Effect of maternal age on the ovarian reserve markers, and pregnancy outcome in a sample of Kurdish women in Erbil city

Hussein, Manar J.; Alalaf, Shahla K.; Al-Tawil, Namir G.

doi:10.15218/zjms.2018.002

Cited by 4 publications

(3 citation statements)

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“…Our study showed that age is associated with number of follicles restored. Moreover, the study results showed that moderate negative correlation exists between age and ovarian reserve a similar finding in a study conducted by Hessein in 2015 24. Jehan et al also concluded that sub-fertile women the age greater than or equal to 35 years had a reduced potential of fertility 25…”

Section: Discussionsupporting

confidence: 78%

Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

et al. 2019

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Objective: To determine the ovarian reserve parameters in patients presenting for IVF and intracytoplasmic sperm injection (ICSI) treatment and its association with the number of follicles retrieved and number of oocyte retrieved and fertilized. Methods: A retrospective cross sectional study was conducted at Australian Concept Infertility Medical Centre from January 2017 to August 2017. Around 120 couples presenting to infertility clinics selected for IVF and ICSI with Females (25-45) had their FSH, AMH and AFC done. After ovulation induction, its response was determined by number of follicles retrieved, quality of oocytes retrieved or fertilized and inseminated. SPSS version 20 was used for the purpose of data analysis. Results: The median age of the patients was 34 (29-38) years. A moderate negative correlation of age and FSH levels was observed with quality of oocytes, Number of oocyte inseminated, number of oocyte fertilized and number of follicle restored. However, a positive correlation of AMH and AFC levels were found with quality of oocytes, Number of oocyte inseminated, number of oocyte fertilized and number of follicle restored. The correlation of AMH levels with number of oocyte inseminated (rho 0.729, p-value <0.001), number of oocyte fertilized (rho 0.721, <0.001) and number of follicle restored (rho 0.723, p-value <0.001) were found strongly correlated. Conclusion: Our study concluded that AMH and AFC have a strong correlation with number of follicles restored and number of oocytes retrieved whereas FSH and age has a weak correlation with the number of follicles restored and number of oocytes retrieved. doi: https://doi.org/10.12669/pjms.35.4.753 How to cite this:Siddiqui QA, Anjum S, Zahra F, Yousuf SM. Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.753 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 78%

Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

et al. 2019

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“…Montazerifar and his team found that there was a significant differencein the age of abnormal BMD and normal BMD subjects [29]. Oldness is a mainfactor that influences the OR and produces aging of the ovary; age reduces fertility level [3]. Bone mineral density (BMD) decreases with age, especially in women after menopause because of changes in sex hormone levels [30].…”

Section: Discussionmentioning

confidence: 99%

“…The ovary is a dynamic organ that has most dramatic changes in structure and function of human tissue [1]. The biological and chronological age of the ovary is not constantlycorresponding to each other, so it's vitally important to assessfemale reproduction potential [2,3].Ovarian reserve (OR) is estimation of the ovarian follicles pool size and the oocyte quality, decreaseof ovarian reserve with aging, leading to a decline of the reproductive function of women [4,5]. The commonly used biomarkers to assess OR is measurement of Follicular stimulating hormone (FSH), Estradiol hormone (E2) on day 3 of the cycle, Anti-mullarian hormone (AMH) and Inhibin B are other biomarkers of OR, in addition to Antral Follicle count (AFC) [6,7].…”

Section: Introductionmentioning

confidence: 99%

Association of Anti-Mullerian Hormone and 25-Hydroxyvitamin D in women with low bone mineral density in Babylon, Iraq

Saffar¹,

Taee²

2020

ATMPH

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Background: Decrease Anti-mullerian hormone and vitamin D was linked to increased risks of osteopenia and osteoporosis. Aim of the study: To find any association of Anti-Mullerian hormone and 25-hydroxyvitamin D serum levelswith bone minerals density test results in women. Material and Methods: The study was design as a cross-sectional; it includes one hundred forty five females, their age range from 23-68 years. These females attended Rheumatology department of Merjan Medical City in Babylon /Iraq through the period from September 2017 till March 2018.Hormonal profile (anti-mullarian hormone, and vitamin D) were assessed; and minerals density of the bone was measured by dualenergy x-ray absorptiometry for all participants. Results:The incidenceof osteoporosis and osteopenia in our studied population was(31, 72%, 23.45%) respectively and (44.83%) were with normal resultof bone mineral density study. Significant positivecorrelation (p<0.05) was found between Anti-Mullerian Hormone and Vitamin D serum concentrations with bone minerals densitystudy results. Conclusions:Vitamin D serum levels significantly correlates with Anti-mullerian serum levels in patients withabnormal bone mineral density.

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Iraqi experience in the assessment of anti-Müllerian hormone utilization in clinical practice: An overview

Al-Taee,

Al-Sallami

2023

MJBL

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Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, first recognized due to its action in male sex development. In women, it is synthesized by granulosa cells, pre-antral, and antral follicles; its main function in the ovary appears to be the inhibition of the early steps of folliculogenesis. Measurement of serum AMH made the assessment of ovarian reserve possible for more than 30 years. Its use has been expanded for many clinical implications, including assisted reproductive techniques, menopause, reproductive dysfunctions, the degree of ovarian damage/toxicity, and others. Numerous studies executed in this field concluded that AMH declines with aging; it has a positive correlation with oocyte yield in assisted reproduction; it is upregulated in polycystic ovarian syndrome and decreases in ovarian surgery and cancer therapy. This review aims to highlight the Iraqi experience in the implication of AMH assessment in clinical practice. We reviewed the PubMed database regarding the most recent literature in the assessment of AMH in Iraqi Clinical Practice; studies in polycystic ovarian syndrome (PCOS) patients were excluded. The review results show the importance of AMH assessment in many clinical fields especially for the evaluation of ovarian reserve of an infertile woman either to begin treatment strategists or follow-up patients and oncofertility counseling; yet studies must be encouraged in Iraq about it.

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Effect of maternal age on the ovarian reserve markers, and pregnancy outcome in a sample of Kurdish women in Erbil city

Abstract: Effect of maternal age on the ovarian reserve …….

Cited by 4 publications

References 21 publications

Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

Association of Anti-Mullerian Hormone and 25-Hydroxyvitamin D in women with low bone mineral density in Babylon, Iraq

Iraqi experience in the assessment of anti-Müllerian hormone utilization in clinical practice: An overview

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