Effect of Manual Lymphdrainage Massage on Blood Components and Urinary Neurogormones in Chronic Lymphedema

Kurz, W; Kurz, R; Litmanovitch, Y.I.; Romanoff, H; Pfeifer, Y.; Sulman, F. G.

doi:10.1177/000331978103200204

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…MLD therapy is used to improve lymph flow in the lymphatic system and to discharge metabolites into the circulatory system and then into the excretory system [ 30 , 31 ]. MLD therapy can also stimulate the flow of nutrients transported through the blood to the tissues, as well as improve the metabolism of adipose tissue and the drainage of metabolic products [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Significant Decrease in Glycated Hemoglobin, 2h-Post-Load Glucose and High-Sensitivity C-Reactive Protein Levels in Patients with Abnormal Body Mass Index after Therapy with Manual Lymphatic Drainage

et al. 2022

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The objective of this study was to investigate the effect of manual lymphatic drainage (MLD) on the insulin resistance parameter (HOMA-IR), glycated hemoglobin (HbA1c), C-peptide, insulin, fasting plasma glucose (FPG), 2h-post-loadglucose (2h-PG) and the concentration of high-sensitivity C-reactive protein (hsCRP) in patients with abnormal body mass index. The study involved 30 patients, including patients with normal body weight (as a control group; group I; n = 14), overweight patients (group II; n = 9) and obese patients (group III; n = 7). Each patient underwent 10 sessions of MLD therapy, 3 times a week for 30 min. In addition, we measured body mass index (BMI) and waist-to-hip ratio (WHR) and performed body composition analysis as well as biochemical tests before MLD therapy (stage 0′) and after MLD therapy (stage 1′). A statistically significant correlation was demonstrated between the concentration of C-peptide, BMI, the amount of visceral adipose tissue (r = 0.87, p = 0.003; r = 0.76, p = 0.003, respectively), and the HOMA-IR index, BMI and the amount of visceral adipose tissue (r = 0.86, p = 0.005; r = 0.84, p = 0.042, respectively), before and after MLD therapy. In overweight patients (group II), a statistically significant (p = 0.041) decrease in the hsCRP level by 2.9 mg/L and a significant (p = 0.050) decrease in the 2h-PG level by 12 mg/dL after the MLD therapy was detected. Moreover, in the group of obese patients (group III), a statistically significant (p = 0.013) decrease in HbA1c level by 0.2% after MLD therapy was demonstrated. Our results indicate that MLD may have a positive effect on selected biochemical parameters, with the most favorable changes in overweight patients. Further studies in a larger number of patients are warranted to confirm our findings, to test in-depth their mechanism, and to investigate clinical benefits of this alternative therapy in patients with abnormal body mass index.

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Section: Introductionmentioning

confidence: 99%

Significant Decrease in Glycated Hemoglobin, 2h-Post-Load Glucose and High-Sensitivity C-Reactive Protein Levels in Patients with Abnormal Body Mass Index after Therapy with Manual Lymphatic Drainage

et al. 2022

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“…Kurz et al 21 found changes in excretion of urinary neurohormones, specifically significant increases in histamine and serotonin, immediately following MLD in patients with lymphedema whereas no changes were found in healthy controls post-MLD. 21,22 In a pilot study, Tan et al. 23 reported near-infrared fluorescence imaging visualized lymphatic contractility improvements with an increase in both lymph velocity and propulsive frequencies immediately post-MLD for the involved and contralateral limbs in patients with known lymphedema and in both limbs of healthy controls.…”

Section: Quantitative Changes After Mldmentioning

confidence: 99%

Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema

Donahue

Crescenzi

Scott

et al. 2017

Lymphatic Research and Biology

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Background: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD). Methods and Results: Measurements to identify lymphatic dysfunction in healthy volunteers (n = 29) and patients with BCRL (n = 16) consisted of (1) limb volume, tissue dielectric constant, and bioelectrical impedance (i.e., non-MRI measures); (2) qualitative 3 Tesla diffusion-weighted, T 1 -weighted and T 2 -weighted MRI; and (3) quantitative multi-echo T 2 MRI of the axilla. Measurements were repeated in patients immediately following MLD. Normative control and BCRL T 2 values were quantified and a signed Wilcoxon Rank-Sum test was applied (significance: two-sided p < 0.05). Non-MRI measures yielded significant capacity for discriminating between arms with versus without clinical signs of BCRL, yet yielded no change in response to MLD. Alternatively, a significant increase in deep tissue T 2 on the involved (pre T 2 = 0.0371 -0.003 seconds; post T 2 = 0.0389 -0.003; p = 0.029) and contralateral (pre T 2 = 0.0365 -0.002; post T 2 = 0.0395 -0.002; p < 0.01) arms was observed. Trends for larger T 2 increases on the involved side after MLD in patients with stage 2 BCRL relative to earlier stages 0 and 1 BCRL were observed, consistent with tissue composition changes in later stages of BCRL manifesting as breakdown of fibrotic tissue after MLD in the involved arm. Contrast consistent with relocation of fluid to the contralateral quadrant was observed in all stages. Conclusion: Quantitative deep tissue T 2 MRI values yielded significant changes following MLD treatment, whereas non-MRI measurements did not vary. These findings highlight that internal imaging measures of tissue composition may be useful for evaluating how current and emerging therapies impact tissue function.

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Appendix: Guidelines for Patients and Medical Staff

Wound Healing and Ulcers of the Skin

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Effect of Manual Lymphdrainage Massage on Blood Components and Urinary Neurogormones in Chronic Lymphedema

Cited by 9 publications

References 10 publications

Significant Decrease in Glycated Hemoglobin, 2h-Post-Load Glucose and High-Sensitivity C-Reactive Protein Levels in Patients with Abnormal Body Mass Index after Therapy with Manual Lymphatic Drainage

Significant Decrease in Glycated Hemoglobin, 2h-Post-Load Glucose and High-Sensitivity C-Reactive Protein Levels in Patients with Abnormal Body Mass Index after Therapy with Manual Lymphatic Drainage

Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema

Appendix: Guidelines for Patients and Medical Staff

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