Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria

Iloghalu, Emeka Ifeanyi; Dim, Cyril Chukwudi; Ugwu, Emmanuel Onyebuchi; Onwuka, Chidinma Ifechi; Ozumba, Benjamin C.

doi:10.7860/jcdr/2019/42918.13361

Cited by 2 publications

(3 citation statements)

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“…Thus, residual confounding cannot be excluded. For example, we could not assess the effect of maternal viral loads and CD4 cell counts due to limited reporting and lack of adjustment for these confounders in most of the studies include d. 17,21,[30][31][32]34,37,43,44,[46][47][48][49][50][51][52][53][54] Still, for some of the outcomes studied, such as PTB, the risk was significantly elevated in the majority of the studies with narrow CIs. Third, some of the measured outcomes, such as preeclampsia, 17,21,31,33,36,37,39 were reported by only a few studies (seven).…”

Section: Discussionmentioning

confidence: 99%

Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis

Shinar

Agrawal

Ryu

et al. 2021

Acta Obstet Gynecol Scand

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Introduction Antiretroviral therapy‐naïve pregnant women living with HIV are at an increased risk for adverse pregnancy outcomes. It remains controversial whether this risk persists with antiretroviral therapy. We conducted a systematic review and meta‐analysis to evaluate whether pregnant women living with HIV and receiving antiretroviral therapy antenatally, are at an increased risk of adverse outcomes compared with HIV‐negative controls. Material and methods We searched MEDLINE, Embase, International Pharmaceutical Abstracts, EBM Reviews, PubMed (non‐MEDLINE records), EBSCO CINAHL Complete, Clarivate Web of Science, African Index Medicus, LILACS and Google Scholar for all observational studies comparing pregnant women living with HIV on antiretroviral therapy with HIV‐negative controls from 1 January 1994 to 10 August 2021 with no language or geographic restrictions. Perinatal outcomes included preterm birth (PTB), low birthweight, small‐for‐gestational age and preeclampsia. Using a random‐effects model we pooled raw data to generate odds ratio (OR) with 95% confidence intervals (CI) for each outcome. Sub‐analyses for high and low resource countries and time of antiretroviral therapy initiation were performed. This systematic review and meta‐analysis is registered with PROSPERO, number CRD42020182722. Results Of the 7900 citations identified, 27 were eligible for analysis (12 636 pregnant women living with HIV on antiretroviral therapy and 7 812 115 HIV‐negative controls). ORs (95% CI) of PTB (1.88 [1.63–2.17]), small‐for‐gestational age (1.60 [1.18–2.17]) and low birthweight (2.15 [1.58–2.92]) were significantly higher in pregnant women living with HIV than in HIV‐negative women, while the risk of preeclampsia (0.86 [0.57–1.30]) was comparable. The risk of PTB and low birthweight was higher in both high resource and low resource countries, while the risk of small‐for‐gestational age was higher only in the former. Preconceptional antiretroviral therapy was associated with a higher risk of PTB compared with antenatal initiation. Conclusions Pregnant women living with HIV on antiretroviral therapy have an increased risk of PTB, low birthweight and small‐for‐gestational age in high resource countries, as well as PTB and low birthweight in low income countries compared with HIV‐negative controls.

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Section: Discussionmentioning

confidence: 99%

Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis

Shinar

Agrawal

Ryu

et al. 2021

Acta Obstet Gynecol Scand

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“…Os achados relacionados às variáveis maternas, como idade, escolaridade e etnia, coadunam-se com o perfil encontrado na literatura, ratificando a importância da valorização do seguimento do pré-natal e do tratamento da criança, os quais devem ser priorizados pelas políticas públicas a fim de divulgar informações pertinentes que evitem o abandono dos serviços de saúde, com vistas à redução da transmissão vertical, além da conscientização acerca da importância da adesão e permanência no acompanhamento de saúde infantil, para evitar desfechos desfavoráveis (10)(11) .…”

Section: Discussionunclassified

“…Crianças de baixo risco consultam somente na atenção primária à saúde; crianças de risco intermediário e alto risco são atendidos em serviços ambulatoriais secundários, os quais promovem consultas com pediatras, especialistas, e equipes multiprofissionais, além de disponibilizar todos os exames prescritos (9) . Considerou-se como único critério de inclusão o prontuário de bebês de mães diagnosticadas com sífilis, toxoplasmose ou HIV durante a gestação, conforme recomendado pela Linha Guia da Rede Mãe Paranaense (10) . Não houve adoção de critério de exclusão.…”

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Abandonment of health monitoring of babies of mothers with vertical transmission grievance

Shibukawa

Merino

Lanjoni³

et al. 2021

Rev Rene

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Objective: to analyze the abandonment of the health monitoring of babies of mothers with vertical transmission grievance. Methods: a retrospective documental study. The data came from children’s records stratified as high risk by the Paranaense Mother Network Program, due to being daughters of women diagnosed with syphilis, toxoplasmosis or Human Immunodeficiency Virus in the gestational period, attended in a reference center of maternal-infant care. For the analysis of factors associated with abandonment of treatment, univariate analysis and Fisher’s Exact Test with sociodemographic variables were performed. All ethical precepts were observed. Results: a total of 136 medical records were analyzed. The cases with the highest abandonment rate were the children of women with toxoplasmosis and gestational syphilis, presenting rates of 48.4% and 45.7%, respectively. Conclusion: the abandonment of baby health monitoring is recurrent. The reasons for frequent abandonment were: lack of active search, lack of transportation and unforeseen family events.

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Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria

Cited by 2 publications

References 0 publications

Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis

Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis

Abandonment of health monitoring of babies of mothers with vertical transmission grievance

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