Effect of maternal protein and/or energy deficiency during pregnancy on catecholamines and serotonin in fetal rat brain.

Hisatomi, S; Sasaki, Satoshi; Niyama, Y

doi:10.3177/jnsv.25.243

Cited by 2 publications

(4 citation statements)

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“…As reported previously, the concentrations and total amounts of NE in the forebrain, cerebellum, and brain stem of neonates were 70, 92, and 130pg/mg and 7.73, 2.96, and 7.04ng, respectively (22). Since both the concentration of NE and the tissue mass increased, the total amounts of NE in the At birth the concentrations of DA (pg/mg) in the forebrain, cerebellum, and brain stem are 69, 70, and 49, respectively, and the total amounts (ng) are 7.63, 2.27, and 2.67, respectively (22). Both the concentration and the total amount of DA increased greatly in the forebrain of normal pups during suckling: on day 21 the total amount was 982ng, constituting 96% of that in the whole brain, and representing about 130 times the amount on day 1.…”

Section: Resultssupporting

confidence: 84%

“…Since regional differences are seen in growth retardation of the brain in undernourished rats (6), it seemed to be interesting to examine whether specific neurons are affected by malnutrition. Previously we reported that the catecholamine content of normal fetal brain increased from 21ng on day 18 of gestation to 52ng at birth (22). However, there are many reports that the monoamine content of developing brain increased far more rapidly just after birth than before birth.…”

Section: Discussionmentioning

confidence: 79%

“…In the well-nourished group, the total DNA content increased appreciably in all regions during suckling. The DNA contents of the forebrain, cerebellum, and brain stem on day 21 were, respectively, 2.3, 16, and 3.4 times higher than those at birth (22). Proliferation of cerebellar cells was associated with increases in both cell density (DNA concentration) and tissue mass (cerebellar weight).…”

Section: Resultsmentioning

confidence: 88%

“…The total activities of TH, expressed as pg of dopamine formed for 30 min, in the forebrain, cerebellum, and brain stem of normal neonates were found to be 0.62, 0.43, and 0.39, respectively (22). On day 21 of life, the total activities in the forebrain and brain stem were about 30-fold those at birth, reflecting high NE or DA contents in these regions.…”

Section: Resultsmentioning

confidence: 89%

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Effects of postnatal undernutrition on the catecholamine and serotonin contents of suckling rat brain.

Hisatomi

Niiyama

1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of postnatal undernutrition on the catecholamine and serotonin contents of various parts of the brain of suckling rats was examined. Undernourishment was induced by increasing the litter size to 18 pups from day 1 to 21 after birth. In control pups, the total amounts of norepinephrine and dopamine in the whole brain increased greatly during the suckling period (norepinephrine: 17.7ng at birth, 154ng on day 10, and 420ng on day 21; dopamine: 12.6ng at birth, 269ng on day 10, and 1,022ng on day 21). Similar, but less marked increases in the norepinephrine and dopamine contents of the brain were observed in malnourished pups. The norepinephrine contents of the forebrain, cerebellum, and brain stem of malnourished pups were comparable with those of normal pups on day 10 but the contents of the cerebellum and brain stem were significantly less than those of normal pups on day 21. Postnatal malnutrition also led to a significant decrease in the dopamine content of the forebrain. In contrast, the serotonin content of the brain of undernourished pups was significantly higher than that of controls. The activities of tyrosine hydroxylase in the forebrain and brain stem of control pups at the end of suckling period were significantly higher than those of undernourished pups (forebrain: 18.3pmol in controls and 11.5 pmol in malnourished pups; brain stem: 12.3pmol in controls and 9.8 pmol in malnourished pups). The tyrosine hydroxylase activity (pmol/g) correlated more closely with the norepinephrine content than with the dopamine or norepinephrine plus dopamine content. The tyrosine and phenylalanine contents of the brain were similar in the two groups. It is concluded from these findings that the catecholamine content of the brain is regulated by the enzyme activity rather than the levels of precursor amino acids. Keywords brain catecholamine (CA), serotonin, tyrosine hydroxylase, early postnatal malnutrition, lactation, brain free amino acids 279

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Section: Resultssupporting

confidence: 84%

Section: Discussionmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 89%

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