Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells

Abstract

The skin is the largest organ of the human body, composed of a diverse range of cell types, non-cellular components, and an extracellular matrix. With aging, molecules that are part of the extracellular matrix undergo qualitative and quantitative changes and the effects, such as a loss of skin firmness or wrinkles, can be visible. The changes caused by the aging process do not only affect the surface of the skin, but also extend to skin appendages such as hair follicles. In the present study, the ability of marine-derived saccharides, L-fucose and chondroitin sulphate disaccharide, to support skin and hair health and minimize the effects of intrinsic and extrinsic aging was investigated. The potential of the tested samples to prevent adverse changes in the skin and hair through stimulation of natural processes, cellular proliferation, and production of extracellular matrix components collagen, elastin, or glycosaminoglycans was investigated. The tested compounds, L-fucose and chondroitin sulphate disaccharide, supported skin and hair health, especially in terms of anti-aging effects. The obtained results indicate that both ingredients support and promote the proliferation of dermal fibroblasts and dermal papilla cells, provide cells with a supply of sulphated disaccharide GAG building blocks, increase ECM molecule production (collagen and elastin) by HDFa, and support the growth phase of the hair cycle (anagen).

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

“…Marine-derived L-fucose and chondroitin sulfate disaccharide have been shown to support skin and hair health by promoting the proliferation of dermal fibroblasts and dermal papilla cells, increasing ECM molecule production (collagen and elastin), and supporting the anagen phase of the hair cycle (anagen phase) [ 73 ]. Collagen VI is an extracellular matrix molecule that is abundantly expressed in the skin.…”

Gynostemma pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth-Inducing Properties In Vivo and In Vitro via the Wnt/β-Catenin Pathway in Dermal Papilla Cells

“…An immortalized human dermal papilla cell (hDPC) line retaining the characteristics of primary DPCs was used for the current study [32,33]. This cell line expresses alkaline phosphatase, versican, alpha-smooth muscle actin, and biglycan.…”

Research Progress in Skin Aging, Metabolism, and Related Products

“…Eighteen β-Glycyrrhetinic acid derivatives can resist skin aging caused by UVB in doses of 10 and 25 µ M, possess good antioxidant activities [88], resist apoptosis, prevent collagen degradation, and significantly restore UVB-induced damage [89] AYAPE (Ala-Tyr-Ala-Pro-Glu) is a pentapeptide isolated from Isochrysis zhanjiangensis. The biological activity of AYAPE against skin aging was assessed using UVB-induced HaCat cells.…”