Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse

Shimizu, Ryuhei; Umezawa, Masakazu; Okamoto, Saki; Onoda, Atsuto; Uchiyama, Mariko; Tachibana, Kunihide; Watanabe, Shiho; Ogawa, Seishi; Ryo, Akihide; Takeda, Ken

doi:10.2131/jts.39.571

Cited by 22 publications

(20 citation statements)

References 54 publications

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“…Carbon-based Nanomaterials and Metal NPs. El-Sayed et al reported the adverse effects on the immune system of offspring after gestational exposure to CB NPs [32,111]. After pregnant ICR mice were instilled intranasally with CB NPs (14 nm, 95 µg/kg) on GD9 and GD15, CB NPs triggered alterations in thymocyte and splenocyte phenotypes, and upregulated Traf6 gene expression in the thymus.…”

Section: Immunotoxicitymentioning

confidence: 99%

Fetotoxicity of Nanoparticles: Causes and Mechanisms

et al. 2021

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The application of nanoparticles in consumer products and nanomedicines has increased dramatically in the last decade. Concerns for the nano-safety of susceptible populations are growing. Due to the small size, nanoparticles have the potential to cross the placental barrier and cause toxicity in the fetus. This review aims to identify factors associated with nanoparticle-induced fetotoxicity and the mechanisms involved, providing a better understanding of nanotoxicity at the maternal–fetal interface. The contribution of the physicochemical properties of nanoparticles (NPs), maternal physiological, and pathological conditions to the fetotoxicity is highlighted. The underlying molecular mechanisms, including oxidative stress, DNA damage, apoptosis, and autophagy are summarized. Finally, perspectives and challenges related to nanoparticle-induced fetotoxicity are also discussed.

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Section: Immunotoxicitymentioning

confidence: 99%

Fetotoxicity of Nanoparticles: Causes and Mechanisms

et al. 2021

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“…In addition, CB-NPs could also significantly upregulate the expression level of ll15 in the newborn male offspring as well as Ccr7 and Ccl19 in the female offspring. These results indicated that exposure of pregnant mice to CB-NPs may suppress the development of the immune system in the offspring [ 86 ].…”

Section: Toxicity Of Nps To the Placental Barrier And Embryonic Develmentioning

confidence: 99%

Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development

Hou

Zhu

2017

Oncotarget

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Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman’s body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida. NPs disrupt sex hormone levels through the hypothalamic–pituitary-gonadal axis or by direct stimulation of secretory cells, such as granule cells, follicle cells, thecal cells and the corpus luteum. Some NPs can cross the placenta into the fetus by passive diffusion or endocytosis, which can trigger fetal inflammation, apoptosis, genotoxicity, cytotoxicity, low weight, reproductive deficiency, nervous damage, and immunodeficiency, among others. The toxicity of these NPs depend on their size, dosage, shape, charge, material and surface-coating. We summarize new findings on the toxic effect of various NPs on the ovary and on oogenesis and embryonic development. Meanwhile, we highlight the problems that need to be studied in the future. This manuscript will also provide valuable guidelines for protecting the female reproductive system from the toxicity of NPs and provide a certain reference value for NP application in the area of ovarian diseases.

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“…Increases in thymocyte and lymphocyte counts were seen in male offspring. Another study using a similar exposure regimen showed that prenatal intranasal instillations of carbon black on GD 5 and 9 induced immunosuppression in newborn mice, which was characterized by the depletion of splenic cells in newborn mice (Shimizu et al 2014). El-Sayed et al (2015) has noted the apparent contrast in the results obtained by Shimizu et al (2014).…”

Section: Developmental Effectsmentioning

confidence: 99%

Evaluating the evidence on genotoxicity and reproductive toxicity of carbon black: a critical review

Chaudhuri

Fruijtier-Pölloth²,

Ngiewih

et al. 2017

Critical Reviews in Toxicology

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Carbon black is produced industrially by the partial combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions. It is considered a poorly soluble, low toxicity (PSLT) particle. Recently, results from a number of published studies have suggested that carbon black may be directly genotoxic, and that it may also cause reproductive toxicity. Here, we review the evidence from these studies to determine whether carbon black is likely to act as a primary genotoxicant or reproductive toxicant in humans. For the genotoxicity endpoint, the available evidence clearly shows that carbon black does not directly interact with DNA. However, the study results are consistent with the mechanism that, at high enough concentrations, carbon black causes inflammation and oxidative stress in the lung leading to mutations, which is a secondary genotoxic mechanism. For the reproductive toxicity endpoint for carbon black, to date, there are various lung instillation studies and one short-term inhalation study that evaluated a selected number of reproduction endpoints (e.g. gestational and litter parameters) as well as other general endpoints (e.g. gene expression, neurofunction, DNA damage); usually at one time point or using a single dose. It is possible that some of the adverse effects observed in these studies may be the result of non-specific inflammatory effects caused by high exposure doses. An oral gavage study reported no adverse reproductive or developmental effects at the highest dose tested. The overall weight of evidence indicates that carbon black should not be considered a direct genotoxicant or reproductive toxicant.

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Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse

Cited by 22 publications

References 54 publications

Fetotoxicity of Nanoparticles: Causes and Mechanisms

Fetotoxicity of Nanoparticles: Causes and Mechanisms

Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development

Evaluating the evidence on genotoxicity and reproductive toxicity of carbon black: a critical review

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