Effect of maternal renin-angiotensin-aldosterone system activation on social coping strategies and gene expression of oxytocin and vasopressin in the brain of rat offspring in adulthood

Abstract

The intrauterine condition in which the mammalian foetus develops has an important role in prenatal programming. The aim of this study was to determine the extent to which activation of the maternal renin-angiotensin-aldosterone system (RAAS) could influence social behaviour strategies in offspring via changes in social neurotransmitters in the brain. Pregnant female Wistar rats were implanted with osmotic minipumps which continually released angiotensin II for 14 days at concentration of 2 μg/kg/h. The adult offspring (angiotensin and control groups) underwent a social interaction test. The mRNA expression of vasopressin, oxytocin and the oxytocin receptor in selected brain areas was measured by in situ hybridisation. Prenatal exposure to higher levels of angiotensin II resulted in a strong trend toward decreased total social interaction time and significantly decreased time spent in close proximity and frequency of mutual sniffing. The angiotensin group showed no changes in oxytocin mRNA expression in the hypothalamic paraventricular or supraoptic nuclei, but this group had reduced vasopressin mRNA expression in the same areas. We concluded that maternal activation of RAAS (via higher levels of angiotensin II) caused inhibition of some socio-cohesive indicators and decreased vasopressinergic activity of offspring. Taken together, these results suggest a reactive rather than proactive social coping strategy.

Lisinopril reverses behavioural alterations in spontaneously hypertensive rats

“…Experimental cardiovascular pathologies are associated with different neuropsychiatric symptoms, while on the contrary, various mental disorders may support the progression of cardiovascular, neurohumoral or metabolic disorders (Pechanova et al 2006;Bernatova et al 2010;Puzserova et al 2012;Aziriova et al 2016;Olexova et al 2016;Pokusa et al 2016;Senko et al 2017;Repova et al 2018). In a clinical setting, patients with cardiac diseases suffer from post-traumatic stress disorder (Vilchinsky et al 2017), yet mental disorders not only impair their adherence to therapeutic management (Gentil et al 2017); they can also contribute to the progres-sion of cardiovascular diseases (Shields and Slavich 2017).…”