Effect of Maternal Preeclampsia on the Weight of the Placenta

Kishwara, Segupta; Nurunnabi, Abu Sadat Mohammad; Begum, Momotaz; Rayhan, Khandaker Abu; Ara, Shamim

doi:10.3329/bja.v8i2.7019

Cited by 4 publications

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References 8 publications

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“…This study also reveals that mean number of areas of syncytial knot formation (26.76), cytotrophoblastic cell proliferation (21.52), area of fibrinoid necrosis(10.68), and hyalinised villi (9.46) were increased in case of pre-eclamptic women, compared to normal pregnancy which were (9.60), (7.16) (2.24) and (2.32) respectively 33. M. Akhlag,.…”

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confidence: 55%

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Khan¹,

Nahid²,

Chowdhury³

et al. 2023

J Dhaka Med Coll

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Pre-eclampsia is a disorder of 2nd half of pregnancy, which is characterized by a combination of hypertension, proteinuria and edema, secondary to decreased placental perfusion. Clinical studies suggest that there are histopathological changes in the placenta of pre-eclamptic women, compared to normotensive pregnant women. In developing countries, pre-eclampsia causes an estimated 50,000 maternal deaths per year. Only a small number of studies have however, been conducted in Bangladesh. Objective: To compare the histopathology of placenta in selected pre-eclamptic and normotensive pregnant women. Methods: 220 pregnant women were selected with inclusion and exclusion criteria from 3 different medical colleges and divided into 2 groups – A study group, consisting of 110 pre-eclamptic women and a control group consisting of 110 normotensive pregnant women. Dietary information was collected by 7 days food frequency questionnaire and food score was determined. Anthropometric and biochemical tests were performed. To evaluate the histopathology of placenta, tissue samples were collected from the placenta after delivery, and were prepared for histopathological studies, by haemotoxylin and eosin stain method. The mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis, and the mean number of areas of hyalinised villi of pre-eclamptic and normal pregnant women were evaluated. Results: The mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis, and the mean number of areas of hyalinised villi were found to be significantly higher in the study group, compared to the control group. Conclusion: Therefore, mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis is increased in the placenta of pre-eclamptic women, compared to normotensive pregnant women. J Dhaka Med Coll. 2021; 30(2) : 189-195

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confidence: 55%

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Khan¹,

Nahid²,

Chowdhury³

et al. 2023

J Dhaka Med Coll

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“…A study was conducted by Shah et al 23 ., 1985; and others (Cibil LA 24 , Teasdale 25 , Barua R 26 ., and Begum 27 ), they also observed reduced placental weight (390.82 gm) in Pre-eclamptic women in compared to normal pregnant women (496.56 gm). A study was conducted by Segupta Kishwara, Abu Sadat, Shamim Ara 28 and others, Department of Anatomy, Dhaka Medical College, 2010. They observed lower placental weight in pre-eclampsia compare to normal pregnancy .Many foreign studies have shown the effect of Hypertensive disorders of pregnancy on the placental weight and the overall status of the mother and the baby, they reported the moderate to severe reduction of placental weight in pre-eclampsia and eclampsia 29 .…”

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confidence: 99%

Morphological study of placenta in selected normotensive and pre-eclamptic women in Bangladesh

et al. 2021

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Pre – Eclampsia is a disorder of 2nd half of pregnancy, which is characterized by a combination of hypertension, proteinuria and edema, secondary to decreased placental perfusion. Clinical studies suggest that there are morphological changes in the placenta of pre-eclamptic women, compared to normotensive pregnant women. In developing countries, pre-eclampsia causes an estimated 50,000 maternal deaths per year. Only a small number of studies have however, been conducted in Bangladesh. Objective: To compare the morphology of placenta in selected pre-eclamptic and normotensive pregnant women. Methods: 220 pregnant women were selected with inclusion and exclusion criteria from 3 different medical colleges and divided into 2 groups – A study group, consisting of 110 pre-eclamptic women and a control group consisting of 110 normotensive pregnant women. Dietary information was collected by 7 days food frequency questionnaire and food score was determined. Anthropometric and biochemical tests were performed. To measure the weight of the placentas, the decidual part of the placentas were removed. The umbilical cords were then cut, nearest to the placenta, to drain the blood from the placental vessels, and the weight was recorded upto nearest gram with weighing machine. The diameters of placentas were measured by taking the average of two maximum diameters of placentas with measuring tape (cm).The cotyledons were counted from maternal side after removal of deciduas basalis. Number of placental infarcts were counted from fetal side. Results: The mean weights, diameters, number of cotyledons were found to be significantly lower in the study group, compared to the control group. The number of infarcted areas was significantly higher in the placentas of pre-eclamptic women Conclusion: Therefore, weight, diameter and number of cotyledons are decreased and number of infarcted areas are increased in the placenta of pre-eclamptic women, compared to normotensive pregnant women. J Dhaka Medical College, Vol. 29, No.2, October, 2020, Page 171-177

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