Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs

Boscán, Pedro; Monnet, Eric; Mama, Khursheed R.; Twedt, David C.; Congdon, Jonathan; Steffey, Eugene

doi:10.2460/ajvr.72.12.1576

Cited by 87 publications

(82 citation statements)

References 34 publications

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“…Maropitant can provide analgesic effect by blocking the pharmacological action of substance P at the spinal cord and brain [1, 7, 30]. NSAIDs produce analgesic and anti-inflammatory effects by inhibiting the production of prostaglandins [35].…”

Section: Discussionmentioning

confidence: 99%

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Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

Fukui

Ooyama

Tamura

et al. 2017

The Journal of Veterinary Medical Science

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Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period. On each occasion, maropitant (1 mg/kg) alone, carprofen (4 mg/kg) alone, a combination of maropitant (1 mg/kg) and carprofen (4 mg/kg), or saline (0.1 ml/kg) was subcutaneously administered at 1 hr prior to the first electrical stimulation for the sevoflurane MAC-BAR determination. The sevoflurane MAC-BAR was significantly reduced by maropitant alone (2.88 ± 0.73%, P=0.010), carprofen alone (2.96 ± 0.38%, P=0.016) and the combination (2.81 ± 0.51%, P=0.0003), compared with saline (3.37 ± 0.56%). There was no significant difference in the percentage of MAC-BAR reductions between maropitant alone, carprofen alone and the combination. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction. Anesthetic premedication with a combination of maropitant and carprofen may not provide any further sparing effect on anesthetic requirement in dogs.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, maropitant is expected to provide analgesic effects by preventing the substance P from binding with the NK 1 receptors located in the dorsal horn. It is reported that maropitant decreased the anesthetic requirements in dogs [1, 7]. …”

mentioning

confidence: 99%

Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

Fukui

Ooyama

Tamura

et al. 2017

The Journal of Veterinary Medical Science

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“…The true pain-modifying effect of maropitant in dogs remains uncertain despite canine studies revealing an anesthetic-sparing effect and a non-inferior effect to morphine in an ovariohysterectomy model. 85,86 Bisphosphonates Administered by iV infusion, this class of drug exerts antiosteoclast activity and can contribute to pain relief in dogs with bone cancer.…”

Section: Maropitantmentioning

confidence: 99%

2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats

Epstein¹,

Rodan²,

Griffenhagen

et al. 2015

Journal of Feline Medicine and Surgery

204

143

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“…Metoclopramide and maropitant are used as antiemetic (Simpson, 2007). For the latter drug, an analgesic action has been hypothesised due to its antagonism toward the NK1 receptors, implicated in the transmission of the painful stimuli (Boscan et al, 2011b).…”

Section: Gastric Erosions/ulcersmentioning

confidence: 99%

“…An aggressive fluid therapy and an antibiotic, antiemetic and antidiarrheal therapy is recommended, but no analgesic drugs are usually included in the protocol. However, between antiemetic drugs, maropitant can have some analgesic effect (Boscan et al, 2011b). Opioids are recommended only in case of intussusception, when a surgical approach is needed (Hedlund and Fossum, 2008).…”

Section: Acute Enteritismentioning

confidence: 99%

Medical Abdominal Visceral Pain in Dogs

Catanzaro¹,

Rocca²,

Salvo³

et al. 2015

American Journal of Animal and Veterinary Sciences

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Abdominal visceral pain of medical origin is one of the most frequent reasons for request of medical treatment in humans. Its control is of paramount importance not only for ethical reasons, but also because, if untreated, pain can cause a stress response leading to alterations concerning many organs and apparatuses. Causes of acute or chronic medical visceral pain in men are numerous, with pain originating from various regions of the body. Considering the similarities with regard to the nervous system between humans and other mammals, it is very likely that pathological conditions that cause visceral pain in men are painful in animals as well. Despite this, in veterinary practice medical visceral pain is rarely considered and poorly treated, often for the difficulty in its identification and for a lack of specific guidelines addressing this specific topic. Moreover, no detailed and specific information on this subject are available in the current literature. The present review lists the main pathologies likely responsible of medical abdominal visceral pain in the canine species, trying to summarize, for each considered condition, the available information regarding the pathogenesis and the management of pain.

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Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs

Abstract: Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs. Results suggest the potential role for neurokinin 1 receptor antagonists to manage ovarian and visceral pain.

Cited by 87 publications

References 34 publications

Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats

Medical Abdominal Visceral Pain in Dogs

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