Effect of maternal exposure to ozone on reproductive outcome and immune, inflammatory, and allergic responses in the offspring

Sharkhuu, Tuya; Doerfler, Donald L.; Copeland, Carey B.; Luebke, Robert W.; Gilmour, M. Ian

doi:10.3109/1547691x.2011.568978

Cited by 16 publications

(11 citation statements)

References 53 publications

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“…In fact, it has been reported that in utero exposure to cigarette smoke can have negative effects on the health of the child (Tsai et al 2010). Sharkhuu et al (2011) demonstrated that maternal exposure to O 3 produces decreases in immune function and indicators of allergic lung disease in the offspring. Maternal exposure to ZEN can induce adverse effects on the reproductive system of the offspring (Diekman & Long 1989;Schoevers et al 2012).…”

Section: Discussionmentioning

confidence: 98%

Alleviation of zearalenone toxicity by modified halloysite nanotubes in the immune response of swine

Yin

Meng

Zhang

et al. 2014

Food Additives & Contaminants: Part A

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Zearalenone (ZEN) has caused significant economic effects on swine production in China. There is growing concern that exposure to ZEN during pregnancy affects the health of the offspring due to changes in the development of the immune system. To assess the risks associated with maternal ZEN exposure, several immunological parameters were assessed in pregnant sows and their offspring. The main aim of the study was to determine if modified hallosite nanotubes (MHNTs) can be used to protect pigs against the adverse effects of ZEN. Eighteen pregnant sows (second parity Yorkshire sows) were randomly divided into three treatment groups: (1) basal diet (control group); (2) contaminated grain (instead of 50% mouldy corn); and (3) contaminated grain (instead of 50% mouldy corn) + 1% MHNTs. The pregnant sows were fed the different treated diets from days 35 to 70 of gestation. Dietary ZEN exposure decreased the organ coefficient and the mRNA expression levels of IFN-γ, TNF-α, and IL-10, and increased ZEN residues and IL-4 mRNA expression in the spleen of pregnant sows and neonatal piglets. Decreases in the serum IgA and IgG levels were observed in the pregnant sows. Maternal ZEN exposure decreased the organ coefficient and the mRNA expression levels of IFN-γ and IL-10, and increased IL-4 mRNA expression in the spleen of weaning piglets. Exposure to ZEN during pregnancy decreased the level of serum IgG in the weaning piglets. Maternal exposure to ZEN induced histopathological damage and oxidative stress in the spleens of pregnant sows and their piglets. The addition of MHNTs to ZEN-contaminated diets can mitigate the negative effects induced by ZEN in the swine.

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Section: Discussionmentioning

confidence: 98%

Alleviation of zearalenone toxicity by modified halloysite nanotubes in the immune response of swine

Yin

Meng

Zhang

et al. 2014

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that prenatal exposures to air pollution in mice can impair fetal lung growth and increase both airway hyper-responsiveness and infiltration of inflammatory cells [46,47]. Another mouse study showed that exposure during pregnancy to O 3 affected both lung function and reproductive outcomes in the offspring [48]. Increased O 3 exposure was associated with decreases in the number of viable pregnancies and the body weight in the surviving offspring [48].…”

Section: Discussionmentioning

confidence: 99%

Assessing the impact of race, social factors and air pollution on birth outcomes: a population-based study

et al. 2014

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BackgroundBoth air pollution exposure and socioeconomic status (SES) are important indicators of children’s health. Using highly resolved modeled predictive surfaces, we examine the joint effects of air pollution exposure and measures of SES in a population level analysis of pregnancy outcomes in North Carolina (NC).MethodsDaily measurements of particulate matter <2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3) were calculated through a spatial hierarchical Bayesian model which produces census-tract level point predictions. Using multilevel models and NC birth data from 2002–2006, we examine the association between pregnancy averaged PM2.5 and O3, individual and area-based SES indicators, and birth outcomes.ResultsMaternal race and education, and neighborhood household income were associated with adverse birth outcomes. Predicted concentrations of PM2.5 and O3 were also associated with an additional effect on reductions in birth weight and increased risks of being born low birth weight and small for gestational age.ConclusionsThis paper builds on and complements previous work on the relationship between pregnancy outcomes and air pollution exposure by using 1) highly resolved air pollution exposure data; 2) a five-year population level sample of pregnancies; and 3) including personal and areal level measures of social determinants of pregnancy outcomes. Results show a stable and negative association between air pollution exposure and adverse birth outcomes. Additionally, the more socially disadvantaged populations are at a greater risk; controlling for both SES and environmental stressors provides a better understanding of the contributing factors to poor children’s health outcomes.

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“…BPA has been shown to impact various physiological functions in animal models [2], including the immune system [3] that protects the organism from infections. According to the World Health Organization (WHO), infectious diseases are the third leading cause of death worldwide (http://who.int/mediacentre/factsheets/fs310/en/), and recent reports highlighted perinatal exposure to environmental EDCs as a cause of impaired host response capacity to infections [4],[5],[6],[7],[8],[9],[10],[11]. As BPA can be detected in human umbilical blood cord, amniotic fluid or maternal milk [12], a special attention has been paid to exposure during the perinatal period, during which most functions of the organism are immature, and considered as particularly vulnerable to adverse environmental factors, including EDCs.…”

Section: Introductionmentioning

confidence: 99%

Perinatal Exposure to a Low Dose of Bisphenol A Impaired Systemic Cellular Immune Response and Predisposes Young Rats to Intestinal Parasitic Infection

et al. 2014

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Perinatal exposure to the food contaminant bisphenol A (BPA) in rats induces long lasting adverse effects on intestinal immune homeostasis. This study was aimed at examining the immune response to dietary antigens and the clearance of parasites in young rats at the end of perinatal exposure to a low dose of BPA. Female rats were fed with BPA [5 µg/kg of body weight/day] or vehicle from gestational day 15 to pup weaning. Juvenile female offspring (day (D)25) were used to analyze immune cell populations, humoral and cellular responses after oral tolerance or immunization protocol to ovalbumin (OVA), and susceptibility to infection by the intestinal nematode Nippostrongylus brasiliensis (N. brasiliensis). Anti-OVA IgG titers following either oral tolerance or immunization were not affected after BPA perinatal exposure, while a sharp decrease in OVA-induced IFNγ secretion occurred in spleen and mesenteric lymph nodes (MLN) of OVA-immunized rats. These results are consistent with a decreased number of helper T cells, regulatory T cells and dendritic cells in spleen and MLN of BPA-exposed rats. The lack of cellular response to antigens questioned the ability of BPA-exposed rats to clear intestinal infections. A 1.5-fold increase in N. brasiliensis living larvae was observed in the intestine of BPA-exposed rats compared to controls due to an inappropriate Th1/Th2 cytokine production in infected jejunal tissues. These results show that perinatal BPA exposure impairs cellular response to food antigens, and increases susceptibility to intestinal parasitic infection in the juveniles. This emphasized the maturing immune system during perinatal period highly sensitive to low dose exposure to BPA, altering innate and adaptative immune response capacities in early life.

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Effect of maternal exposure to ozone on reproductive outcome and immune, inflammatory, and allergic responses in the offspring

Cited by 16 publications

References 53 publications

Alleviation of zearalenone toxicity by modified halloysite nanotubes in the immune response of swine

Alleviation of zearalenone toxicity by modified halloysite nanotubes in the immune response of swine

Assessing the impact of race, social factors and air pollution on birth outcomes: a population-based study

Perinatal Exposure to a Low Dose of Bisphenol A Impaired Systemic Cellular Immune Response and Predisposes Young Rats to Intestinal Parasitic Infection

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