbriated bacteria ( e.g ., Escherichia spp. and Salmonella spp.,) via mannose receptors [ 99 ], 2015,[ 62 ], increase microbiome ecosystem diversity, and improve broiler performance in numerous studies without the use of antibiotic growth promoters [ 19 , 20 , 53 , 69 ]. Additionally, parameters such average daily feed intake (ADFI), body weight (BW), egg weight (EW), and egg production (EP) of the hen, are important measures of productivity in the layer industry [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Yeast mannan rich fraction positively influences microbiome uniformity, productivity associated taxa, and lay performance

Leigh,

Corrigan,

Murphy

et al. 2024

anim microbiome

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Background Alternatives to antibiotic as growth promoters in agriculture, such as supplemental prebiotics, are required to maintain healthy and high performing animals without directly contributing to antimicrobial resistance bioburden. While the gut microbiota of broiler hens has been well established and successfully correlated to performance, to our knowledge, a study has yet to be completed on the effect of prebiotic supplementation on correlating the mature laying hen productivity and microbiota. This study focused on establishing the impact of a yeast derived prebiotic, mannan rich fraction (MRF), on the cecal microbiota of late laying hens. This study benefitted from large sample sizes so intra- and intergroup variation effects could be statistically accounted for. Results Taxonomic richness was significantly greater at all taxonomic ranks and taxonomic evenness was significantly lower for all taxonomic ranks in MRF-supplemented birds (P < 0.005). Use of principal coordinate analyses and principal component analyses found significant variation between treatment groups. When assessed for compositional uniformity (an indicator of flock health), microbiota in MRF-supplemented birds was more uniform than control birds at the species level. From a food safety and animal welfare perspective, Campylobacter jejuni was significantly lower in abundance in MRF-supplemented birds. In this study, species associated with high weight gain (an anticorrelator of performance in laying hens) were significantly lower in abundance in laying hens while health-correlated butyrate and propionate producing species were significantly greater in abundance in MRF-supplemented birds. Conclusions The use of prebiotics may be a key factor in controlling the microbiota balance limiting agri-food chain pathogen persistence and in promoting uniformity. In previous studies, increased α- and β-diversity indices were determinants of pathogen mitigation and performance. MRF-supplemented birds in this study established greater α- and β-diversity indices in post-peak laying hens, greater compositional uniformity across samples, a lower pathogenic bioburden and a greater abundance of correlators of performance.

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